DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Npc1b and Npc1l1

DIOPT Version :9

Sequence 1:	NP_608417.2	Gene:	Npc1b / 33072	FlyBaseID:	FBgn0261675	Length:	1254	Species:	Drosophila melanogaster
Sequence 2:	NP_997125.2	Gene:	Npc1l1 / 237636	MGIID:	2685089	Length:	1333	Species:	Mus musculus

Alignment Length:	1293	Identity:	443/1293 - (34%)
Similarity:	679/1293 - (52%)	Gaps:	153/1293 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 PARPLNSPTSE--AIFAKRCPMLYKEYKGESGEDELSLCCDAAQIETMESGLSQADGVFSRCPTC 107
            |||.:   |.:  |:..:.||.||      :|.::...||...|:.:::|.||....:.:|||.|
Mouse    61 PARHV---TGDHLALLQRVCPRLY------NGPNDTYACCSTKQLVSLDSSLSITKALLTRCPAC 116

  Fly   108 TRNMALTVCAMTCAKNHTLFLTAYNDT----NDAG-----VDYVKYIDYRLTDDTVSKIYNSCIG 163
            :.|.....|..||:.:.:||:   |.|    .|.|     |.|..:......:    |.|.||..
Mouse   117 SENFVSIHCHNTCSPDQSLFI---NVTRVVQRDPGQLPAVVAYEAFYQRSFAE----KAYESCSR 174

  Fly   164 IQHTQTGRPAMDLGCGSYNAKTCNYRRWYEFMGDVSGDYVPFQINYKWSEDAE---EGSNEIYLD 225
            ::.......|:...||.|.:..||.:||..|.||......|..|.:...|..:   :|...:...
Mouse   175 VRIPAAASLAVGSMCGVYGSALCNAQRWLNFQGDTGNGLAPLDITFHLLEPGQALADGMKPLDGK 239

  Fly   226 LSPLKCGESY-EDSYACACIDCEESCPLTDAPTGPDELWKIAGLYGVTFILALIIACALSFFIFW 289
            ::|  |.||. |||.||:|.||..|||:...|......:.:..:.|   .|||||       ||.
Mouse   240 ITP--CNESQGEDSAACSCQDCAASCPVIPPPPALRPSFYMGRMPG---WLALII-------IFT 292

  Fly   290 GAF----------------------GKTSAPSVCMP--------TLFGEFFYHGFRIWGTFCAKH 324
            ..|                      |...||:  :|        |:.|.|    |..|||..|..
Mouse   293 AVFVLLSVVLVYLRVASNRNKNKTAGSQEAPN--LPRKRRFSPHTVLGRF----FESWGTRVASW 351

  Fly   325 PVIVLALCSWAIAGLSFGIRYMTITTDPVELWAGEESQTRIEKDYFDQHFGPFYRTNQMFVKAVN 389
            |:.||||....:..||.|:.::.:||||||||:..:||.|.||.:.|:|||||:||||:||.|.|
Mouse   352 PLTVLALSFIVVIALSVGLTFIELTTDPVELWSAPKSQARKEKAFHDEHFGPFFRTNQIFVTAKN 416

  Fly   390 QTYFTHET-SNGVLNFGPAFEYNFLKEVFELQDSIMKLGMADNE-----GLDKICYAPVLMAGET 448
            ::.:.::: ..|..||......:.|:|:.|||:.:..|.:..:|     .|..||||| |....|
Mouse   417 RSSYKYDSLLLGPKNFSGILSLDLLQELLELQERLRHLQVWSHEAQRNISLQDICYAP-LKPHNT 480

  Fly   449 PTVDRCAIQSVYGYFQHDMDRFENSYVDSNNYTINYLNQLED-------CLRVPMME-------- 498
            ...| |.:.|:..|||::    ....:.:.|.|:|....|.|       |...|:..
Mouse   481 SLTD-CCVNSLLQYFQNN----HTLLLLTANQTLNGQTSLVDWKDHFLYCANAPLTYKDGTALAL 540

  Fly   499 DCFGTFGGPIEPGIAVGGMPKVAVGEDPDYMLATGLVLTFLGRNY-NDESKLEPNMKWEKLFVDF 562
            .|...:|.|:.|.:||||.      :..||..|..|::||...|| .|:.::.....||:.|:..
Mouse   541 SCIADYGAPVFPFLAVGGY------QGTDYSEAEALIITFSINNYPADDPRMAHAKLWEEAFLKE 599

  Fly   563 LRDYK---SDRLDIAYMAERSIQDAIVELSEGEVSTVVISYVVMFVYVAIALGHIRSCRGFLRES 624
            ::.::   :|:..||:.||||::|.|...:..::....|||:::|:|:::|||..........:|
Mouse   600 MQSFQRSTADKFQIAFSAERSLEDEINRTTIQDLPVFAISYLIVFLYISLALGSYSRWSRVAVDS 664

  Fly   625 RIMLAIGGIVIVLASVVCSLGFWGYLDVTTTMLAIEVIPFLVLAVGVDNIFIMVHTYQRLDHSKF 689
            :..|.:||:.:||.:||.::||:.||.|.::::.|:|:||||||||.|||||.|..||||.....
Mouse   665 KATLGLGGVAVVLGAVVAAMGFYSYLGVPSSLVIIQVVPFLVLAVGADNIFIFVLEYQRLPRMPG 729

  Fly   690 KTTHEAIGEAIGQVGPSILQTAGSEMACFAIGCISDMPAVKTFAMYAAIAILLDFLLQITAFVAL 754
            :.....||..:|.|.||:|..:.||..||.:|.::.||||:|||:.:.:||:.|||||:||||||
Mouse   730 EQREAHIGRTLGSVAPSMLLCSLSEAICFFLGALTSMPAVRTFALTSGLAIIFDFLLQMTAFVAL 794

  Fly   755 MAIDEKRYLDGRLDMLCCVKSGGKKINDEDGDGVDRPKE-VGLLETLFKNFYSPFLLSKPVKVSV 818
            :::|.||....|.|::||..|          ..:..||: .|||...|:..|:||||.:.::..|
Mouse   795 LSLDSKRQEASRPDVVCCFSS----------RNLPPPKQKEGLLLCFFRKIYTPFLLHRFIRPVV 849

  Fly   819 LLIFTVITCLSLMVTPSIEKGLDQEMSMPKNSHVVKYFRYMVDLLAMGAPVYWVLKPGLNYSEPL 883
            ||:|.|:...:|.:..:|..||||::::||:|:::.||.::...|.:|.|||:....|.|:|...
Mouse   850 LLLFLVLFGANLYLMCNISVGLDQDLALPKDSYLIDYFLFLNRYLEVGPPVYFDTTSGYNFSTEA 914

  Fly   884 QQNLICGGVECNNNSLSVQLYTQAQYPEITSLARPASSWLDDYIDWLA-ISDCCKYNVTTGG--- 944
            ..|.||....|.:.||:.::...:::|..:.:|..||||:||:||||. .|.||:  :.|.|
Mouse   915 GMNAICSSAGCESFSLTQKIQYASEFPNQSYVAIAASSWVDDFIDWLTPSSSCCR--IYTRGPHK 977

  Fly   945 --FCSSNSKSEDCLPCERGFTENGLRPDAETFNKYIPYFLFDLPDAECAKAGRASYADAVIYTID 1007
              ||.|...|.:||......|...:||..|.|:||:|:||.|.|:..|.|.|.|:|..:|..:.|
Mouse   978 DEFCPSTDTSFNCLKNCMNRTLGPVRPTTEQFHKYLPWFLNDTPNIRCPKGGLAAYRTSVNLSSD 1042

  Fly  1008 DVGMSTVQDSYFMQYSTTSTTSEEFYSQLREVRRISGEINAMFKE---NNVDAEIFAYCVFYIYY 1069
                ..:..|.||.|......|::|...||..|.::..|.|..::   .:.:.|:|.|.:..::|
Mouse  1043 ----GQIIASQFMAYHKPLRNSQDFTEALRASRLLAANITAELRKVPGTDPNFEVFPYTISNVFY 1103

  Fly  1070 EQYLTIWGDAMFSLGMSLVAIFLVTLLITGLDITSTFIVLFMVICILINMLGMMWAWSINLNAIS 1134
            :||||:..:.:|:|.:..|..|:|..|:.||||.|..:.|..:|.||::.:|:|..|.|:.||:|
Mouse  1104 QQYLTVLPEGIFTLALCFVPTFVVCYLLLGLDIRSGILNLLSIIMILVDTIGLMAVWGISYNAVS 1168

  Fly  1135 LVNLVVCVGIGVEFVAHIVRSFK-RAEGTAQERARHSLNVTGSSVLSGITLTKFAGIVVLGFSNS 1198
            |:|||..||:.||||:||.|||. ..:.|..|||:.:....||:|.:|:.:|.|.||::|||:.:
Mouse  1169 LINLVTAVGMSVEFVSHITRSFAVSTKPTRLERAKDATIFMGSAVFAGVAMTNFPGILILGFAQA 1233

  Fly  1199 QIFQVFYFRMYLGIVLIGAAHGLILLPVLLSLLGP--------PQKLARSSG--AEPT 1246
            |:.|:|:||:.|.|.|:|..|||:.|||:||.|||        .:|||..:.  :||:
Mouse  1234 QLIQIFFFRLNLLITLLGLLHGLVFLPVVLSYLGPDVNQALVLEEKLATEAAMVSEPS 1291

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Npc1b	NP_608417.2	2A060601	24..1220	CDD:273337	427/1255 (34%)
		NPC1_N	24..270	CDD:293023	67/239 (28%)
		nitrilase	<265..>331	CDD:299711	24/95 (25%)
		Sterol-sensing	623..775	CDD:289145	72/151 (48%)
Npc1l1	NP_997125.2	NPC1_N	30..283	CDD:293023	67/239 (28%)
		2A060601	32..1267	CDD:273337	435/1267 (34%)
		Sterol-sensing	684..815	CDD:289145	64/130 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1933
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55095
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001659
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101370
Panther	1	1.100	-	-	O	PTHR45727
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X943
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	8	7.780