Protein Alignment Npc1b and ptr-21

DIOPT Version :10

• Sequence 1: NP_608417.2
• Gene: Npc1b / 33072
• FlyBaseID: FBgn0261675
• Length: 1254
• Species: Drosophila melanogaster
• Sequence 2: NP_490751.1
• Gene: ptr-21 / 191752
• WormBaseID: WBGene00004235
• Length: 909
• Species: Caenorhabditis elegans
• Alignment Length: 1048
• Identity: 198/1048 - (18%)
• Similarity: 376/1048 - (35%)
• Gaps: 317/1048 - (30%)

  Fly   264 KIAGLYGVTFILALIIACALSFFIFWGAFGKTS-----------APSVCMPTLFGEFFYHGFRIW 317
            ||.|.:.:.||:|.:|.|:       |..|...           .|...:..|..       |::
 Worm    48 KIIGRFPIAFIIATVIMCS-------GGLGTIGLELKDNVRDGYTPKNSLSRLEN-------RLY 98

  Fly   318 GTFCAKH--PVIVLALCSWAIAGLSFGIRYMTITTDPVELWAGEESQTR---IEKDYFDQHFGPF 377
            ..|.:..  ||:...|.:....|....|:|:            ||:|.:   |.|:
 Worm    99 REFLSSEGDPVMTTVLMTAKDGGSMHRIKYL------------EEAQRQWLYISKN--------- 142

  Fly   378 YRTNQMFVKAVNQTYFTHETSNGVLNFGPAFEYNFLKEVFELQDSIMKLGMADNEGLDKIC--YA 440
                           .:.:..||                     ..||.|        ..|  |
 Worm   143 ---------------LSADVGNG---------------------EFMKFG--------DFCGHY- 162

  Fly   441 PVLMAGETPTVDRCAIQSVYGYFQHDMDRFENSYVD--SNNYTINYLNQLEDCLRVPMMEDCFGT 503
                         |....:.|||   :|.::....|  .:.|.:||........::.:..:.||.
 Worm   163 -------------CQANDIIGYF---LDAYKTKSADPKMDGYQLNYPITTVMGYQLHLERNFFGV 211

  Fly   504 FGGPIEPGIAVGGMPKVAVGEDPDYMLATGLVLTFLG--RNYNDESKLEPNMKWEKLFVDFLRDY 566
            .....:|...:..| ||             |.|..|.  |.:.|..||.   |||....::...|
 Worm   212 TVNQSDPVTNIQSM-KV-------------LTLPVLSEVRTFEDTDKLN---KWELAVYNYATGY 259

  Fly   567 KS----DRL-DIAYMAERSIQDAIVELSEGEVSTVVISYVVMFVYVAIALGHIRSCRGFLRESRI 626
            .:    |.| :|..:....:...:.:.::..|...::..|.|.:::...:....|..|:......
 Worm   260 SALEGDDHLVEINVIGAEVVDTEMNKDAQKMVPYFIVGIVSMIIFIFCTVSISASYYGYFSWRIG 324

  Fly   627 MLAIGGIVIVLASVVCSLGFWGYLDVTTTMLAIEVIPFLVLAVGVDNIFIMVHTYQRLDHSKFKT 691
            ::|:..:::.:.:::.:.|....|. ..|...:.::|||:..:||::.|:.:..:  |.||....
 Worm   325 LIALACLLVPILAILTAFGINNMLG-NRTNSPMMIMPFLINGIGVNDAFLTLQNW--LQHSPDLP 386

  Fly   692 THEAIGEAIGQVGPSILQTAGSEMACFAIGCISDMPAVKTFAMYAAIAILLDFLLQITAF--VAL 754
            :.:.:|..:.:.||||..|..:.:..|.||.::....:..|.:..||::||.::..:|.|  |.:
 Worm   387 SGKRLGYMLAEAGPSITTTTLTNVIVFLIGWMNPTEEMSIFCLGCAISLLLAYVYTLTFFCPVLV 451

  Fly   755 MAIDEKRYLDGRLDMLCCVKSGGKKINDEDGDGVDRPKEVGLLETLFK---NFYSPFLLSKPVKV 816
            :.:.|:                           |:.|.:   ||..|.   .||:..:.|: ...
 Worm   452 LLLSER---------------------------VNEPSK---LEGTFNKVLGFYAKIICSR-WTF 485

  Fly   817 SVLLI-------FTVITCLSLMVTPSIEKGLDQEMSMPKNSHVV-----KYFRYMVDLLAMGAPV 869
            ::|:|       |.:...|.:....:..|.|..|..:.|.:.::     |.| |.|.:: :.:||
 Worm   486 ALLIIGSLVYWGFGIYGTLGIRAVLNTAKILPLETPIRKPNRIIEETVWKEF-YPVTVI-VNSPV 548

  Fly   870 YWVLKPGLNYSEPLQ--QNLI--------CGGVECNNNSL-SVQLY------TQAQYPEITSLAR 917
                  .::.:..|:  .||:        |.|.|...:.: ..|.|      ....|.|.|  .:
 Worm   549 ------DISNANALRAFDNLVHDFESMEKCRGSEYTISPIRDYQTYFYGVGAEDFDYEEET--VK 605

  Fly   918 PASSWLDDYIDWLAISDCCKYNVTTGGFCSSNSKSEDCLPCERGFTENGLRPDAETFNKYIPYFL 982
            ..|..||             ::..||...:...|..          :.||:.:   |:..:|...
 Worm   606 NTSHSLD-------------FSKLTGFLANPIYKHH----------KGGLKLN---FSNPVPIRK 644

  Fly   983 FDLPDAECAKAGRASYADAVIYTIDDVGMSTVQDSYFMQYSTTSTTSEEFYSQLREVRRISGEIN 1047
            ..|                 |:..::|                 |:.:|....:::.|.|:
 Worm   645 VQL-----------------IFAYENV-----------------TSWDERIQIMQDWRTIA---- 671

  Fly  1048 AMFKENNVDAEIFAYCVFYIYYEQYLTIWG----DAMFSLG--MSLVAIFLVTLLITGLDITSTF 1106
                .::|...:..:.|..::.:|.|::.|    :|:.:||  .::..:|:...|..||...|
 Worm   672 ----SSHVALNVSVWNVNAMFVDQMLSLKGLAISNALVTLGCMAAVCVVFIRNPLSVGLATAS-- 730

  Fly  1107 IVLFMVICILINMLGMMWAWSINLNAISLVNLVVCVGIGVEFVAHIVRSF-------------KR 1158
                 ::.|.|.:.|.:..|.::|:.::|..::|.:|:.|:||||:...:             ||
 Worm   731 -----ILSISIGVTGYLCFWDLDLDPVTLCAVIVSIGMSVDFVAHVACHYQVRYKEFEEKGVLKR 790

  Fly  1159 AE-GTAQERARHSL-NVTGSSVLSGITLTKFAGIVVLGFSNSQIFQVFYFRMYLGIVLIGAAHGL 1221
            .| .|.:.|..:|| ||....|.|  ..:....::.||...:.:..|| .:..|.:|:.|..|||
 Worm   791 IEMKTPESRVVNSLSNVLWPMVQS--ASSTLLCVLPLGILQNYLPMVF-VKTILLVVIWGMFHGL 852

  Fly  1222 ILLPVLLS 1229
            :|||.:|:
 Worm   853 VLLPCILA 860

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Npc1b	NP_608417.2	2A060601	24..1220	CDD:273337	191/1037 (18%)
ptr-21	NP_490751.1	Patched	83..863	CDD:308203	188/1006 (19%)