Protein Alignment Npc1b and Npc1l1

DIOPT Version :10

• Sequence 1: NP_608417.2
• Gene: Npc1b / 33072
• FlyBaseID: FBgn0261675
• Length: 1254
• Species: Drosophila melanogaster
• Sequence 2: NP_997125.2
• Gene: Npc1l1 / 237636
• MGIID: 2685089
• Length: 1333
• Species: Mus musculus
• Alignment Length: 1293
• Identity: 443/1293 - (34%)
• Similarity: 679/1293 - (52%)
• Gaps: 153/1293 - (11%)

  Fly    45 PARPLNSPTSE--AIFAKRCPMLYKEYKGESGEDELSLCCDAAQIETMESGLSQADGVFSRCPTC 107
            |||.:   |.:  |:..:.||.||      :|.::...||...|:.:::|.||....:.:|||.|
Mouse    61 PARHV---TGDHLALLQRVCPRLY------NGPNDTYACCSTKQLVSLDSSLSITKALLTRCPAC 116

  Fly   108 TRNMALTVCAMTCAKNHTLFLTAYNDT----NDAG-----VDYVKYIDYRLTDDTVSKIYNSCIG 163
            :.|.....|..||:.:.:||:   |.|    .|.|     |.|..:......:    |.|.||..
Mouse   117 SENFVSIHCHNTCSPDQSLFI---NVTRVVQRDPGQLPAVVAYEAFYQRSFAE----KAYESCSR 174

  Fly   164 IQHTQTGRPAMDLGCGSYNAKTCNYRRWYEFMGDVSGDYVPFQINYKWSEDAE---EGSNEIYLD 225
            ::.......|:...||.|.:..||.:||..|.||......|..|.:...|..:   :|...:...
Mouse   175 VRIPAAASLAVGSMCGVYGSALCNAQRWLNFQGDTGNGLAPLDITFHLLEPGQALADGMKPLDGK 239

  Fly   226 LSPLKCGESY-EDSYACACIDCEESCPLTDAPTGPDELWKIAGLYGVTFILALIIACALSFFIFW 289
            ::|  |.||. |||.||:|.||..|||:...|......:.:..:.|   .|||||       ||.
Mouse   240 ITP--CNESQGEDSAACSCQDCAASCPVIPPPPALRPSFYMGRMPG---WLALII-------IFT 292

  Fly   290 GAF----------------------GKTSAPSVCMP--------TLFGEFFYHGFRIWGTFCAKH 324
            ..|                      |...||:  :|        |:.|.|    |..|||..|..
Mouse   293 AVFVLLSVVLVYLRVASNRNKNKTAGSQEAPN--LPRKRRFSPHTVLGRF----FESWGTRVASW 351

  Fly   325 PVIVLALCSWAIAGLSFGIRYMTITTDPVELWAGEESQTRIEKDYFDQHFGPFYRTNQMFVKAVN 389
            |:.||||....:..||.|:.::.:||||||||:..:||.|.||.:.|:|||||:||||:||.|.|
Mouse   352 PLTVLALSFIVVIALSVGLTFIELTTDPVELWSAPKSQARKEKAFHDEHFGPFFRTNQIFVTAKN 416

  Fly   390 QTYFTHET-SNGVLNFGPAFEYNFLKEVFELQDSIMKLGMADNE-----GLDKICYAPVLMAGET 448
            ::.:.::: ..|..||......:.|:|:.|||:.:..|.:..:|     .|..||||| |....|
Mouse   417 RSSYKYDSLLLGPKNFSGILSLDLLQELLELQERLRHLQVWSHEAQRNISLQDICYAP-LKPHNT 480

  Fly   449 PTVDRCAIQSVYGYFQHDMDRFENSYVDSNNYTINYLNQLED-------CLRVPMME-------- 498
            ...| |.:.|:..|||::    ....:.:.|.|:|....|.|       |...|:..
Mouse   481 SLTD-CCVNSLLQYFQNN----HTLLLLTANQTLNGQTSLVDWKDHFLYCANAPLTYKDGTALAL 540

  Fly   499 DCFGTFGGPIEPGIAVGGMPKVAVGEDPDYMLATGLVLTFLGRNY-NDESKLEPNMKWEKLFVDF 562
            .|...:|.|:.|.:||||.      :..||..|..|::||...|| .|:.::.....||:.|:..
Mouse   541 SCIADYGAPVFPFLAVGGY------QGTDYSEAEALIITFSINNYPADDPRMAHAKLWEEAFLKE 599

  Fly   563 LRDYK---SDRLDIAYMAERSIQDAIVELSEGEVSTVVISYVVMFVYVAIALGHIRSCRGFLRES 624
            ::.::   :|:..||:.||||::|.|...:..::....|||:::|:|:::|||..........:|
Mouse   600 MQSFQRSTADKFQIAFSAERSLEDEINRTTIQDLPVFAISYLIVFLYISLALGSYSRWSRVAVDS 664

  Fly   625 RIMLAIGGIVIVLASVVCSLGFWGYLDVTTTMLAIEVIPFLVLAVGVDNIFIMVHTYQRLDHSKF 689
            :..|.:||:.:||.:||.::||:.||.|.::::.|:|:||||||||.|||||.|..||||.....
Mouse   665 KATLGLGGVAVVLGAVVAAMGFYSYLGVPSSLVIIQVVPFLVLAVGADNIFIFVLEYQRLPRMPG 729

  Fly   690 KTTHEAIGEAIGQVGPSILQTAGSEMACFAIGCISDMPAVKTFAMYAAIAILLDFLLQITAFVAL 754
            :.....||..:|.|.||:|..:.||..||.:|.::.||||:|||:.:.:||:.|||||:||||||
Mouse   730 EQREAHIGRTLGSVAPSMLLCSLSEAICFFLGALTSMPAVRTFALTSGLAIIFDFLLQMTAFVAL 794

  Fly   755 MAIDEKRYLDGRLDMLCCVKSGGKKINDEDGDGVDRPKE-VGLLETLFKNFYSPFLLSKPVKVSV 818
            :::|.||....|.|::||..|          ..:..||: .|||...|:..|:||||.:.::..|
Mouse   795 LSLDSKRQEASRPDVVCCFSS----------RNLPPPKQKEGLLLCFFRKIYTPFLLHRFIRPVV 849

  Fly   819 LLIFTVITCLSLMVTPSIEKGLDQEMSMPKNSHVVKYFRYMVDLLAMGAPVYWVLKPGLNYSEPL 883
            ||:|.|:...:|.:..:|..||||::::||:|:::.||.::...|.:|.|||:....|.|:|...
Mouse   850 LLLFLVLFGANLYLMCNISVGLDQDLALPKDSYLIDYFLFLNRYLEVGPPVYFDTTSGYNFSTEA 914

  Fly   884 QQNLICGGVECNNNSLSVQLYTQAQYPEITSLARPASSWLDDYIDWLA-ISDCCKYNVTTGG--- 944
            ..|.||....|.:.||:.::...:::|..:.:|..||||:||:||||. .|.||:  :.|.|
Mouse   915 GMNAICSSAGCESFSLTQKIQYASEFPNQSYVAIAASSWVDDFIDWLTPSSSCCR--IYTRGPHK 977

  Fly   945 --FCSSNSKSEDCLPCERGFTENGLRPDAETFNKYIPYFLFDLPDAECAKAGRASYADAVIYTID 1007
              ||.|...|.:||......|...:||..|.|:||:|:||.|.|:..|.|.|.|:|..:|..:.|
Mouse   978 DEFCPSTDTSFNCLKNCMNRTLGPVRPTTEQFHKYLPWFLNDTPNIRCPKGGLAAYRTSVNLSSD 1042

  Fly  1008 DVGMSTVQDSYFMQYSTTSTTSEEFYSQLREVRRISGEINAMFKE---NNVDAEIFAYCVFYIYY 1069
                ..:..|.||.|......|::|...||..|.::..|.|..::   .:.:.|:|.|.:..::|
Mouse  1043 ----GQIIASQFMAYHKPLRNSQDFTEALRASRLLAANITAELRKVPGTDPNFEVFPYTISNVFY 1103

  Fly  1070 EQYLTIWGDAMFSLGMSLVAIFLVTLLITGLDITSTFIVLFMVICILINMLGMMWAWSINLNAIS 1134
            :||||:..:.:|:|.:..|..|:|..|:.||||.|..:.|..:|.||::.:|:|..|.|:.||:|
Mouse  1104 QQYLTVLPEGIFTLALCFVPTFVVCYLLLGLDIRSGILNLLSIIMILVDTIGLMAVWGISYNAVS 1168

  Fly  1135 LVNLVVCVGIGVEFVAHIVRSFK-RAEGTAQERARHSLNVTGSSVLSGITLTKFAGIVVLGFSNS 1198
            |:|||..||:.||||:||.|||. ..:.|..|||:.:....||:|.:|:.:|.|.||::|||:.:
Mouse  1169 LINLVTAVGMSVEFVSHITRSFAVSTKPTRLERAKDATIFMGSAVFAGVAMTNFPGILILGFAQA 1233

  Fly  1199 QIFQVFYFRMYLGIVLIGAAHGLILLPVLLSLLGP--------PQKLARSSG--AEPT 1246
            |:.|:|:||:.|.|.|:|..|||:.|||:||.|||        .:|||..:.  :||:
Mouse  1234 QLIQIFFFRLNLLITLLGLLHGLVFLPVVLSYLGPDVNQALVLEEKLATEAAMVSEPS 1291

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Npc1b	NP_608417.2	2A060601	24..1220	CDD:273337	427/1255 (34%)
Npc1l1	NP_997125.2	2A060601	32..1267	CDD:273337	435/1267 (34%)