Protein Alignment Npc1b and ptr-3

DIOPT Version :10

• Sequence 1: NP_608417.2
• Gene: Npc1b / 33072
• FlyBaseID: FBgn0261675
• Length: 1254
• Species: Drosophila melanogaster
• Sequence 2: NP_493718.2
• Gene: ptr-3 / 173426
• WormBaseID: WBGene00004218
• Length: 927
• Species: Caenorhabditis elegans
• Alignment Length: 1042
• Identity: 229/1042 - (21%)
• Similarity: 392/1042 - (37%)
• Gaps: 263/1042 - (25%)

  Fly   328 VLALCSWA--------IAGLSFGIRYMTITTDPVELWA-GEESQTRIEK--DYFDQHFGP--FYR 379
            |:..|.|.        ...||..|.:..:..|..:... |..|:..:||  .:|:.|..|  .|.
 Worm    30 VICYCPWTCIILTIMLTLVLSLKIPFTRMQNDISDFTPFGARSRVELEKYRKFFNNHGEPKAIYA 94

  Fly   380 -------TNQMFVKAVNQTY---------FTHETSNGVLNFGPAFEYNFLKEVFELQDSIMKLGM 428
                   .|.:.:..:|.|.         |..:||.|..||.            |.......|
 Worm    95 FITSKVGDNMLGISQLNDTVHVLDTISRDFYLKTSQGPKNFE------------EYCSGFCLL-- 145

  Fly   429 ADNEGLDKICYAPVLMAGETPT----VD-RCAIQSVYGYFQHDMDRFENSYVDSNNYTINYLNQL 488
              ||.: |..|:.:|::|:..|    :| ...|.:|.|         ...|:|.|.:.:...
 Worm   146 --NEPV-KHFYSGMLISGQHGTDFSHLDLGYPITTVLG---------TKLYMDPNFFGVKVT--- 195

  Fly   489 EDCLRVPMMEDCFGTFGGPIEPGIAVGGMPKVA--VGEDPDYMLATGLVLTFLGRNYNDESKLEP 551
                          |....:| .||.|......  ..::|:.:....||:........||...|.
 Worm   196 --------------TSNNKVE-SIADGNTKLFGDHTKQEPNNIREVSLVVLQFRSELGDEVTPED 245

  Fly   552 NMKWEKLFVDFLRD-YKSDRLDIAYMAERSIQDAIVELSEGEVSTVVISYVVMFVYVAIALGHIR 615
            ...:|...:|::.| |:|:.:::..:.:..|.:.||......:..:||.:.:|.|:.:|......
 Worm   246 LRNYEHQILDYIHDEYQSEHINVYILTDSYITEEIVRAGLTLLPFLVIGFTIMAVFSSITFVVSA 310

  Fly   616 SCRGFLRESRIMLAIGGIVIVLASVVCSLG--------FWGYLDVTTTMLAIEVIPFLVLAVGVD 672
            .....|...:.:||:...|....:...|||        |...|.||         ||||||:|||
 Worm   311 YYTKQLNFYKPILAVMACVCPFMACGASLGAMFFIGFRFGSILCVT---------PFLVLAIGVD 366

  Fly   673 NIFIMVHTYQRL-----DHSKFKTTH----EAIGEAIGQVGPSILQTAGSEMACFAIGCISDMPA 728
            :.::|.:.:||:     .|::|::.:    ..|.|...:.||||..|..:....|.||..:....
 Worm   367 DSYLMANAWQRITCHRRKHARFESVNVELKNRITEMFIETGPSITITTITNALAFGIGATTPAAE 431

  Fly   729 VKTFAMYAAIAILLDFLLQITAFVALMAIDEKRYLDGRLDMLCCVKS-----GGKKINDEDGDGV 788
            ::.|::..|:|::.||:..||.:.||||:      .||.::...:|:     ..:..::....|.
 Worm   432 IQLFSIGNALAVITDFVFTITFYGALMAV------VGRYEIEQELKTQKPLPESESPSETSSTGS 490

  Fly   789 DRPKEVGLLETLFKNFYS---PFLLSKPVKVSVLLIFTVITCLSLMVTPSIEKGLDQ-------- 842
            .|..|  |.:..|:...:   .||.:..|...||.:..|...:.::.|.:|:..|..
 Worm   491 MRSSE--LDDCKFRRMIANVCKFLTNTWVCSVVLGLLAVYWYICIVGTVNIKSELSPNKLFLAES 553

  Fly   843 ---EMSMPKNSHVVKYFRYMVDLLAMGAPVYWVL--KPGLNYSEPLQQNLICGGVECNNNSLSVQ 902
               |:...:.||::.|:           ...|||  .||                :.||.:...:
 Worm   554 NIVEIFKQRKSHIIPYY-----------SACWVLVENPG----------------DINNPNQRAK 591

  Fly   903 LYTQAQYPEITSLARPASS-------WLDDYIDWLAISDCCKYNVTTGGFCSSNSKSEDCLPCER 960
            |....:..|    |.|:::       ||.||.|:|..|:                  |..||.|.
 Worm   592 LEELIESFE----ALPSANGRYSTKFWLRDYEDFLKQSE------------------EIDLPMEE 634

  Fly   961 --------GFTENGLR--PDAETFNK--YIPYFLFDLPDAECAKAGRASYADAVIYTIDDVGMST 1013
                    .||.||.:  ..::.|.:  .:..|| :.|:....|.            ...|..||
 Worm   635 EEDEELAIQFTVNGSQVVTPSQPFGQGNELRQFL-EWPEFSFWKG------------FIQVNEST 686

  Fly  1014 VQDSYFMQYSTTSTTSEEFY------SQLREVRRISGEINAMFKENNVDAEIFAYCVFYIYYEQY 1072
            .|.|.|:  .||:....:..      ..|.|.|.::.:  ..||..||..           ||:
 Worm   687 YQMSKFL--VTTAYHGSDLVDWSNRAKLLNEWRSVADQ--DKFKSLNVTV-----------YEE- 735

  Fly  1073 LTIWGDAMF---SLGMSLVAI------FLVTLLITGLDIT---STFIVLFMVICILINMLGMMWA 1125
                 ||.|   ...||.|||      |....|:..|.|:   :.|:..|.::...:.:.|:|..
 Worm   736 -----DAKFLDLIETMSPVAIQSALWTFASMFLVAALFISHPPTLFVATFSILSTSLGVFGIMSW 795

  Fly  1126 WSINLNAISLVNLVVCVGIGVEFVAHIVRSF-KRAEGTAQERARHSLNV--TGSSVLSGITLTKF 1187
            |..:|:.|.:...|:.:|..|:..:|:...| :.|:.|:..|.|..:.:  .|..:......|..
 Worm   796 WGADLDPIMMSATVMSIGFSVDIPSHVSYHFYQTAKDTSDIRRRLQMTIEAVGFPIFEASLSTSL 860

  Fly  1188 AGIVVLGFSNSQIFQVFYFRMYLGIVLIGAAHGLILLPVLLSLLGP-PQKLARSSGAEPTASITI 1251
            . ::.|.|.:..:.|:|...|.| :|:||..||::::||:.:||.. |:|| :.......:::|:
 Worm   861 C-VMSLFFVDLNMAQIFAKCMLL-VVVIGMVHGMLVMPVIFALLDTVPRKL-KPRKQHLASTVTV 922

  Fly  1252 TT 1253
            .|
 Worm   923 VT 924

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Npc1b	NP_608417.2	2A060601	24..1220	CDD:273337	218/1006 (22%)
ptr-3	NP_493718.2	Patched	48..904	CDD:308203	221/1001 (22%)