Protein Alignment Npc1b and ptr-22

DIOPT Version :9

• Sequence 1: NP_608417.2
• Gene: Npc1b / 33072
• FlyBaseID: FBgn0261675
• Length: 1254
• Species: Drosophila melanogaster
• Sequence 2: NP_001256834.1
• Gene: ptr-22 / 191753
• WormBaseID: WBGene00004236
• Length: 888
• Species: Caenorhabditis elegans
• Alignment Length: 1021
• Identity: 222/1021 - (21%)
• Similarity: 379/1021 - (37%)
• Gaps: 257/1021 - (25%)

  Fly   308 EFFYHGFRIWGTFCAKHP---VIVLALCSWAIAGLSFGIRYMTITTDPVELWAGEESQTRIEKDY 369
            :|||.    .|.|...||   :.||.|.: .::.|.| :|:..|....|.
 Worm    14 KFFYK----VGYFVGTHPRKCIGVLLLVT-LVSCLGF-LRFHQINNARVT--------------- 57

  Fly   370 FDQHFGPFYRTNQMFVKAVNQTYFTH-------ETSNGVLNFGPAFEYNFLKEVFELQDSIMKLG 427
            |..|..|.:....||.:.:.|....|       .:.||.| ..|.:.:    |::|:...|::..
 Worm    58 FTAHDSPSHLEGAMFFEFLRQNGTLHMIEVMFQASDNGSL-LRPPYRH----ELYEISKEIVEKL 117

  Fly   428 MADNEGLDKICYAPVLMAGETPTVDRCAIQSVYG-----YFQHD------MDRFENSYVDSNNYT 481
            ..|..|::|                      .||     |.:.:      ||.||::..||...|
 Worm   118 QVDVNGVNK----------------------TYGDMCEPYCEKNDAFFALMDIFESNSTDSFEIT 160

  Fly   482 INYLNQLEDCLRVPMMEDCFGTFGGP----IEPGIAVGGMPKVAVGEDPDYMLATGLVLTFLGRN 542
            ......|..  ::.:..:.:|....|    |:...||                .....|||
 Worm   161 YPTTELLGH--KILLANNLYGVETHPKTHRIQSFSAV----------------ILRFFLTF---- 203

  Fly   543 YNDESKLEPNMKWEKLFVDFLRD-----YKSDRLDIAY---MAERSIQDAIVELSEGEVSTVVIS 599
                    ||:   |...||..:     |.|.:..:.|   .::..:.:.:..|.......:.::
 Worm   204 --------PNL---KPMTDFEHEIVKLVYDSGKYPLIYGQVASDNLVAEEVRRLGTTTAPWLSVA 257

  Fly   600 YVVMFVYVAIALGHIRSCRGFLRESRIMLAIGGIVIVLASVVCSLGFWGYLDVTTTMLAIEVI-- 662
            ..::.|::.:.     |.|....||:.:.|..|.:|.:.|.:.::|.     |:.|.||.:.|
 Worm   258 LAILGVFLMVC-----SLRYRRAESKPLEACLGALIPVLSGITTIGM-----VSATGLAFQSIIV 312

  Fly   663 --PFLVLAVGVDNIFIMVHTYQRLDHSKFKTTHEAIGEAIGQVGPSILQTAGSEMACFAIGCISD 725
              .|||:|:|:|:|||::..:.|.|  |.....|.:...:.:.|.|:..|..:.:..|..|.:|.
 Worm   313 STLFLVIAIGIDDIFIILAAWHRTD--KHLEIPERMALTVQEAGCSMTVTTVTNLVSFGNGVLST 375

  Fly   726 MPAVKTFAMYAAIAILLDFLLQITAFVALMAIDEKRYLDGRLDMLCCVKSGGKK------INDED 784
            .|.::|||:|:::|.::.::.|:..|.|::||.......         |.|..|      |....
 Worm   376 TPVLQTFAIYSSVASVVCYIYQLVIFPAIIAITAPNEYQ---------KLGDSKEEKTWDIIKTM 431

  Fly   785 GDGVDRP--KEVGLLETLFKNFYSPFLLSKPVKVSVLLIFTVITCLSLMVTPSIEKGLDQEMSMP 847
            |...||.  |..|.:.|.:....:..:|.....:||..|.|:.|.|      :|:|..||
 Worm   432 GQWSDRQWHKLAGAISTSWVRLLTISILLGYWYLSVYGIATMETDL------TIQKMADQ----- 485

  Fly   848 KNSHVVKYFRYM-VDLLAMGAPVYWVLKP-GLNYSEPLQ--QNLICGGVECNNNSLSVQLYTQAQ 908
             |:.:||:.|.. :.|..|.:....|..| .|...|.|:  |.:| ...|...||...:
 Worm   486 -NARIVKFKRDADIILKEMQSVAILVKSPKDLRKMENLKKLQKMI-KDFESAKNSFGNE------ 542

  Fly   909 YPEITSLARPASSWLDDYIDWLAISDCCKYN-----------VTTGGFCSSNSKSEDCLPCERGF 962
                     ....||..|||:|..     |.           :|......||...|........|
 Worm   543 ---------STVCWLQSYIDFLTF-----YQENDEEFDNDDVITENSAKKSNFSEEKPAKSRFQF 593

  Fly   963 TENGLRPDAETFNKYIPYFLFDLPDAECAKAGRASYADAVIYTIDDVGMSTVQDSYFMQYSTTST 1027
            |.:.|.....:..:|.|...:.  ::||.| ......::.|:|   .|.:.|     ::|:
 Worm   594 TYSDLPAFLNSEPQYKPMIRYS--ESECVK-NSEKCIESFIFT---TGFTDV-----VKYN---- 643

  Fly  1028 TSEEFYSQLREVRRISGEINAMFKENNVDAEIFAYCVFYIYYEQYL----TIWGDAMFSLGMSLV 1088
               |.|..:.|.|:|:.        |..:.|::.|.....:.:|.:    .||...     :|.|
 Worm   644 ---EMYPVVSEWRKIAA--------NYSEFEVYPYTERSNFVDQTVDMVDNIWNTV-----ISEV 692

  Fly  1089 AIFLVTLLITGLDITSTFIVLFMVICILINMLGMMWAWSINLNAISLVNLVVCVGIGVEFVAHIV 1153
            ....:|.::...|:.|.|..:|.:..:...:.|.:..|.:.::.:|..:|::.:|..|:..|||.
 Worm   693 ICMGLTFILFIPDLISIFSAVFALFSVNFGVFGFLSIWGVGMDPVSTASLLMSIGFSVDISAHIS 757

  Fly  1154 RSFKRAE-GTAQERARHSLNVTGSSVLSGITLTKFAGI-VVLGFSNSQIFQVFYFRMYLGIVLI- 1215
            ..:.:.: .||:::..|..:..|...|.|...|..|.: :||..|            |||:|.:
 Worm   758 YHYYQVDKPTARQKLEHVYSHIGWPTLQGGLSTMLAMMPIVLAPS------------YLGMVFLK 810

  Fly  1216 --------GAAHGLILLPVLLSLLGPPQKLARSSGAE----PTASI 1249
                    |..||||:|||.||.........|....:    |::||
 Worm   811 TVILVCTFGLIHGLIVLPVFLSFFTEISGFCRRKSVKIADSPSSSI 856

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Npc1b	NP_608417.2	2A060601	24..1220	CDD:273337	209/986 (21%)
		NPC1_N	24..270	CDD:293023
		nitrilase	<265..>331	CDD:299711	9/25 (36%)
		Sterol-sensing	623..775	CDD:289145	42/155 (27%)
ptr-22	NP_001256834.1	Patched	58..835	CDD:355433	203/933 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S1850
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.860