Protein Alignment Npc1b and ptr-6

DIOPT Version :10

• Sequence 1: NP_608417.2
• Gene: Npc1b / 33072
• FlyBaseID: FBgn0261675
• Length: 1254
• Species: Drosophila melanogaster
• Sequence 2: NP_494986.2
• Gene: ptr-6 / 173898
• WormBaseID: WBGene00004221
• Length: 982
• Species: Caenorhabditis elegans
• Alignment Length: 1057
• Identity: 228/1057 - (21%)
• Similarity: 423/1057 - (40%)
• Gaps: 243/1057 - (22%)

  Fly   310 FYHGFRIWGTFCAKHPVIVLALCSWAIAGLSFGIRYMTITT-----DPVELWAGEESQTRIE--- 366
            :|:.|.|       .|||:.|:||...    :.|:.:|:..     .||...:.:|.|...|
 Worm    27 YYYVFLI-------APVILTAICSCGF----YWIKELTLLDARKLYTPVSAPSWKEEQVFSELWP 80

  Fly   367 -KDYFDQHFGP--FYRTNQMFVKAVNQTYFTHETSNGVLNFGPAFEYNFLKEVFELQDSIM---- 424
             |.|   .|.|  .::.|:.....|:...:.:.|...:|      |.::|.::.::::.::
 Worm    81 VKSY---EFLPERTFQWNRYLYLVVHGRPYENGTYPNIL------EGSYLNDIAKIEEELVTNVS 136

  Fly   425 ---KLGMADNEGLDKICYAPVLMAGETPTVDRCAIQSVYGYFQHDMDRFENSYVDSNNYTINY-- 484
               :..:.||         |.||.                  :..::  |....::.|.||.:
 Worm   137 FPREAALEDN---------PALMR------------------KRHLN--ETEIEENRNITITFKD 172

  Fly   485 --LNQLEDCLRVPMMEDCFG------------TF------GGPIEPGIAVGGM---PKVAVGEDP 526
              :|...||.|...:.:...            ||      |.||.....:||:   |...:
 Worm   173 VCMNWYGDCYREKNVIELLKRRHELNKRGISVTFPQVNQEGTPIYIAFVIGGVDTYPNDTI---- 233

  Fly   527 DYMLATGLVLTFLGRNYNDESKLEPNMKWEKLFVDFLRDYKSDRLDI-AYMAERSIQDAIVELSE 590
            .|..|..| ..||  .::||.:.:....||.....|:|:..:|...| .::....|.|..:..:.
 Worm   234 KYARAMRL-WYFL--KFDDEEQEQLAKFWEDTAEKFVRETYADHPTIQCHIKHSRIVDQGLTRNA 295

  Fly   591 GEVS---TVVISYVVMFVYVAIALGHIRSCRG------FLRESRIMLAIGGIVIVLASVVCSLG- 645
            ..:.   .|.|:.:|:|........:.|....      :|| |:.|||:||::..:.:::..:|
 Worm   296 NRLKPYFNVTIAVLVLFTAFYSVKWYFRMDHSWPLHIDWLR-SKPMLALGGVLSSVLAILSGIGL 359

  Fly   646 --FWGYLDVTTTMLAIEVIPFLVLAVGVDNIFIMVHTYQRLDHSKF-----KTTHEAIGEAIGQV 703
              ::|......|::|    |||||::|||::||.|..:...: .|:     |...:.:.||:.:.
 Worm   360 LLWFGMFFAEITLIA----PFLVLSIGVDDMFIAVAAWHNTE-MKYPGRSPKVMKKRMIEAMSES 419

  Fly   704 GPSILQTAGSEMACFAIGCISDMPAVKTFAMYAAIAILLDFLLQITAFVALMAIDEKRYLDGRLD 768
            ..:|..|:.:::..|..|.|:|:.||:.|....|..:...||.|||.|.|||.|..|..:.||..
 Worm   420 AVAIFITSFTDVLSFGAGTITDIIAVQGFCAMTAACMFFTFLYQITFFAALMVISAKAQMSGRNS 484

  Fly   769 MLCCVKSGG---------------KKI-----------------ND------EDGDGVDR----- 790
            .:.|:.:|.               ||.                 ||      |:.:..::
 Worm   485 CMPCITAGDIYTIEDGSLQPNLKKKKSKSRKDAKAEKEKKDEAKNDKNMEIEENAENAEKSSYDS 549

  Fly   791 ---PKEV-------GLLETLFKNFYSPFLLSKPVKVSVLLIFTVITCLSLMVTPSIEKGLDQEMS 845
               |.::       |.:...|:::|.|:||:...|:.:.:.|.:...:|:.....:|:|||.:..
 Worm   550 SPDPSQIHIPVKSRGAMGHFFRDYYVPWLLNWKTKLFMFVTFIIYLGISVYGICVMEQGLDYDKL 614

  Fly   846 MPKNSHVVKYFRYMVDLLAMGAPVYWVLKPGLNYSEPLQQNLICGGVECNNNSLSVQLYTQAQYP 910
            :..:..:|:..:..::|...|..:           |...||  |..:....:...::|..| ::.
 Worm   615 LLHSDPLVEALKREIELFHGGDQI-----------EIAIQN--CPNITIAESRDRIELVAQ-EFE 665

  Fly   911 EIT-SL-ARPASSWLDDYIDWLAISDCCKYNVTTGGFCSSNSKSEDCLPCERGFTENGLRPDAET 973
            .|: || .:..|.|:.:|         .||:..||.:.:.|.:|...          |:...::.
 Worm   666 NISYSLGGKGTSFWMREY---------KKYSNLTGSYLNDNRESWIV----------GVYEWSQL 711

  Fly   974 FNKYIPYFLFDLPDAECAKAGRASYADAVIYTIDDVGMSTVQDSYFMQYSTTSTTSEEFYSQLRE 1038
            |..|      .|...:...|..:.|        |.:.:.:.:....:...:|.|.......:||.
 Worm   712 FAFY------KLWSQDFVWANESDY--------DTLELKSYRFRIGVHRLSTPTDLVLITEELRG 762

  Fly  1039 VRRISGEINAMFKENNVDAEIFAYCVFYIYYEQYLTIWGDAMFSLGMSLVAIFLVTLLITGLDIT 1103
            |           .:.:.|..|..|.......:|...|....:.:..:::..:|.|.|:.....|.
 Worm   763 V-----------ADRHPDLNIVTYQQSRAIADQLNVILSSTITNDTLAMFCMFCVALIFIPNPIC 816

  Fly  1104 STFIVLFMVICILINMLGMMWAWSINLNAISLVNLVVCVGIGVEFVAHIVRSFKRAEG--TAQER 1166
            :.||. |.::.|.|.::|.:..||:.|:.||::.:::.:|..:||.|||...|...:.  :|.:|
 Worm   817 ALFIT-FAMVTIDIGVIGFLSLWSVKLDPISMITIIMSIGFSIEFSAHITHGFVSNDSNLSAFDR 880

  Fly  1167 ARHSLNVTGSSVLSGITLTKFAGIVVLGFSNSQIFQVFYFRMYLGIVLIGAAHGLILLPVLLSLL 1231
            ...::......|:.| :|:...|:.||.|.:|.:..||:..:.| :::|||.|.|:|||:|||:.
 Worm   881 CVDAMEKLAWPVVHG-SLSTILGVFVLAFIDSYMVLVFFKTISL-VLIIGAWHALMLLPILLSMC 943

  Fly  1232 GPPQKLARSSGAEPTAS 1248
            .|  .:.|.|.|...||
 Worm   944 IP--VIERLSDASKKAS 958

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Npc1b	NP_608417.2	2A060601	24..1220	CDD:273337	214/1027 (21%)
ptr-6	NP_494986.2	Patched	52..945	CDD:308203	212/1004 (21%)