Protein Alignment Npc1b and LOC1281707

DIOPT Version :10

• Sequence 1: NP_608417.2
• Gene: Npc1b / 33072
• FlyBaseID: FBgn0261675
• Length: 1254
• Species: Drosophila melanogaster
• Sequence 2: XP_061500628.1
• Gene: LOC1281707 / 1281707
• VectorBaseID: AGAMI1_000587
• Length: 1000
• Species: Anopheles gambiae
• Alignment Length: 1100
• Identity: 244/1100 - (22%)
• Similarity: 423/1100 - (38%)
• Gaps: 315/1100 - (28%)

  Fly   298 PSV----CMPTL-------FGEFFYHGFRIWGTFCAKHPVIVLALCSWAIAGLSFGIRYMTITTD 351
            |:|    ||..|       .|:|||.    .|.:.|.:....:.||...:|..|.|.........
Mosquito    43 PNVDRLNCMGRLSYYVSMAIGKFFYR----LGYWIANNAWKTIGLCFLLVALCSVGFIRFHKEKS 103

  Fly   352 PVELWAGEESQTRIEKDYFDQHFGPFYRTNQMFVKA-------VNQTY---------FTHETSNG 400
            |::||....|:.:.:.::..:||....|...:.:.|       |.||.         ||...|.|
Mosquito   104 PMKLWIPVGSKFQHDTNWLIEHFKEGNRIETVMITAPDVLVPEVLQTIATITEEVEGFTFHNSEG 168

  Fly   401 VLNFGPAFEYNFLKEVFELQDSIMKLGMADNEGLDKICYAPVLMAGETPTVDRCAIQSVYGYFQH 465
                                   .:||..|      :|:...|:|..|..:.|..        :|
Mosquito   169 -----------------------QRLGWTD------VCHKVPLIAEYTADLSRRK--------RH 196

  Fly   466 DMDRFENSYV-----DSNNYTINYLNQLEDCLRVPMME----DCFGT------------------ 503
            ..|..|.|..     .|..:....:: :...|..||:|    .|:|:
Mosquito   197 AQDLEEPSVTTRRPKKSKPFFTPVID-VPSFLFCPMVERLELGCYGSSLLELWKYNRTTIAGLSK 260

  Fly   504 ---------------FGGPIEPGIAVGGMPKVAVGEDPDYMLATGLVLT--FLGRNYND-ESKLE 550
                           .|..:|....:|.:.:...|.    :::.|.::|  |:..|::: :|.:.
Mosquito   261 EDIVDKLNRTTISPMTGHTVEFAELLGDVKRDWSGR----IVSAGSLVTHWFVHVNFSEVDSDVS 321

  Fly   551 PN------------MKWEKLFVDFL----RDYKSDRLDIAYMAERSIQDAIVELSEGEVSTVVIS 599
            .|            |.||:.|:..:    ||..::..||.|.|.||..|...|....::..::..
Mosquito   322 GNAAGTEDWVTENAMLWEERFLQIVTKAKRDLSNNETDIYYAAGRSYGDISEESMFKDMDKLIYG 386

  Fly   600 YVVMFVYVAIALGHIRSCRGFLRESRIMLAIGGIV------IVLASVVCSLGFWGYLDVTTTMLA 658
            .:|||||:.:.|....     ..|.|::|...|::      :....:|.:||. .|..|.|:
Mosquito   387 GIVMFVYMQLVLSKFS-----WTEFRVILGSVGLMSVGMGFVAGCGIVAALGV-SYGPVHTS--- 442

  Fly   659 IEVIPFLVLAVGVDNIFIMVHTYQRLDHSK-FKTTHEAIGEAIGQVGPSILQTAGSEMACFAIGC 722
               :|||::.:|||::|:|:..|:::..:. .....|.:|..:...|.||..|:.:::..|.:|.
Mosquito   443 ---LPFLLMGLGVDDMFVMMACYRKVRKANPDLQLAERMGLMLQHAGASITVTSLTDIVAFIVGS 504

  Fly   723 ISDMPAVKTFAMYAAIAILLDFLLQITAFVALMAIDEKRYLDGRLDMLCCVKSGGKKINDEDGDG 787
            |:.:|::::|.:|||..:.:.|:..||.|||:..:||.|....|...|..|      ::||....
Mosquito   505 ITVIPSLQSFCIYAAAGVFMMFVFVITFFVAIFTLDELRIASRRNSFLLWV------VHDEKSTS 563

  Fly   788 VDRPKEVGLLETLFKNFYSPFLLSKPVKVSVLLIFTVITCLSLMVTPSIEKGLDQEMSMPK---- 848
            :  ..|..|:.......||.|||:...||.|:|...::|.:::.....:.:..|....:|:
Mosquito   564 L--WCEYNLMHRFINALYSKFLLTTVGKVLVILAVVLMTGVNVHNLLKLRQKFDPNWFIPEETYY 626

  Fly   849 NSHVVKYFRYMVD-----LLAMGAPVYWVLKPGLNYSEPLQQNLICGGVECNNNSLSVQLYTQAQ 908
            |..|||...:..:     :|..|         .|||:..| .|||         .::.:|..:
Mosquito   627 NQFVVKTHEHYPNAGYEAMLLFG---------HLNYTAEL-PNLI---------GITHRLENR-- 670

  Fly   909 YPEITSLARPASSWL-------------DDYIDWLAISDCCKYNVT-----TGGFCSSNSKSEDC 955
                |.:....|||:             |..:|.|:.:|..||...     .||....|.|....
Mosquito   671 ----TDILHSFSSWVTAFQDFVHTHYDKDIAVDALSEADFRKYLSKFLFSYEGGRYQMNIKFATK 731

  Fly   956 LPCER---GFTENGL----RPDAETFNKYIPYFLFDLPDAECAKAGRASYADAVIYTIDDVGMST 1013
            |.|.:   ..|...:    ||..|. .:|:|           ||           |.::||
Mosquito   732 LKCGQPAPNITVTTMDFKFRPFKER-EEYLP-----------AK-----------YAVEDV---- 769

  Fly  1014 VQDSYFMQYSTTSTTSEEFYSQLREV--RRISGEINAMFKENNVDAEIFAYCVFYIYYEQYLTIW 1076
                   ..|:..:|.:.:.:...::  ..::.||        :|.||:.
Mosquito   770 -------LASSNISTGDHYRTLWAKIFGNWVTDEI--------IDTEIYR--------------- 804

  Fly  1077 GDAMFSLGMSLVAI-FLVTLLITGLDITSTFIVLFMVICILINMLGMMWAWSINLNAISLVNLVV 1140
                 ::.::|:.: |...:||..|.|  .|.:...|:..|:|:.|:|..|.:.|:.:|.:.|.:
Mosquito   805 -----NISLALIGVMFCSVVLIVNLQI--CFWIFVCVLLTLVNVGGLMQVWGLTLDLVSCIALQL 862

  Fly  1141 CVGIGVEFVAHIVRSFKRAEGTAQERARHSLNVT-----------GSSVLSGITLTKFAGIVVLG 1194
            .||:.|::.|||..:|...  ...:|.|.||...           ||::||         :.:|.
Mosquito   863 AVGLCVDYAAHIGHTFLTI--NKGDRNRRSLETVLHIGAAVFYGGGSTILS---------LSILS 916

  Fly  1195 FSNSQIFQVFYFRMYLGIVLIGAAHGLILLPVLLSLLGPPQKLARSSGAEPTASITITTN 1254
            .|.:..::.| |:::|.::..|..||.|||||:|||:||    |..||:..:.: ||..|
Mosquito   917 GSQAYTYRTF-FKIFLLVIAYGLFHGTILLPVILSLIGP----APYSGSLNSLN-TINNN 970

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Npc1b	NP_608417.2	2A060601	24..1220	CDD:273337	226/1064 (21%)
LOC1281707	XP_061500628.1	None