Protein Alignment Npc1b and ptr-23

DIOPT Version :10

• Sequence 1: NP_608417.2
• Gene: Npc1b / 33072
• FlyBaseID: FBgn0261675
• Length: 1254
• Species: Drosophila melanogaster
• Sequence 2: NP_493603.1
• Gene: ptr-23 / 173362
• WormBaseID: WBGene00004237
• Length: 983
• Species: Caenorhabditis elegans
• Alignment Length: 1066
• Identity: 212/1066 - (19%)
• Similarity: 380/1066 - (35%)
• Gaps: 292/1066 - (27%)

  Fly   314 FRIWGTFCAKHPVIVLALCSWAIAGLSFGIRYMTITTDPVELWAGEESQTRIEKDYFDQHFGPFY 378
            ||.||...|||..:.:.:|   :...:..|..:.:|....::........|.:.:|.:  :..|:
 Worm    40 FRKWGFLIAKHAWLAILIC---LIISTLAIVKILLTKQANDITGYTPYGARAKDEYLE--YQKFF 99

  Fly   379 RTNQMFVKA-----------VNQTYFTHETSNGVLNFGPAFEYNFLKEVFELQDSIMKLGMADNE 432
            .::.:.:.|           :::..:..||.. ||||.       |..: .:.|||.......|:
 Worm   100 SSSGLPIAAYLYIVAKDEGSMSRPDYLDETIQ-VLNFA-------LNNI-TMYDSISGKSETFNQ 155

  Fly   433 GLDKICYA-----------PVLMAGETPTVDRCAIQSVYGYFQHDMDRFENSY-VDSNNYTINYL 485
            .....|..           .:|..||..:  |..||    |...||  |...: :..|.:.:...
 Worm   156 FCQSFCQINEPVRQFYNGYQILSDGEQNS--RIKIQ----YPVSDM--FGRQFSLQPNFFGVELF 212

  Fly   486 NQLEDCLRVPMMEDCFGTFGGPIEPGIAVGGMPKVAVGEDPDYMLATGLVLTFLGRNYNDESKLE 550
            :|.:|..:  :::...|      :|.|.:.....|    ||...:.....:..:...:..|.|
 Worm   213 DQPDDAAK--LLDSADG------DPVIELNATKLV----DPVSRITNVKSVKMITLQFRAEHK-- 263

  Fly   551 PN------MKWEKLFVD-FLRDYKSDRLDIAYMAERSIQDAIVELSEGEVSTVVISYVVMFVYVA 608
            |.      .|||...|| |.:.|.|.||.|...::..:::   |:..|.:  ::|.|:|    |.
 Worm   264 PGWTEAQVKKWEMSLVDIFEKRYNSKRLKIYAYSQSYVEE---EMVRGGI--IMIPYLV----VG 319

  Fly   609 IALGHIRSCRGFLRESRIMLAIGGIVIVLASVVCSLGFWGYLDVTTTMLAIE------------V 661
            .|:..:.||...:..:..|....|..|:||.:.|...    |....|.||:.            |
 Worm   320 FAIMCLCSCVLVMIRALYMHQENGYKIILAIMACLTP----LLACATALALMFLCGVRFASILCV 380

  Fly   662 IPFLVLAVGVDNIFIMVHTYQRLDHSKFKTTH--EAIG----EAIGQVGPSILQTAGSEMACFAI 720
            ||||||::|||:.::|:|.:||:.....:|..  :::|    |.:.:|||:||.:..:.|...|:
 Worm   381 IPFLVLSIGVDSSYLMIHEWQRVTKHMRETPRKKDSVGHRMSEVMAEVGPAILISCLTNMFADAV 445

  Fly   721 GCISDMPAVKTFAMYAAIAILLDFLLQITAFVALMAIDEKRYLDGRLDMLCCVKSGGKKINDEDG 785
            |..:..|.:........:::...|:.|:|.:..||:|                 .||.:..   .
 Worm   446 GSFTSSPEITLLCTGNMLSMWFAFIYQMTFYAGLMSI-----------------VGGYEFG---S 490

  Fly   786 DGVDRPK-EVGLLE----------------TLFKNFYSPF----------LLSKP-VKVSVLLIF 822
            |.:|:.: |:.:.|                :.|.....|.          |::.| |.|||.|::
 Worm   491 DEIDKNRMEINIAENRVNIARHHRPLTRQPSKFHEATQPIISDSLQKYTHLMTTPLVFVSVCLVY 555

  Fly   823 TVITCLSLMVTPSIEKGLDQEMSMPKNSHVVKY----FRYMVDLLAMGAPVYWVLKPGLNYSEPL 883
            ......|:.....:...|..:.....:|.:::.    .:|.|.:.:| |.|: |..||
 Worm   556 IAYLAFSVYGITQLNINLTAQKLFALDSPLLELDDLRIKYQVPVYSM-ATVF-VNTPG------- 611

  Fly   884 QQNLICGGVECNNNSLSVQLYTQAQYPEITSLARPASS----WLDDYIDW------LAISDCCKY 938
                              :|...|:...:....|...|    |.:   .|      ..:.|   |
 Worm   612 ------------------KLENPARLKRLNEFVREMESINGTWGE---GWGELGTKYFVRD---Y 652

  Fly   939 NVTTGGFCSSNSKSEDCLPCERGFTENGLRPDAETFNKYIPYFLFDLPDAECAKAGRASYADAVI 1003
            :|....|.|.:...||.:..::..|.:.                                .|.:.
 Worm   653 DVFQQSFGSEDEDDEDFMDDDKPVTVHS--------------------------------DDKMT 685

  Fly  1004 YTIDDVGMSTVQDSYFMQYSTTSTTSEEFYSQLREVRRISGEINAMFKENNVDAEIFAYCVFYI- 1067
            |..|::       .||:::     ...:|:....::|..:         |:.|.|......|:.
 Worm   686 YREDEL-------KYFLKW-----PEYDFWQGFVKLRNAT---------NSTDPEAEELDRFFFT 729

  Fly  1068 --YYEQYLTIWG-------------DAMFSLGMSL-----VAIFLVTLLITGL--DITSTFIVLF 1110
              |:...||||.             |.....|.|:     |.:.|:..:.|..  .|..|.:.:.
 Worm   730 TGYHGDNLTIWTQRGEMLRAWRQVVDKYPDFGASVFHEDGVYLDLIDNMPTDTWQSILGTLVCMA 794

  Fly  1111 MVICILIN------------------MLGMMWAWSINLNAISLVNLVVCVGIGVEFVAHIVRSFK 1157
            ||..:.:|                  :||.:..|.::|:.|::..:::.:|..|:..||:...:.
 Worm   795 MVCFVFLNNWFTVAIASLSVLSICAGILGFLSWWKVDLDPITMAAMIISIGFSVDIPAHVSYHYY 859

  Fly  1158 RA---EGTAQERARHSLNVTGSSVLSGI--TLTKFAGIVVLGFSNSQIFQVFYFRMYLGIVLIGA 1217
            :|   ||.....:....|...|.....:  .|:....:..|.|.|..:.:||...|.|.:||..
 Worm   860 QASIQEGPMSPPSSRLANCLSSVAFPALQAALSTILCVCSLLFVNLYMAEVFVKTMVLCVVLCN- 923

  Fly  1218 AHGLILLPVLLSLLGPPQKLARSSGA 1243
            .|||:.||.:|.||...:...|..||
 Worm   924 LHGLVFLPAILILLDSIRWACRPKGA 949

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Npc1b	NP_608417.2	2A060601	24..1220	CDD:273337	201/1041 (19%)
ptr-23	NP_493603.1	Patched	68..938	CDD:308203	199/1022 (19%)