Protein Alignment Npc1b and Npc1

DIOPT Version :10

• Sequence 1: NP_608417.2
• Gene: Npc1b / 33072
• FlyBaseID: FBgn0261675
• Length: 1254
• Species: Drosophila melanogaster
• Sequence 2: NP_705888.2
• Gene: Npc1 / 266732
• RGDID: 628693
• Length: 1278
• Species: Rattus norvegicus
• Alignment Length: 1293
• Identity: 491/1293 - (37%)
• Similarity: 714/1293 - (55%)
• Gaps: 117/1293 - (9%)

  Fly    12 AGAWSQSAEQLGCIWYGQSHM-IGAHWVNKGDTNPARPLNSPTSEAIFAKRCPMLYKEYKGESGE 75
            |..:|||     |:|||:..: .|....|...:.|.:||.....:.: .:.||.|:        .
  Rat    19 AQVFSQS-----CVWYGECGVAFGDKRYNCEYSGPPKPLPKDGYDLV-QELCPGLF--------F 69

  Fly    76 DELSLCCDAAQIETMESGLSQADGVFSRCPTCTRNMALTVCAMTCAKNHTLFL------------ 128
            ..:|||||..|::|::|.|.......||||:|..|:....|.:||:.:.:.||
  Rat    70 GNVSLCCDVQQLQTLKSNLQLPLQFLSRCPSCFYNLMTLFCELTCSPHQSQFLNVTATEDYFDPE 134

  Fly   129 TAYNDTNDAGVDYVKYIDYRLTDDTVSKIYNSCIGIQHTQTGRPAMDLGCGSYNAKTCNYRRWYE 193
            |..|.||      ||.::|.:.....:.:||:|..::...:...|:.|.||. :|:.||...|.|
  Rat   135 TRENKTN------VKELEYYVGRSFANAMYNACRDVEAPSSNEKALGLLCGR-DARACNATNWIE 192

  Fly   194 FMGDVSGDYVPFQINYKWSEDAEEGSNEIYLDLSPLK-----CGESYED-SYACACIDCEESCPL 252
            :|.:......||.|...:|:.:       .|.:.|::     |.||.:: :..|:|.||...|..
  Rat   193 YMFNKDNGQAPFTIIPVFSDLS-------VLGMEPMRNATKGCNESVDEVTGPCSCQDCSAVCGP 250

  Fly   253 TDAPTGPDELWKIAGLYGVTFILALIIACALSFFIFWG-----------------------AFGK 294
            ...|..|...|:|.|| ...:::..:...|.....|.|                       ||..
  Rat   251 KPQPPPPPVPWRILGL-DAMYVIMWVAYMAFLVLFFGGLLAVWCHRRRYFVSEYTPIDSNIAFSS 314

  Fly   295 TSA----PSVCMP--TLFGEFFYHGFRIWGTFCAKHPVIVLALCSWAIAGLSFGIRYMTITTDPV 353
            .|:    .|.|.|  ..|.:.....|..||.||.::|..::......||..|.|:.::.:||:||
  Rat   315 NSSDKGEASCCDPLGVAFDDCLRRMFTKWGAFCVRNPTCIIFFSLVFIAACSSGLVFVQVTTNPV 379

  Fly   354 ELWAGEESQTRIEKDYFDQHFGPFYRTNQMFVKAVNQTYFTHE--TSNGVLNFGPAFEYNFLKEV 416
            |||:...||.|:||:|||:|||||:||.|:.::|.|.:...:|  .|...:.|||......|.:|
  Rat   380 ELWSAPHSQARLEKEYFDKHFGPFFRTEQLIIQAPNSSVHIYEPYPSGADVPFGPPLNKEILHQV 444

  Fly   417 FELQDSIMKLGMADNE---GLDKICYAPVLMAGETPTVDRCAIQSVYGYFQHDMDRFENSYVDSN 478
            .:||.:|..:..:.|.   .|..||.||:     :|....|.|.||..|||:.....:|...|..
  Rat   445 LDLQIAIESITASYNNETVTLQDICVAPL-----SPYNKNCTIMSVLNYFQNSHAVLDNQVGDDF 504

  Fly   479 NYTINYLNQLEDCLRVP-MMED-------CFGTFGGPIEPGIAVGGMPKVAVGEDPDYMLATGLV 535
            ....:|......|:|.| .:.|       |.||||||:.|.:.:||.      :|.:|..||.||
  Rat   505 FVYADYHTHFLYCVRAPASLNDTSLLHGPCLGTFGGPVFPWLVLGGY------DDQNYNNATALV 563

  Fly   536 LTFLGRN-YNDESKLEPNMKWEKLFVDFLRDYKSDRLDIAYMAERSIQDAIVELSEGEVSTVVIS 599
            :||...| |||..||:....|||.|::|:::||:..|.|::.|||||:|.:...|..:|.||:||
  Rat   564 ITFPVNNYYNDTEKLQRAWAWEKEFINFVKNYKNPNLTISFTAERSIEDELNRESNSDVFTVLIS 628

  Fly   600 YVVMFVYVAIALGHIRSCRGFLRESRIMLAIGGIVIVLASVVCSLGFWGYLDVTTTMLAIEVIPF 664
            |.|||:|:::|||||:|....|.:|:|.|.|.||:|||:||.||||.:.|:.:..|::.||||||
  Rat   629 YAVMFLYISLALGHIQSWNRVLVDSKISLGIAGILIVLSSVTCSLGIFSYIGMPLTLIVIEVIPF 693

  Fly   665 LVLAVGVDNIFIMVHTYQRLDHSKFKTTHEAIGEAIGQVGPSILQTAGSEMACFAIGCISDMPAV 729
            ||||||||||||:|.||||.:..:.:|..:.:|..:|:|.|::..::.||.:.|..|.:|.||||
  Rat   694 LVLAVGVDNIFILVQTYQRDERLQEETLDQQLGRILGEVAPTMFLSSFSETSAFFFGALSSMPAV 758

  Fly   730 KTFAMYAAIAILLDFLLQITAFVALMAIDEKRYLDGRLDMLCCVKSGGKKINDEDGDGVDRPKEV 794
            .||:::|.:|:|:|||||||.||:.:.:|.||....|||:||||:.        ..||.:.....
  Rat   759 HTFSLFAGMAVLIDFLLQITCFVSFLGLDIKRQEKNRLDILCCVRG--------PDDGQESQASE 815

  Fly   795 GLLETLFKNFYSPFLLSKPVKVSVLLIFTVITCLSLMVTPSIEKGLDQEMSMPKNSHVVKYFRYM 859
            ..|...|||.::||||:..::..|:.:|..|...|:.|...:|.||||.:|||.:|:|:.||:.:
  Rat   816 SYLFRFFKNAFAPFLLTDWLRPVVMAVFVGILSFSIAVVNKVEIGLDQSLSMPNDSYVIDYFKSL 880

  Fly   860 VDLLAMGAPVYWVLKPGLNYSEPLQQNLICGGVECNNNSLSVQLYTQAQYPEITSLARPASSWLD 924
            ...|..|.|||:||:.|.|||....||::|||:.|:|:||..|::..|:....|.:....|||:|
  Rat   881 GQYLHSGPPVYFVLEEGYNYSSRRGQNMVCGGMGCDNDSLVQQIFNAAELDTYTRVGFAPSSWID 945

  Fly   925 DYIDWLA-ISDCCK-YNVTTGGFCSSNSKSEDCLPCERGFTENGLRPDAETFNKYIPYFLFDLPD 987
            ||.||:: .|.||: ||| |..||:::.....|:.|.....|...||..:.|.|::|.||.|.|:
  Rat   946 DYFDWVSPQSSCCRLYNV-THQFCNASVIDPTCVRCRPLTPEGKQRPQGKEFMKFLPMFLSDNPN 1009

  Fly   988 AECAKAGRASYADAVIYTIDDVGMSTVQDSYFMQYSTTSTTSEEFYSQLREVRRISGEINAMFKE 1052
            .:|.|.|.|:|:.||....||   :.:..:|||.|.|...||.::...|::.|.|:..|....:.
  Rat  1010 PKCGKGGHAAYSSAVNIMGDD---TYIGATYFMTYHTILKTSADYIDALKKARLIASNITETMRS 1071

  Fly  1053 NNVDAEIFAYCVFYIYYEQYLTIWGDAMFSLGMSLVAIFLVTLLITGLDITSTFIVLFMVICILI 1117
            ...|..:|.|.|||::|||||||..||:|:|.:||.:||||||:..|.::.|..|:...:..||:
  Rat  1072 KGSDYRVFPYSVFYVFYEQYLTIIDDAIFNLSVSLGSIFLVTLVALGCELWSAVIMCLTIAMILV 1136

  Fly  1118 NMLGMMWAWSINLNAISLVNLVVCVGIGVEFVAHIVRSFKRA-EGTAQERARHSLNVTGSSVLSG 1181
            ||.|:||.|.|:|||:||||||:..||.|||.:||.|:|..: :|:...||..:|...||||.||
  Rat  1137 NMFGVMWLWGISLNAVSLVNLVMTCGISVEFCSHITRAFTMSTKGSRVSRAEEALAHMGSSVFSG 1201

  Fly  1182 ITLTKFAGIVVLGFSNSQIFQVFYFRMYLGIVLIGAAHGLILLPVLLSLLGPPQKLAR 1239
            ||||||.|||||.|:.||||::|||||||.:||:||.||||.||||||.:||....|:
  Rat  1202 ITLTKFGGIVVLAFAKSQIFEIFYFRMYLAMVLLGATHGLIFLPVLLSYIGPSVNKAK 1259

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Npc1b	NP_608417.2	2A060601	24..1220	CDD:273337	474/1260 (38%)
Npc1	NP_705888.2	2A060601	26..1252	CDD:273337	484/1272 (38%)