| Sequence 1: | NP_608417.2 | Gene: | Npc1b / 33072 | FlyBaseID: | FBgn0261675 | Length: | 1254 | Species: | Drosophila melanogaster |
|---|---|---|---|---|---|---|---|---|---|
| Sequence 2: | NP_508771.1 | Gene: | ncr-1 / 180719 | WormBaseID: | WBGene00003561 | Length: | 1383 | Species: | Caenorhabditis elegans |
| Alignment Length: | 1372 | Identity: | 353/1372 - (25%) |
|---|---|---|---|
| Similarity: | 608/1372 - (44%) | Gaps: | 243/1372 - (17%) |
- Green bases have known domain annotations that are detailed below.
|
Fly 23 GCIWYG--QSHMIGAHW-VNKGDTNPARPLNSPTSEAIFAKR---CPMLYKEYKGESGEDELSLC 81
Fly 82 CDAAQIETMESGLSQADGVFSRCPTCTRNMALTVCAMTCAKNHTLFLT-----------AYNDTN 135
Fly 136 DAGVDYVKYIDYRLTDDTVSKIYNSCIGIQHTQTGRPAMDLGCGSYNAKTCNYRRWYEFMGDVSG 200
Fly 201 DY-VPFQINYKWSEDAE--EGSNEIYLDLSPLKCGESYEDSY-ACACIDC--EESCPLTDAPTGP 259
Fly 260 DELWKIAG----LYGVTFILALIIACALSFFIFWGAFGKTSAPSVCMPTLFGEF----------- 309
Fly 310 ----------------FYHGF-----RIWGTFCAKHP-------VIVLALCSWAIAGLSFGIRYM 346
Fly 347 TITTDPVELWAGEESQTRIEKDYFDQHFGPFYRTNQMFVKAVNQTYFTHE--TSNGVLNFGPAFE 409
Fly 410 YNFLKEVFELQDSIMKLGMADNEG----LDKICYAPVLMAGETPTVDRCAIQSVYGYFQ------ 464
Fly 465 -----------HDMDRFENSYVDSNNYTINYLNQLEDCLRVPMME------DCFGTFGGPIEPGI 512
Fly 513 AVGGMPKVAVGEDPDYMLATGLVLTFLGRNYNDESKLEPNMK----WEKLFVDFLRDY--KSDRL 571
Fly 572 DIAYMAERSIQDAIVELSEGEVSTVVISYVVMFVYVAIALGHIRSCR----GFLRESRIMLAIGG 632
Fly 633 IVIVLASVVCSLGFWGYLDVTTTMLAIEVIPFLVLAVGVDNIFIMVHTY--QRLDHSKFKTTH-- 693
Fly 694 EAIGEAIGQVGPSILQTAGSEMAC---FAIGCISDMPAVKTFAMYAAIAILLDFLLQITAFVALM 755
Fly 756 AIDEKRYLDGR---------LDMLCCVKSGGKKINDEDGDGVDRPKEVGLLETLFKNFY----SP 807
Fly 808 FLLSKPVKVSVLLIFTVITCLSLMVTPSIEKGLDQEMSMPKNSHVVKYFRYMVDLLAMGAPVYWV 872
Fly 873 LKPGLNYSEPLQQNLICGGVECNNNSLSVQLYTQAQYPEITSLARPASSWLDDYIDWLA-ISDCC 936
Fly 937 K-YNVTTGGFCSSN-SKS----EDCLPC------ERGFTENGL---RPDAETFNKYIPYFLFDLP 986
Fly 987 DAECAKAGRASYADAVIYTIDDVGMSTVQDSYFMQY--STTSTTSEEFYSQLREVRRISGEINAM 1049
Fly 1050 FKENNVD--AEIFAYCVFYIYYEQYLTIWGDAMFSLGMSLVAIFLVTLLITGLDITSTFIVLFMV 1112
Fly 1113 ICILINMLGMMWAWSINLNAISLVNLVVCVGIGVEFVAHIVRSFK-RAEGTAQERARHSLNVTGS 1176
Fly 1177 SVLSGITLTKFAGIVVLGFSNSQIFQVFYFRMYLGIVLIGAAHGLILLPVLLSLLGPPQKLARSS 1241
Fly 1242 GAEPTAS 1248 |
| Gene | Sequence | Domain | Region | External ID | Identity |
|---|---|---|---|---|---|
| Npc1b | NP_608417.2 | 2A060601 | 24..1220 | CDD:273337 | 341/1341 (25%) |
| NPC1_N | 24..270 | CDD:293023 | 67/272 (25%) | ||
| nitrilase | <265..>331 | CDD:299711 | 19/108 (18%) | ||
| Sterol-sensing | 623..775 | CDD:289145 | 50/167 (30%) | ||
| ncr-1 | NP_508771.1 | 2A060601 | 22..1284 | CDD:273337 | 348/1353 (26%) |
| NPC1_N | 22..251 | CDD:293023 | 59/242 (24%) | ||
| MMPL | 660..814 | CDD:304422 | 49/156 (31%) |
| Tool | Simple Score | Weighted Score | Original Tool Information | |||
|---|---|---|---|---|---|---|
| BLAST Result | Score | Score Type | Cluster ID | |||
| Compara | 0 | 0.000 | Not matched by this tool. | |||
| Domainoid | 1 | 1.000 | 111 | 1.000 | Domainoid score | I3908 |
| eggNOG | 1 | 0.900 | - | - | E1_KOG1933 | |
| Hieranoid | 1 | 1.000 | - | - | ||
| Homologene | 0 | 0.000 | Not matched by this tool. | |||
| Inparanoid | 1 | 1.050 | 522 | 1.000 | Inparanoid score | I680 |
| Isobase | 1 | 0.950 | - | 0 | Normalized mean entropy | S1850 |
| OMA | 1 | 1.010 | - | - | QHG55095 | |
| OrthoDB | 1 | 1.010 | - | - | D31089at33208 | |
| OrthoFinder | 1 | 1.000 | - | - | FOG0001659 | |
| OrthoInspector | 1 | 1.000 | - | - | mtm4779 | |
| orthoMCL | 1 | 0.900 | - | - | OOG6_101370 | |
| Panther | 1 | 1.100 | - | - | O | PTHR45727 |
| Phylome | 1 | 0.910 | - | - | ||
| RoundUp | 0 | 0.000 | Not matched by this tool. | |||
| SonicParanoid | 1 | 1.000 | - | - | X943 | |
| SwiftOrtho | 1 | 1.000 | - | - | ||
| TreeFam | 1 | 0.960 | - | - | ||
| 15 | 14.790 | |||||