Protein Alignment Npc1b and ptr-13

DIOPT Version :10

• Sequence 1: NP_608417.2
• Gene: Npc1b / 33072
• FlyBaseID: FBgn0261675
• Length: 1254
• Species: Drosophila melanogaster
• Sequence 2: NP_496392.2
• Gene: ptr-13 / 191748
• WormBaseID: WBGene00004227
• Length: 851
• Species: Caenorhabditis elegans
• Alignment Length: 822
• Identity: 172/822 - (20%)
• Similarity: 327/822 - (39%)
• Gaps: 172/822 - (20%)

  Fly   457 QSVYGY---FQHDMDRFENSYVDSNNYTINYLNQLEDC-------LRVPMMEDCFG--------T 503
            |.|:.|   ::.:..||::...:..||..||..:|...       |..|:.| .||        .
 Worm   122 QFVWNYTTQYKQETIRFKDLSSEDINYVFNYYRKLLAIEWMPGVNLSYPLAE-AFGHPFYLGNQF 185

  Fly   504 FG---------GPIEPG--IAVGGMPKVAVGEDPDYMLATGLVLTFLGRNYNDESKLEPNMKWE- 556
            ||         |||:..  :|:..|.|....|....:.|..|.:      :...::...|::::
 Worm   186 FGVNNGQASKAGPIKTAKFVALWYMSKAETFEQKQKLQAVQLGI------FKKSAERPNNLQFDF 244

  Fly   557 KLFVDFLRDYKSDRLDIAYMAERSIQDAIVELSEGEVSTVVISYV---VMFVYVAIALGHIRSCR 618
            ::|.|                    |.|..|:..|.::||.:.::   :|..::|.....:...
 Worm   245 EMFGD--------------------QVANSEMLRGTLTTVKLFFIGGCLMVAFMACTFTELTIF- 288

  Fly   619 GFLRESRIMLAIGGIVIVLASVVCSLGFWGYLDVTTTMLAIEVIPFLVLAVGVDNIFIMVHTYQR 683
                 |:.||..|.|...||:........|::......:.. :.|||:|.:|||:.|::::.::|
 Worm   289 -----SKCMLIAGAIGSPLAATGACFAILGWVGHPFNSIMC-ITPFLILGIGVDDAFLLLNCWRR 347

  Fly   684 LDHSKFKTTHEA---IGEAIGQVGPSILQTAGSEMACFAIGCISDMPAVKTFAMYAAIAILLDFL 745
             :..|.|:..:|   :...|.::.||:..|:.:....|.:|.::..|.:.:|.:..|:||:||||
 Worm   348 -EEGKDKSAKQAENQLARVIREISPSMAITSLTNTMAFGVGFLAPTPQMSSFCLGTALAIVLDFL 411

  Fly   746 LQITAFVALMAIDEKRYLDGRLDMLCCVKSGGKKINDED--GDGVDRPKE--VGLLETLFKNFYS 806
            |:...||..|.:..|:    :.:::.        |.:|:  .:..::..|  .|....:....::
 Worm   412 LEFLIFVPCMVLFYKK----KPEIIA--------IENEEFANEKTEKRSETSTGKYSRINWKCFT 464

  Fly   807 PFLLSKPVKVSVLLIFTVITCLSLMVTPSIEKGLDQEMSMPKNSHVVKYFRYMVDLLAMGAPVYW 871
            ..|||.|.:|.|::::..|...|......:||..|...:.|.:|.       :||.||....:..
 Worm   465 NLLLSVPGRVLVIILYFSIFTASYFGVAKMEKTFDPSKTFPSDSK-------LVDSLASFTSIQV 522

  Fly   872 VLKPGLNY--SEPLQQNLICGGVECNNNSLSVQL-YTQAQYPEITSLARPASSWLDDYIDWLAIS 933
            ...| ||:  |.|..:|   .....|.|.:..:| :.:..|.::.|     .:...||:.:|..|
 Worm   523 EYSP-LNFLSSVPDLKN---DTDVANFNEMLHKLEFREECYGDVGS-----HNMYRDYVQFLNYS 578

  Fly   934 DCCKYNVTTGGFCSSNSKSEDCLPCERGFTENGLRPDAETFNKYIPYFLFDLPDAECAKAGRASY 998
                 |:|        .||.:.|               |.|.|                 || ..
 Worm   579 -----NIT--------DKSYNHL---------------EKFLK-----------------GR-GM 597

  Fly   999 ADAVIYTIDDVGMSTVQDSYFMQYSTTSTTSEEFYSQLREVRRISGEINAMFKENNVDAEIFAYC 1063
            ||.........|..|:.|  .:.:.......|::..:...|.: :.:|...:.:.|:  .:|.|
 Worm   598 ADVGTIKYHKEGNDTIID--MINFVVVCQGREKWAERAVNVEK-TRQILVDYSDYNI--TLFDY- 656

  Fly  1064 VFYIYYEQYLTIWGDAMFSLGMSLVAIFLVTLLITGLDITSTFIVLFMVICILINMLGMMWAWSI 1128
             ....|:..:|:.|:.:.||.::...:.:...:|....:..| |.....:.|...::|.:..|..
 Worm   657 -DGTIYDLIITVKGELVKSLAITFTCMTIACFVIMPSFVAPT-IASVATVSISFCLIGFLSIWGQ 719

  Fly  1129 NLNAISLVNLVVCVGIGVEFVAHIVRSFKRAE----GTAQERARHSLNVTGSSVL--SGITLTKF 1187
            ||:.::::::::.:|..|::.||:...:..|.    |:..|.....|...|..|:  |..||...
 Worm   720 NLDPVTMIDVIMAIGFSVDYSAHVCYHYYCAREQHLGSKHEVITSVLQAVGRPVVEASLTTLLCM 784

  Fly  1188 AGIVVLGFSNSQIFQVFYFRMYLGIVL-IGAAHGLILLPVLL 1228
            |.:.|:     .::.:..|...:.:|. .|..|||..|||:|
 Worm   785 APLFVV-----PVYMIQSFAKTVTLVTSFGLLHGLFFLPVVL 821

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Npc1b	NP_608417.2	2A060601	24..1220	CDD:273337	165/812 (20%)
ptr-13	NP_496392.2	Patched	112..821	CDD:308203	171/820 (21%)