DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Npc1b and Npc1

DIOPT Version :9

Sequence 1:NP_608417.2 Gene:Npc1b / 33072 FlyBaseID:FBgn0261675 Length:1254 Species:Drosophila melanogaster
Sequence 2:NP_705888.2 Gene:Npc1 / 266732 RGDID:628693 Length:1278 Species:Rattus norvegicus


Alignment Length:1293 Identity:491/1293 - (37%)
Similarity:714/1293 - (55%) Gaps:117/1293 - (9%)


- Green bases have known domain annotations that are detailed below.


  Fly    12 AGAWSQSAEQLGCIWYGQSHM-IGAHWVNKGDTNPARPLNSPTSEAIFAKRCPMLYKEYKGESGE 75
            |..:|||     |:|||:..: .|....|...:.|.:||.....:.: .:.||.|:        .
  Rat    19 AQVFSQS-----CVWYGECGVAFGDKRYNCEYSGPPKPLPKDGYDLV-QELCPGLF--------F 69

  Fly    76 DELSLCCDAAQIETMESGLSQADGVFSRCPTCTRNMALTVCAMTCAKNHTLFL------------ 128
            ..:|||||..|::|::|.|.......||||:|..|:....|.:||:.:.:.||            
  Rat    70 GNVSLCCDVQQLQTLKSNLQLPLQFLSRCPSCFYNLMTLFCELTCSPHQSQFLNVTATEDYFDPE 134

  Fly   129 TAYNDTNDAGVDYVKYIDYRLTDDTVSKIYNSCIGIQHTQTGRPAMDLGCGSYNAKTCNYRRWYE 193
            |..|.||      ||.::|.:.....:.:||:|..::...:...|:.|.||. :|:.||...|.|
  Rat   135 TRENKTN------VKELEYYVGRSFANAMYNACRDVEAPSSNEKALGLLCGR-DARACNATNWIE 192

  Fly   194 FMGDVSGDYVPFQINYKWSEDAEEGSNEIYLDLSPLK-----CGESYED-SYACACIDCEESCPL 252
            :|.:......||.|...:|:.:       .|.:.|::     |.||.:: :..|:|.||...|..
  Rat   193 YMFNKDNGQAPFTIIPVFSDLS-------VLGMEPMRNATKGCNESVDEVTGPCSCQDCSAVCGP 250

  Fly   253 TDAPTGPDELWKIAGLYGVTFILALIIACALSFFIFWG-----------------------AFGK 294
            ...|..|...|:|.|| ...:::..:...|.....|.|                       ||..
  Rat   251 KPQPPPPPVPWRILGL-DAMYVIMWVAYMAFLVLFFGGLLAVWCHRRRYFVSEYTPIDSNIAFSS 314

  Fly   295 TSA----PSVCMP--TLFGEFFYHGFRIWGTFCAKHPVIVLALCSWAIAGLSFGIRYMTITTDPV 353
            .|:    .|.|.|  ..|.:.....|..||.||.::|..::......||..|.|:.::.:||:||
  Rat   315 NSSDKGEASCCDPLGVAFDDCLRRMFTKWGAFCVRNPTCIIFFSLVFIAACSSGLVFVQVTTNPV 379

  Fly   354 ELWAGEESQTRIEKDYFDQHFGPFYRTNQMFVKAVNQTYFTHE--TSNGVLNFGPAFEYNFLKEV 416
            |||:...||.|:||:|||:|||||:||.|:.::|.|.:...:|  .|...:.|||......|.:|
  Rat   380 ELWSAPHSQARLEKEYFDKHFGPFFRTEQLIIQAPNSSVHIYEPYPSGADVPFGPPLNKEILHQV 444

  Fly   417 FELQDSIMKLGMADNE---GLDKICYAPVLMAGETPTVDRCAIQSVYGYFQHDMDRFENSYVDSN 478
            .:||.:|..:..:.|.   .|..||.||:     :|....|.|.||..|||:.....:|...|..
  Rat   445 LDLQIAIESITASYNNETVTLQDICVAPL-----SPYNKNCTIMSVLNYFQNSHAVLDNQVGDDF 504

  Fly   479 NYTINYLNQLEDCLRVP-MMED-------CFGTFGGPIEPGIAVGGMPKVAVGEDPDYMLATGLV 535
            ....:|......|:|.| .:.|       |.||||||:.|.:.:||.      :|.:|..||.||
  Rat   505 FVYADYHTHFLYCVRAPASLNDTSLLHGPCLGTFGGPVFPWLVLGGY------DDQNYNNATALV 563

  Fly   536 LTFLGRN-YNDESKLEPNMKWEKLFVDFLRDYKSDRLDIAYMAERSIQDAIVELSEGEVSTVVIS 599
            :||...| |||..||:....|||.|::|:::||:..|.|::.|||||:|.:...|..:|.||:||
  Rat   564 ITFPVNNYYNDTEKLQRAWAWEKEFINFVKNYKNPNLTISFTAERSIEDELNRESNSDVFTVLIS 628

  Fly   600 YVVMFVYVAIALGHIRSCRGFLRESRIMLAIGGIVIVLASVVCSLGFWGYLDVTTTMLAIEVIPF 664
            |.|||:|:::|||||:|....|.:|:|.|.|.||:|||:||.||||.:.|:.:..|::.||||||
  Rat   629 YAVMFLYISLALGHIQSWNRVLVDSKISLGIAGILIVLSSVTCSLGIFSYIGMPLTLIVIEVIPF 693

  Fly   665 LVLAVGVDNIFIMVHTYQRLDHSKFKTTHEAIGEAIGQVGPSILQTAGSEMACFAIGCISDMPAV 729
            ||||||||||||:|.||||.:..:.:|..:.:|..:|:|.|::..::.||.:.|..|.:|.||||
  Rat   694 LVLAVGVDNIFILVQTYQRDERLQEETLDQQLGRILGEVAPTMFLSSFSETSAFFFGALSSMPAV 758

  Fly   730 KTFAMYAAIAILLDFLLQITAFVALMAIDEKRYLDGRLDMLCCVKSGGKKINDEDGDGVDRPKEV 794
            .||:::|.:|:|:|||||||.||:.:.:|.||....|||:||||:.        ..||.:.....
  Rat   759 HTFSLFAGMAVLIDFLLQITCFVSFLGLDIKRQEKNRLDILCCVRG--------PDDGQESQASE 815

  Fly   795 GLLETLFKNFYSPFLLSKPVKVSVLLIFTVITCLSLMVTPSIEKGLDQEMSMPKNSHVVKYFRYM 859
            ..|...|||.::||||:..::..|:.:|..|...|:.|...:|.||||.:|||.:|:|:.||:.:
  Rat   816 SYLFRFFKNAFAPFLLTDWLRPVVMAVFVGILSFSIAVVNKVEIGLDQSLSMPNDSYVIDYFKSL 880

  Fly   860 VDLLAMGAPVYWVLKPGLNYSEPLQQNLICGGVECNNNSLSVQLYTQAQYPEITSLARPASSWLD 924
            ...|..|.|||:||:.|.|||....||::|||:.|:|:||..|::..|:....|.:....|||:|
  Rat   881 GQYLHSGPPVYFVLEEGYNYSSRRGQNMVCGGMGCDNDSLVQQIFNAAELDTYTRVGFAPSSWID 945

  Fly   925 DYIDWLA-ISDCCK-YNVTTGGFCSSNSKSEDCLPCERGFTENGLRPDAETFNKYIPYFLFDLPD 987
            ||.||:: .|.||: ||| |..||:::.....|:.|.....|...||..:.|.|::|.||.|.|:
  Rat   946 DYFDWVSPQSSCCRLYNV-THQFCNASVIDPTCVRCRPLTPEGKQRPQGKEFMKFLPMFLSDNPN 1009

  Fly   988 AECAKAGRASYADAVIYTIDDVGMSTVQDSYFMQYSTTSTTSEEFYSQLREVRRISGEINAMFKE 1052
            .:|.|.|.|:|:.||....||   :.:..:|||.|.|...||.::...|::.|.|:..|....:.
  Rat  1010 PKCGKGGHAAYSSAVNIMGDD---TYIGATYFMTYHTILKTSADYIDALKKARLIASNITETMRS 1071

  Fly  1053 NNVDAEIFAYCVFYIYYEQYLTIWGDAMFSLGMSLVAIFLVTLLITGLDITSTFIVLFMVICILI 1117
            ...|..:|.|.|||::|||||||..||:|:|.:||.:||||||:..|.::.|..|:...:..||:
  Rat  1072 KGSDYRVFPYSVFYVFYEQYLTIIDDAIFNLSVSLGSIFLVTLVALGCELWSAVIMCLTIAMILV 1136

  Fly  1118 NMLGMMWAWSINLNAISLVNLVVCVGIGVEFVAHIVRSFKRA-EGTAQERARHSLNVTGSSVLSG 1181
            ||.|:||.|.|:|||:||||||:..||.|||.:||.|:|..: :|:...||..:|...||||.||
  Rat  1137 NMFGVMWLWGISLNAVSLVNLVMTCGISVEFCSHITRAFTMSTKGSRVSRAEEALAHMGSSVFSG 1201

  Fly  1182 ITLTKFAGIVVLGFSNSQIFQVFYFRMYLGIVLIGAAHGLILLPVLLSLLGPPQKLAR 1239
            ||||||.|||||.|:.||||::|||||||.:||:||.||||.||||||.:||....|:
  Rat  1202 ITLTKFGGIVVLAFAKSQIFEIFYFRMYLAMVLLGATHGLIFLPVLLSYIGPSVNKAK 1259

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Npc1bNP_608417.2 2A060601 24..1220 CDD:273337 474/1260 (38%)
NPC1_N 24..270 CDD:293023 72/264 (27%)
nitrilase <265..>331 CDD:299711 19/94 (20%)
Sterol-sensing 623..775 CDD:289145 78/151 (52%)
Npc1NP_705888.2 NPC1_N 24..268 CDD:293023 74/272 (27%)
2A060601 26..1252 CDD:273337 484/1272 (38%)
Sterol-sensing 650..803 CDD:289145 78/152 (51%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1933
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG55095
OrthoDB 1 1.010 - - D31089at33208
OrthoFinder 1 1.000 - - FOG0001659
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_101370
Panther 1 1.100 - - O PTHR45727
Phylome 1 0.910 - -
SonicParanoid 1 1.000 - - X943
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
1110.790

Return to query results.
Submit another query.