Protein Alignment Npc1b and Npc1a

DIOPT Version :10

• Sequence 1: NP_608417.2
• Gene: Npc1b / 33072
• FlyBaseID: FBgn0261675
• Length: 1254
• Species: Drosophila melanogaster
• Sequence 2: NP_609357.2
• Gene: Npc1a / 34358
• FlyBaseID: FBgn0024320
• Length: 1287
• Species: Drosophila melanogaster
• Alignment Length: 1297
• Identity: 522/1297 - (40%)
• Similarity: 771/1297 - (59%)
• Gaps: 109/1297 - (8%)

  Fly     3 VIFATIWLIAGAWSQSAEQLGCIWYGQSHMIGAHWVNKGDTNPAR--PLNSPTSE------AIFA 59
            |:|..|        ||::| .|:|||.        .|..|.:.::  |.|....|      .:..
  Fly    21 VLFTLI--------QSSKQ-DCVWYGV--------CNTNDFSHSQNCPYNGTAKEMATDGLELLK 68

  Fly    60 KRCPMLYKEYKGESGEDELSLCCDAAQIETMESGLSQADGVFSRCPTCTRNMALTVCAMTCAKNH 124
            |||..|.     |:.|::  .|||..|:|.:...:..|..:..|||:|..|:...:|..||:...
  Fly    69 KRCGFLL-----ENSENK--FCCDKNQVELLNKNVELAGNILDRCPSCMENLVRHICQFTCSPKQ 126

  Fly   125 TLFL-TAYNDTNDAGVDYVKYIDYRLTDDTVSKIYNSCIGIQHTQTGRPAMDLGCGSYNAKTCNY 188
            ..|: ......|..|.:|:..:|..::.:.::|.|.||..:...|||:.|.||.||:|:|..||.
  Fly   127 AEFMHVVATQKNKKGDEYISSVDLHISTEYINKTYKSCSQVSVPQTGQLAFDLMCGAYSASRCNP 191

  Fly   189 RRWYEFMGDVSGDYVPFQINYKWSEDAEEGSNEIYLDLSPLKCGESYEDSY-ACACIDCEESCPL 252
            .:|:.||||.:..||||||.|...|.....:|...|:::.:.|.::..... ||:|.||:.|||
  Fly   192 TKWFNFMGDATNPYVPFQITYIQHEPKSNSNNFTPLNVTTVPCNQAVSSKLPACSCSDCDLSCP- 255

  Fly   253 TDAPTGP--DELWKIAGLYGVTFILALIIACALSFFIFWGAFGKTSAPSVC-------------M 302
             ..|..|  .|.:||.||.....|:|.:....:..|:. |:|..|...|:.             |
  Fly   256 -QGPPEPPRPEPFKIVGLDAYFVIMAAVFLVGVLVFLM-GSFLFTQGSSMDDNFQVDGNDVSDEM 318

  Fly   303 PTLFGEFFYHG------------FRIWGTFCAKHPVIVLALCSWAIAGLSFGIRYMTITTDPVEL 355
            |....:.::..            |..|||:.|.:|.:.|...:..:..|.:||.::.||||||:|
  Fly   319 PYSENDSYFEKLGAHTETFLETFFTKWGTYFASNPGLTLIAGASLVVILGYGINFIEITTDPVKL 383

  Fly   356 WAGEESQTRIEKDYFDQHFGPFYRTNQMFVKAVNQTYFTHETSNGVLNFGPAFEYNFLKEVFELQ 420
            ||...|::|:|:::||..|.||||..|:.:||||.....|.||||...|||.|:..||.:|.:||
  Fly   384 WASPNSKSRLEREFFDTKFSPFYRLEQIIIKAVNLPQIVHNTSNGPYTFGPVFDREFLTKVLDLQ 448

  Fly   421 DSIMKLGMADNEGLDKICYAPVLMAGETPTVDRCAIQSVYGYFQHDMDRFENSYVDSNNYTINYL 485
            :.|.::. |:...|..|||||:...|....|.:|.:||::|||..|.:|.:: :.:.|.:.:.||
  Fly   449 EGIKEIN-ANGTQLKDICYAPLSDDGSEIDVSQCVVQSIWGYFGDDRERLDD-HDEDNGFNVTYL 511

  Fly   486 NQLEDCLRVPMMEDCFGTFGGPIEPGIAVGGM--PKVAVGEDPDYMLATGLVLTFLGRNYNDESK 548
            :.|.||:..|.:  |...:|||::|.||:||.  |...:.....:.||..::||||.:|:::::.
  Fly   512 DALYDCISNPYL--CLAPYGGPVDPAIALGGFLPPGDQLTGSTKFELANAIILTFLVKNHHNKTD 574

  Fly   549 LEPNMKWEKLFVDFLRDY----KSDRLDIAYMAERSIQDAIVELSEGEVSTVVISYVVMFVYVAI 609
            ||..:.|||.||:|:.:|    .|..:|||:.:||||:|.:...|:.:|.|:::||::||:|:||
  Fly   575 LENALTWEKKFVEFMTNYTKNNMSQYMDIAFTSERSIEDELNRESQSDVLTILVSYLIMFMYIAI 639

  Fly   610 ALGHIRSCRGFLRESRIMLAIGGIVIVLASVVCSLGFWGYLDVTTTMLAIEVIPFLVLAVGVDNI 674
            :|||::..:....:|:|.|.|||::|||||||.|:|.:||:.:..|::.:|||||||||||||||
  Fly   640 SLGHVKEFKRVFIDSKITLGIGGVIIVLASVVSSVGVFGYIGLPATLIIVEVIPFLVLAVGVDNI 704

  Fly   675 FIMVHTYQRLDHSKFKTTHEAIGEAIGQVGPSILQTAGSEMACFAIGCISDMPAVKTFAMYAAIA 739
            ||:|.|:||......:|..:.:|..:|:||||:|.|:.||..||.:|.:||||||:.||:||.:|
  Fly   705 FILVQTHQRDQRKPNETLEQQVGRILGKVGPSMLLTSLSESFCFFLGGLSDMPAVRAFALYAGVA 769

  Fly   740 ILLDFLLQITAFVALMAIDEKRYLDGRLDMLCCVKSGGKKINDEDGDGVDRPKEV----GLLETL 800
            :::|||||||.||:|..:|.||..:.|:|:.|.:|  |||           |..:    |||...
  Fly   770 LIIDFLLQITCFVSLFTLDTKRREENRMDICCFIK--GKK-----------PDSITSNEGLLYKF 821

  Fly   801 FKNFYSPFLLSKPVKVSVLLIFTVITCLSLMVTPSIEKGLDQEMSMPKNSHVVKYFRYMVDLLAM 865
            |.:.|.|||:.|.|:.||::||....|.|:.:.|.|:.|||||::||::|.|:.||:.:.:.|.:
  Fly   822 FSSVYVPFLMKKIVRASVMVIFFAWLCFSIAIAPRIDIGLDQELAMPQDSFVLHYFQSLNENLNI 886

  Fly   866 GAPVYWVLKPGLNYSEPLQQNLICGGVECNNNSLSVQLYTQAQYPEITSLARPASSWLDDYIDW- 929
            |.|||:|||..|.|:....|||:|.|..||::|:..|:|..:::...|.:|||||||:|||.||
  Fly   887 GPPVYFVLKGDLAYTNSSDQNLVCAGQYCNDDSVLTQIYLASRHSNQTYIARPASSWIDDYFDWA 951

  Fly   930 LAISDCCKYNVTTGGFCSSNSKSEDCLPCERGFTENG-LRPDAETFNKYIPYFLFDLPDAECAKA 993
            .|.|.||||...:|.||.....|  ||.|  ..|:|. |||:.:.|.||:|:||.|.||..||||
  Fly   952 AAASSCCKYRKDSGDFCPHQDTS--CLRC--NITKNSLLRPEEKEFVKYLPFFLKDNPDDTCAKA 1012

  Fly   994 GRASYADAVIYTIDDVGMSTVQDSYFMQYSTTSTTSEEFYSQLREVRRISGEINAMFK----ENN 1054
            |.|:|..||.|:.....:: ::.||||.|.|...:|.:::..|...|:||..|..|.:    .|.
  Fly  1013 GHAAYGGAVRYSNSHERLN-IEASYFMAYHTILKSSADYFLALESARKISANITQMLQGRLMSNG 1076

  Fly  1055 V------DAEIFAYCVFYIYYEQYLTIWGDAMFSLGMSLVAIFLVTLLITGLDITSTFIVLFMVI 1113
            |      ..|:|.|.|||::||||||:|.|.:.|:|:|:::||:||.::.|.|:.|..:|:..:.
  Fly  1077 VPMASALTVEVFPYSVFYVFYEQYLTMWSDTLQSMGISVLSIFVVTFVLMGFDVHSALVVVITIT 1141

  Fly  1114 CILINMLGMMWAWSINLNAISLVNLVVCVGIGVEFVAHIVRSFKRAEGTAQ-ERARHSLNVTGSS 1177
            .|::|:.|:|:.|:|:|||:||||||:.|||.|||.:|:|.||..::..:| :||..||:..|||
  Fly  1142 MIVVNLGGLMYYWNISLNAVSLVNLVMAVGISVEFCSHLVHSFATSKSVSQIDRAADSLSKMGSS 1206

  Fly  1178 VLSGITLTKFAGIVVLGFSNSQIFQVFYFRMYLGIVLIGAAHGLILLPVLLSLLGPPQKLAR 1239
            :.|||||||||||:||.|:.||||||||||||||||:||||||||.||||||.:|.|...||
  Fly  1207 IFSGITLTKFAGILVLAFAKSQIFQVFYFRMYLGIVVIGAAHGLIFLPVLLSYIGAPVSNAR 1268

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Npc1b	NP_608417.2	2A060601	24..1220	CDD:273337	502/1255 (40%)
Npc1a	NP_609357.2	2A060601	33..1261	CDD:273337	512/1267 (40%)