Protein Alignment Npc1b and ptr-12

DIOPT Version :10

• Sequence 1: NP_608417.2
• Gene: Npc1b / 33072
• FlyBaseID: FBgn0261675
• Length: 1254
• Species: Drosophila melanogaster
• Sequence 2: NP_001021559.2
• Gene: ptr-12 / 171816
• WormBaseID: WBGene00004226
• Length: 901
• Species: Caenorhabditis elegans
• Alignment Length: 1028
• Identity: 207/1028 - (20%)
• Similarity: 367/1028 - (35%)
• Gaps: 250/1028 - (24%)

  Fly   314 FRIWGTFCAKHPVIVLALCSWAIAGLSFGIRYMTITTDPVELWAGEESQTRIEKDYFDQHFGPFY 378
            |..|..|.|.|.|.::.:|   :.....|...:..|.:..:: .|........:|.||
 Worm    30 FEKWSHFVADHAVALIVIC---VVLTLIGTFKVATTPNDNDI-TGYTPYGARARDEFD------- 83

  Fly   379 RTNQMFVKAVNQTYFTHETSNGVLNF--------GPAFEYNFLKEVFELQDSI---MKLGMADN- 431
                     |...:|.| ..||:..|        ......:.|:|...|:|.:   ..:..||.
 Worm    84 ---------VMTDFFAH-NGNGIAMFVLILPTRHESVLHPDVLREALRLEDILSTNFSMLSADGK 138

  Fly   432 -EGLDKICYAPVLMAGETPTVDRCAIQSVYGYFQH----DMDRFENSYVDSNNYTINYLNQLEDC 491
             |...:.|            .:.|.|...:..|..    ::|..:|....|...::||
 Worm   139 PENYQEFC------------TNFCQINEPFVQFARSYLTELDNSKNGTDLSERISLNY------- 184

  Fly   492 LRVPMMEDCFGTFGGPIEPGIAVGGMPKVAVGEDPDYMLATGLVLTFLG-RNYNDESKLEPNMKW 555
                                      |..::     |.....:...|.| ...|:..|...|::.
 Worm   185 --------------------------PITSI-----YSRKMSIQPNFFGIEMMNETKKSITNIRS 218

  Fly   556 EKLFVDFLRDYKSD----------RLDIAYMAERSIQD---AIVELSEGEVSTVVIS-------- 599
            .||....||..:.:          .:.|....|:..:.   .::.||...|...|:.
 Worm   219 SKLIALQLRSERKEGWNSNGIKDFEMSITNYLEKEFESPEIRVLTLSTSYVEAEVVRAGMSLLPF 283

  Fly   600 YVVMFVYVAIALGHIRSCRGFLRE--------SRIMLAIGGIVIVL--------ASVVCSLGFWG 648
            .:|.||.:||    :.|...|...        .:..|||...:...        |...|.:.|..
 Worm   284 LIVGFVIMAI----VSSVTTFFSAVYMQQVSIHKFSLAIAACICPFMACGTALGALFFCGVRFGS 344

  Fly   649 YLDVTTTMLAIEVIPFLVLAVGVDNIFIMVHTYQRL--DHSKFKTTHEAIGEAIGQV----GPSI 707
            .|.||         ||||||:|||:.::|:|::||:  :..|....:::.|..:.:|    ||:|
 Worm   345 ILCVT---------PFLVLAIGVDDAYLMIHSWQRVTAERRKHPVANDSPGSRLSEVLVDTGPAI 400

  Fly   708 LQTAGSEMACFAIGCISDMPAVKTFAMYAAIAILLDFLLQITAFVALMAI---------DEKRYL 763
            |.:|.:.:.....||.:..|.:..........|..|||.|||.:.|:|.:         ::||::
 Worm   401 LISALTNIFADVAGCFTSSPEISLLGYGNMACIFCDFLYQITFYSAIMTLTGYFEMKDEEQKRHI 465

  Fly   764 -----DGRLDMLCCVKSGGKKINDEDGDGVDRPKEVGLLE---TLFKN-FYSPFLLSKPVKVSVL 819
                 ....|...|..|     :.|..|.:.:.:....||   :|..| |:..|::...:...|:
 Worm   466 KKIACGADSDDSSCTSS-----SVESFDVIVKRRVTSFLENYISLITNAFFQIFVVLVWIAFLVV 525

  Fly   820 LIFTVITCLSLMVTPS---IEKGLDQEMSMPKNSHVVKYFRYMVDLLAMGAPVYWVLKPG-LNYS 880
            .|:. ||.:::.::|.   :|....:||...:..:|:..| |:.::        :|.||| |...
 Worm   526 SIYG-ITIMNINLSPRKLFMEDSSLREMDDLRVKYVIPNF-YLANV--------FVRKPGDLTDG 580

  Fly   881 EPLQQ-NLICGGVECNNNSLSVQLYTQAQYPEITSLARPASSWLDDYIDWLAISDCCKYNVTTGG 944
            ..||: |.....:|..|.|..             ||.  .:.::.|::::.|.  ..:.....||
 Worm   581 ARLQRLNQFVEEMEHLNGSWG-------------SLG--TNYFVRDFVNFQAA--MVEEEEAEGG 628

  Fly   945 FCSSNSKSEDCLPCERGFTENGLRPDAETFNKYI--PYFLFDLPDAECAKAGRASYADAVIYTID 1007
                   .|:....:||    |:  |......::  |.:||        ..|...:..|
 Worm   629 -------EEEASIVKRG----GI--DVNNLPMFLEWPEYLF--------WKGFVQFHSA------ 666

  Fly  1008 DVGMSTVQDSYFMQYSTTSTTSEEFYSQ---LREVRRISGEINAMFKENNVDAEIFAYCVFYI-Y 1068
              ...||.|.:|:.::...|..:.:.::   |||.|.:..:.:|.|     ...:|:....|: .
 Worm   667 --ENRTVLDRFFITFAIHGTNLQSWPARGDALREWRNVVDKYSAEF-----GLSVFSDDGIYVDL 724

  Fly  1069 YEQYLT-IWGDAMFSLGMSLVAIFLVTLLITGLDITSTFIVLFMVICILINMLGMMWAWSINLNA 1132
            .|...| .|..|:.:|.......|:..     .|:.:..:...::..|:..:||::.....:|:.
 Worm   725 IENMPTDAWQSAVATLACMAFICFVFM-----YDVPTVMVATSIIASIMTGILGILSLTGTDLDP 784

  Fly  1133 ISLVNLVVCVGIGVEFVAHIVRSFKRAEGTAQERARHSLNVTGSSV-LSGITLTKFAGIVVLGFS 1196
            |.:..|::.:|..|:..|||  |:......:....||.|:.|.||| ...:..|....:.||...
 Worm   785 IVMSALIISIGFSVDIPAHI--SYHYHTSPSDNGIRHRLHKTLSSVGFPALQATVSTSLCVLSLK 847

  Fly  1197 NSQIFQVFYF-RMYLGIVLIGAAHGLILLPVLLSLLGPPQKLARSSGAEPTAS 1248
            .|.|:....| :..:..:::...|.|:|||.|.::......|.|.....|..|
 Worm   848 FSSIYMSCAFVKTMITCMILCVFHALVLLPCLFAIFHRIHSLFRVPKTSPIES 900

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Npc1b	NP_608417.2	2A060601	24..1220	CDD:273337	197/998 (20%)
ptr-12	NP_001021559.2	Patched	66..883	CDD:308203	194/970 (20%)