DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Npc1b and Npc1a

DIOPT Version :9

Sequence 1:NP_608417.2 Gene:Npc1b / 33072 FlyBaseID:FBgn0261675 Length:1254 Species:Drosophila melanogaster
Sequence 2:NP_001188769.1 Gene:Npc1a / 34358 FlyBaseID:FBgn0024320 Length:1287 Species:Drosophila melanogaster


Alignment Length:1297 Identity:522/1297 - (40%)
Similarity:771/1297 - (59%) Gaps:109/1297 - (8%)


- Green bases have known domain annotations that are detailed below.


  Fly     3 VIFATIWLIAGAWSQSAEQLGCIWYGQSHMIGAHWVNKGDTNPAR--PLNSPTSE------AIFA 59
            |:|..|        ||::| .|:|||.        .|..|.:.::  |.|....|      .:..
  Fly    21 VLFTLI--------QSSKQ-DCVWYGV--------CNTNDFSHSQNCPYNGTAKEMATDGLELLK 68

  Fly    60 KRCPMLYKEYKGESGEDELSLCCDAAQIETMESGLSQADGVFSRCPTCTRNMALTVCAMTCAKNH 124
            |||..|.     |:.|::  .|||..|:|.:...:..|..:..|||:|..|:...:|..||:...
  Fly    69 KRCGFLL-----ENSENK--FCCDKNQVELLNKNVELAGNILDRCPSCMENLVRHICQFTCSPKQ 126

  Fly   125 TLFL-TAYNDTNDAGVDYVKYIDYRLTDDTVSKIYNSCIGIQHTQTGRPAMDLGCGSYNAKTCNY 188
            ..|: ......|..|.:|:..:|..::.:.::|.|.||..:...|||:.|.||.||:|:|..||.
  Fly   127 AEFMHVVATQKNKKGDEYISSVDLHISTEYINKTYKSCSQVSVPQTGQLAFDLMCGAYSASRCNP 191

  Fly   189 RRWYEFMGDVSGDYVPFQINYKWSEDAEEGSNEIYLDLSPLKCGESYEDSY-ACACIDCEESCPL 252
            .:|:.||||.:..||||||.|...|.....:|...|:::.:.|.::..... ||:|.||:.||| 
  Fly   192 TKWFNFMGDATNPYVPFQITYIQHEPKSNSNNFTPLNVTTVPCNQAVSSKLPACSCSDCDLSCP- 255

  Fly   253 TDAPTGP--DELWKIAGLYGVTFILALIIACALSFFIFWGAFGKTSAPSVC-------------M 302
             ..|..|  .|.:||.||.....|:|.:....:..|:. |:|..|...|:.             |
  Fly   256 -QGPPEPPRPEPFKIVGLDAYFVIMAAVFLVGVLVFLM-GSFLFTQGSSMDDNFQVDGNDVSDEM 318

  Fly   303 PTLFGEFFYHG------------FRIWGTFCAKHPVIVLALCSWAIAGLSFGIRYMTITTDPVEL 355
            |....:.::..            |..|||:.|.:|.:.|...:..:..|.:||.::.||||||:|
  Fly   319 PYSENDSYFEKLGAHTETFLETFFTKWGTYFASNPGLTLIAGASLVVILGYGINFIEITTDPVKL 383

  Fly   356 WAGEESQTRIEKDYFDQHFGPFYRTNQMFVKAVNQTYFTHETSNGVLNFGPAFEYNFLKEVFELQ 420
            ||...|::|:|:::||..|.||||..|:.:||||.....|.||||...|||.|:..||.:|.:||
  Fly   384 WASPNSKSRLEREFFDTKFSPFYRLEQIIIKAVNLPQIVHNTSNGPYTFGPVFDREFLTKVLDLQ 448

  Fly   421 DSIMKLGMADNEGLDKICYAPVLMAGETPTVDRCAIQSVYGYFQHDMDRFENSYVDSNNYTINYL 485
            :.|.::. |:...|..|||||:...|....|.:|.:||::|||..|.:|.:: :.:.|.:.:.||
  Fly   449 EGIKEIN-ANGTQLKDICYAPLSDDGSEIDVSQCVVQSIWGYFGDDRERLDD-HDEDNGFNVTYL 511

  Fly   486 NQLEDCLRVPMMEDCFGTFGGPIEPGIAVGGM--PKVAVGEDPDYMLATGLVLTFLGRNYNDESK 548
            :.|.||:..|.:  |...:|||::|.||:||.  |...:.....:.||..::||||.:|:::::.
  Fly   512 DALYDCISNPYL--CLAPYGGPVDPAIALGGFLPPGDQLTGSTKFELANAIILTFLVKNHHNKTD 574

  Fly   549 LEPNMKWEKLFVDFLRDY----KSDRLDIAYMAERSIQDAIVELSEGEVSTVVISYVVMFVYVAI 609
            ||..:.|||.||:|:.:|    .|..:|||:.:||||:|.:...|:.:|.|:::||::||:|:||
  Fly   575 LENALTWEKKFVEFMTNYTKNNMSQYMDIAFTSERSIEDELNRESQSDVLTILVSYLIMFMYIAI 639

  Fly   610 ALGHIRSCRGFLRESRIMLAIGGIVIVLASVVCSLGFWGYLDVTTTMLAIEVIPFLVLAVGVDNI 674
            :|||::..:....:|:|.|.|||::|||||||.|:|.:||:.:..|::.:|||||||||||||||
  Fly   640 SLGHVKEFKRVFIDSKITLGIGGVIIVLASVVSSVGVFGYIGLPATLIIVEVIPFLVLAVGVDNI 704

  Fly   675 FIMVHTYQRLDHSKFKTTHEAIGEAIGQVGPSILQTAGSEMACFAIGCISDMPAVKTFAMYAAIA 739
            ||:|.|:||......:|..:.:|..:|:||||:|.|:.||..||.:|.:||||||:.||:||.:|
  Fly   705 FILVQTHQRDQRKPNETLEQQVGRILGKVGPSMLLTSLSESFCFFLGGLSDMPAVRAFALYAGVA 769

  Fly   740 ILLDFLLQITAFVALMAIDEKRYLDGRLDMLCCVKSGGKKINDEDGDGVDRPKEV----GLLETL 800
            :::|||||||.||:|..:|.||..:.|:|:.|.:|  |||           |..:    |||...
  Fly   770 LIIDFLLQITCFVSLFTLDTKRREENRMDICCFIK--GKK-----------PDSITSNEGLLYKF 821

  Fly   801 FKNFYSPFLLSKPVKVSVLLIFTVITCLSLMVTPSIEKGLDQEMSMPKNSHVVKYFRYMVDLLAM 865
            |.:.|.|||:.|.|:.||::||....|.|:.:.|.|:.|||||::||::|.|:.||:.:.:.|.:
  Fly   822 FSSVYVPFLMKKIVRASVMVIFFAWLCFSIAIAPRIDIGLDQELAMPQDSFVLHYFQSLNENLNI 886

  Fly   866 GAPVYWVLKPGLNYSEPLQQNLICGGVECNNNSLSVQLYTQAQYPEITSLARPASSWLDDYIDW- 929
            |.|||:|||..|.|:....|||:|.|..||::|:..|:|..:::...|.:|||||||:|||.|| 
  Fly   887 GPPVYFVLKGDLAYTNSSDQNLVCAGQYCNDDSVLTQIYLASRHSNQTYIARPASSWIDDYFDWA 951

  Fly   930 LAISDCCKYNVTTGGFCSSNSKSEDCLPCERGFTENG-LRPDAETFNKYIPYFLFDLPDAECAKA 993
            .|.|.||||...:|.||.....|  ||.|  ..|:|. |||:.:.|.||:|:||.|.||..||||
  Fly   952 AAASSCCKYRKDSGDFCPHQDTS--CLRC--NITKNSLLRPEEKEFVKYLPFFLKDNPDDTCAKA 1012

  Fly   994 GRASYADAVIYTIDDVGMSTVQDSYFMQYSTTSTTSEEFYSQLREVRRISGEINAMFK----ENN 1054
            |.|:|..||.|:.....:: ::.||||.|.|...:|.:::..|...|:||..|..|.:    .|.
  Fly  1013 GHAAYGGAVRYSNSHERLN-IEASYFMAYHTILKSSADYFLALESARKISANITQMLQGRLMSNG 1076

  Fly  1055 V------DAEIFAYCVFYIYYEQYLTIWGDAMFSLGMSLVAIFLVTLLITGLDITSTFIVLFMVI 1113
            |      ..|:|.|.|||::||||||:|.|.:.|:|:|:::||:||.::.|.|:.|..:|:..:.
  Fly  1077 VPMASALTVEVFPYSVFYVFYEQYLTMWSDTLQSMGISVLSIFVVTFVLMGFDVHSALVVVITIT 1141

  Fly  1114 CILINMLGMMWAWSINLNAISLVNLVVCVGIGVEFVAHIVRSFKRAEGTAQ-ERARHSLNVTGSS 1177
            .|::|:.|:|:.|:|:|||:||||||:.|||.|||.:|:|.||..::..:| :||..||:..|||
  Fly  1142 MIVVNLGGLMYYWNISLNAVSLVNLVMAVGISVEFCSHLVHSFATSKSVSQIDRAADSLSKMGSS 1206

  Fly  1178 VLSGITLTKFAGIVVLGFSNSQIFQVFYFRMYLGIVLIGAAHGLILLPVLLSLLGPPQKLAR 1239
            :.|||||||||||:||.|:.||||||||||||||||:||||||||.||||||.:|.|...||
  Fly  1207 IFSGITLTKFAGILVLAFAKSQIFQVFYFRMYLGIVVIGAAHGLIFLPVLLSYIGAPVSNAR 1268

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Npc1bNP_608417.2 2A060601 24..1220 CDD:273337 502/1255 (40%)
NPC1_N 24..270 CDD:293023 81/257 (32%)
nitrilase <265..>331 CDD:299711 19/90 (21%)
Sterol-sensing 623..775 CDD:289145 80/151 (53%)
Npc1aNP_001188769.1 NPC1_N 31..274 CDD:293023 82/260 (32%)
2A060601 33..1261 CDD:273337 512/1267 (40%)
Sterol-sensing 651..804 CDD:289145 80/152 (53%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 185 1.000 Domainoid score I996
eggNOG 1 0.900 - - E1_KOG1933
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 731 1.000 Inparanoid score I114
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D12397at33392
OrthoFinder 1 1.000 - - FOG0001659
OrthoInspector 1 1.000 - - mtm1117
orthoMCL 1 0.900 - - OOG6_101370
Panther 1 1.100 - - P PTHR45727
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X943
109.870

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