Protein Alignment Npc1b and Scap

DIOPT Version :9

• Sequence 1: NP_608417.2
• Gene: Npc1b / 33072
• FlyBaseID: FBgn0261675
• Length: 1254
• Species: Drosophila melanogaster
• Sequence 2: NP_001001144.2
• Gene: Scap / 235623
• MGIID: 2135958
• Length: 1276
• Species: Mus musculus
• Alignment Length: 632
• Identity: 127/632 - (20%)
• Similarity: 246/632 - (38%)
• Gaps: 165/632 - (26%)

  Fly   309 FFYHGFRIWGTFCAKHPVIVLALCSWAIAGLSFGIRYMTIT-TDPVELWA--------------- 357
            |:.||.     .||.:|:.::......|....:.:..:.:. |.|||...
Mouse    15 FYNHGL-----LCASYPIPIILFTGLCILACCYPLLKLPLPGTGPVEFSTPVKGYSPPPADSDHK 74

  Fly   358 -GEESQTRIEKDYFDQHFGPFYRTNQMFVKAVNQTYFTHETSNGVLNFGPAFEYNFLKEVFELQD 421
             ||.|:   :.:::..  .|.....|:|||:....:..:..:..|.. .|      |...|:|.:
Mouse    75 QGEPSE---QPEWYVG--APVAYIQQIFVKSSVSPWHRNLLAVDVFR-SP------LSRAFQLVE 127

  Fly   422 SIMKLGMADNEG---LDKICYAPVLMAGETPTVDR---------CAIQSVYGYFQHDMDRFENSY 474
            .|....:.|:.|   |:::|   :.:....|.:.:         |.:.|...::|:|.:||   :
Mouse   128 EIRNHVLRDSSGTKSLEEVC---LQVTDLLPGLRKLRSLLPEHGCLLLSPGNFWQNDWERF---H 186

  Fly   475 VDSNNYTINYLNQ-----------LEDCLRVPMMEDCFGTFGGPIE-PGIAVGGMPKVAVGEDPD 527
            .|.:  .|..::|           |:|.|           ||.|.: .|:::....:
Mouse   187 ADPD--IIGTIHQHEPKTLQTSATLKDLL-----------FGVPGKYSGVSLYTRKR-------- 230

  Fly   528 YMLATGLVLTFLGRNYNDESKLEPNMKWEKLFVDFLR------------DYKSDRLDIAYMAERS 580
             |::..:.|.|              .::...|:..||            ..:::.|...:..|
Mouse   231 -MVSYTITLVF--------------QRYHAKFLSSLRARLMLLHPSPNCSLRAENLVHVHFKE-- 278

  Fly   581 IQDAIVELSEGEVSTVVISYVVMFVYVAIALGHIRSCRGFLRESRIMLAIGGIVIVLASVVCSLG 645
                  |:...|:..:|.:|:::|.|:..:...|.     :.:|:..||:..:|.||:|::.|:|
Mouse   279 ------EIGIAELIPLVTTYIILFAYIYFSTRKID-----MVKSKWGLALAAVVTVLSSLLMSVG 332

  Fly   646 FWGYLDVTTTMLAIEVIPFLVLAVGVDNIFIM----VHTYQRLDHSKFKTTHEAIGEAIGQVGPS 706
            ......:|.|:...|:.|:||:.:|::|:.::    |.|...|: .|.:     |.:.:.....|
Mouse   333 LCTLFGLTPTLNGGEIFPYLVVVIGLENVLVLTKSVVSTPVDLE-VKLR-----IAQGLSSESWS 391

  Fly   707 ILQTAGSEMACFAIGCISDMPAVKTFAMYAAIAILLDFLLQITAFVALMAIDEKRY----LDGRL 767
            |::.|.:|:....||..:.:||::.|.::|.:.::.||.||:..|..:::||.:|.    |:.||
Mouse   392 IMKNAATELGIILIGYFTLVPAIQEFCLFAVVGLVSDFFLQMLFFTTVLSIDIRRMELADLNKRL 456

  Fly   768 DMLCCVKSG---GKKINDEDGDGV--DRPKEVGLLETLFKNFYSP-------FLLSKPVKVSVLL 820
            ....|:.|.   |:....|....|  ..|..:.|..:.|:|...|       ||....:...:::
Mouse   457 PPESCLPSAKPVGRPARYERQQAVRPSTPHTITLQPSSFRNLRLPKRLRVIYFLARTRLAQRLIM 521

  Fly   821 IFTVI--------------TCLSLMVTPSIEKGLDQEMSMPKNSHVV 853
            ..||:              |.|:..||.....|......||..|.|:
Mouse   522 AGTVVWIGILVYTDPAGLRTYLAAQVTEQSPLGEGSLGPMPVPSGVL 568

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Npc1b	NP_608417.2	2A060601	24..1220	CDD:273337	127/632 (20%)
		NPC1_N	24..270	CDD:293023
		nitrilase	<265..>331	CDD:299711	6/21 (29%)
		Sterol-sensing	623..775	CDD:289145	44/159 (28%)
Scap	NP_001001144.2	2A060601	<11..>466	CDD:273337	106/528 (20%)
		Loop-1. /evidence=ECO:0000250|UniProtKB:P97260	46..284		48/299 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	60..81		3/23 (13%)
		Sterol-sensing	308..454	CDD:372063	41/151 (27%)
		ER export signal. /evidence=ECO:0000250|UniProtKB:P97260	447..452		0/4 (0%)
		Loop-7. /evidence=ECO:0000250|UniProtKB:P97260	535..710		9/34 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	669..698
		Interaction with SREBF2. /evidence=ECO:0000250|UniProtKB:P97260	731..1276
		WD40	771..802	CDD:197651
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	834..903
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	927..960
		WD40 repeat	957..998	CDD:293791
		WD40 repeat	1008..1071	CDD:293791
		WD40	1065..>1232	CDD:392136
		WD40 repeat	1079..1113	CDD:293791
		WD40 repeat	1120..1154	CDD:293791
		WD40 repeat	1160..1194	CDD:293791

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1933
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810