DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Npc1b and npc1l1

DIOPT Version :9

Sequence 1:	NP_608417.2	Gene:	Npc1b / 33072	FlyBaseID:	FBgn0261675	Length:	1254	Species:	Drosophila melanogaster
Sequence 2:	XP_021334155.1	Gene:	npc1l1 / 100616532	ZFINID:	ZDB-GENE-110510-5	Length:	1411	Species:	Danio rerio

Alignment Length:	1254	Identity:	438/1254 - (34%)
Similarity:	672/1254 - (53%)	Gaps:	121/1254 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    62 CPMLYKEYKGESGEDELSLCCDAAQIETMESGLSQADGVFSRCPTCTRNMALTVCAMTCAKNHTL 126
            ||||      .:|:.:...||...|:..:::.||.:..|..|||:|..|.|...||.||:.:.:.
Zfish    77 CPML------ANGDGQTLACCSIRQLTALQNSLSLSKAVLIRCPSCAENFAYLHCATTCSPDQSQ 135

  Fly   127 FLTAYNDTN---------DAGVDYVKYIDYRLTDDTVSKIYNSCIGIQHTQTGRPAMDLGCGSYN 182
            .|......|         :|.|.|..||....:|.:    ::||..::...||..|:...||.|.
Zfish   136 ILKITKTANITQPTGIVKEAVVGYAAYISTNFSDAS----FDSCKNVRIPSTGGFAIATMCGRYG 196

  Fly   183 AKTCNYRRWYEFMGDVSGDYVPFQINYKWSEDAEEGSNEIYLDL-----SPLKCGE-SYEDSYAC 241
            |..|..:|||:|.||.|....|..|::|..:|:|  ::|:....     ..|||.| :.....||
Zfish   197 AALCTPQRWYDFQGDSSNGLAPLDIDFKLLQDSE--TSEVPAGAFAFAGQALKCNEVTPSGGEAC 259

  Fly   242 ACIDCEESCPLTDAPTGPDELWKIAGLYGVTFILALIIACALSFFIFW--------------GAF 292
            :|.||.:|||:...|....:.:.|..|.||..|...:.:|.|..|:.:              |..
Zfish   260 SCQDCLQSCPVVPEPPPLPKPFMIGNLNGVLVICLTVFSCFLFLFLCYVITECTTYYMKSRKGRK 324

  Fly   293 GKTSAPSVCMPTLF-----------------GEFFYHGFRIWGTFCAKHPVIVLALCSWAIAGLS 340
            ||::.........|                 .||....|:.|||..|::|.|||.:|...:...:
Zfish   325 GKSTKDQNANEIKFKISPKDVSCSDKASLATQEFLGSLFQSWGTLMARYPYIVLPVCLVIVLVFA 389

  Fly   341 FGIRYMTITTDPVELWAGEESQTRIEKDYFDQHFGPFYRTNQMFVKAVNQ-TYFTHETSNGVLNF 404
            .||:.:.:|||||:||:..||:...||.:.|.||.|||||||:.:.|..: ::|......|..||
Zfish   390 VGIKDIELTTDPVQLWSAPESRAMREKAFHDAHFDPFYRTNQLILTAPGRPSHFYDSLLFGKQNF 454

  Fly   405 GPAFEYNFLKEVFELQDSIMKLGMADNE-----GLDKICYAPVLMAGETPTVDRCAIQSVYGYFQ 464
            ......:.:.|:.:||.||..:....:|     .|..:|||| |..| .|::..||:.|:..|||
Zfish   455 SGIISKDLIIELLKLQQSIQAIEFWSDELNSTASLKDVCYAP-LNPG-NPSLTDCAVNSLPQYFQ 517

  Fly   465 HDMDRF-------------ENSYVDSNNYTINYLNQLEDCLRVPMMEDCFGTFGGPIEPGIAVGG 516
            :.:|..             |..:.|...|.:|.....:|...:.|  .|...:|||:.|.:||||
Zfish   518 NSIDNLNAKVNMTELGVTKEVDWRDHFIYCVNSPLSFKDITALGM--SCMSDYGGPVFPFLAVGG 580

  Fly   517 MPKVAVGEDPDYMLATGLVLTFLGRNY-NDESKLEPNMKWEKLFVDFLRDYKSD---RLDIAYMA 577
            .      ::..|..|..|:|||...|| ..:.|.:...:||..|:..:::|:.:   ....||||
Zfish   581 Y------DNEQYTTAEALILTFSLNNYARTDVKFKVVEEWENRFLKIVQEYQKNSTTNFTFAYMA 639

  Fly   578 ERSIQDAIVELSEGEVSTVVISYVVMFVYVAIALGHIRSCRGFLRESRIMLAIGGIVIVLASVVC 642
            |||::|.|...:..::...:|||.|:|:|:|:|||...||:..|.:|:.::.:|||::|..||:.
Zfish   640 ERSLEDEINRTTAEDIPIFMISYAVIFLYIAVALGEYSSCKRILVDSKFLVGLGGILVVGCSVIA 704

  Fly   643 SLGFWGYLDVTTTMLAIEVIPFLVLAVGVDNIFIMVHTYQRLDHSKFKTTHEAIGEAIGQVGPSI 707
            |:||:.::.|.::::.::|:||||||||.|||||.|..|||......:...|.||..:|.|.||:
Zfish   705 SMGFYAWIGVASSLVILQVVPFLVLAVGADNIFIFVLEYQRDLRRPGEQREEQIGRVLGNVAPSM 769

  Fly   708 LQTAGSEMACFAIGCISDMPAVKTFAMYAAIAILLDFLLQITAFVALMAIDEKRYLDGRLDMLCC 772
            |..:.||..||.:|.:|.|||||:||:|||:|:|:||:||:||||||:::|.:|....|.::.||
Zfish   770 LLCSLSESVCFFLGALSTMPAVKSFALYAALAVLMDFVLQMTAFVALLSLDARRQDSNRCEIACC 834

  Fly   773 VKSGGKKINDEDGDGVDRPK----EVGLLETLFKNFYSPFLLSKPVKVSVLLIFTVITCLSLMVT 833
            |.             ||.|:    ..|:|..|.:.:|:||||:...:|.|:::|.|:...|:.:.
Zfish   835 VT-------------VDTPRPQKPNEGILLPLMRKYYAPFLLNSFSRVVVMVLFLVMFFSSVFLM 886

  Fly   834 PSIEKGLDQEMSMPKNSHVVKYFRYMVDLLAMGAPVYWVLKPGLNYSEPLQQNLICGGVECNNNS 898
            ..::.||:||::||.:|:::.||.|:.....:|.|.|::...|.|::.....|.:|..|.|:..|
Zfish   887 FHVKVGLNQELAMPTDSYMLDYFAYLFKYFEVGVPTYFITTKGFNFNSEEGINAVCSSVGCDQFS 951

  Fly   899 LSVQLYTQAQYPEITSLARPASSWLDDYIDWL-AISDCCK---YNVTTGGFCSSNSKSEDCLPCE 959
            ::.::....:|||.:.||.|||||:||||||| ..|.||:   :......||.:| ::..||...
Zfish   952 MTQKIRYATEYPERSYLAIPASSWVDDYIDWLNPGSRCCRLYTFGPNKDEFCPAN-ETGVCLKKC 1015

  Fly   960 RGFTENG-LRPDAETFNKYIPYFLFDLPDAECAKAGRASYADAVIYTIDDVGMSTVQDSYFMQYS 1023
            .|..||| ||||...||:::|.||.:.||.:|.|.|..:|..||   |.|.....:..:.||.|.
Zfish  1016 MGKPENGVLRPDVSEFNRFLPDFLSNRPDLQCPKGGLGAYDKAV---IRDNETGEIIATRFMAYH 1077

  Fly  1024 TTSTTSEEFYSQLREVRRISGEIN-AMFKENNV--DAEIFAYCVFYIYYEQYLTIWGDAMFSLGM 1085
            |....|:|:...|::.|.::..|. ||.|.|:.  |.|:|.|.|.|:||||||.|..:.:|::.:
Zfish  1078 TPLVNSQEYTGALQKARELAHNITMAMRKLNDTSPDFEVFPYTVTYVYYEQYLNIVNEGLFNIAV 1142

  Fly  1086 SLVAIFLVTLLITGLDITSTFIVLFMVICILINMLGMMWAWSINLNAISLVNLVVCVGIGVEFVA 1150
            .|:..|:|..::.|:|:.|.|:.|..::.|.::.:|:|..|.|:.||:||:|||..|||.||||:
Zfish  1143 CLLPTFVVCCILLGMDLRSGFLNLLTIVMITVDTVGVMTLWGIDFNAVSLINLVTAVGISVEFVS 1207

  Fly  1151 HIVRSFK-RAEGTAQERARHSLNVTGSSVLSGITLTKFAGIVVLGFSNSQIFQVFYFRMYLGIVL 1214
            |..|||. ....|..|||:.:....||:|.:|:.:|...|||||.|:.:|:.|:|:||:.|.|.|
Zfish  1208 HTTRSFALSVRPTKVERAKEATANMGSAVFAGVAMTNLPGIVVLAFAKAQLIQIFFFRLNLVITL 1272

  Fly  1215 IGAAHGLILLPVLLSLLGP 1233
            :|.|||||.||||||..||
Zfish  1273 LGMAHGLIFLPVLLSYFGP 1291

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Npc1b	NP_608417.2	2A060601	24..1220	CDD:273337	426/1239 (34%)
		NPC1_N	24..270	CDD:293023	67/222 (30%)
		nitrilase	<265..>331	CDD:299711	23/96 (24%)
		Sterol-sensing	623..775	CDD:289145	71/151 (47%)
npc1l1	XP_021334155.1	Patched	33..1290	CDD:330476	436/1251 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55095
OrthoDB	1	1.010	-	-		D31089at33208
OrthoFinder	1	1.000	-	-		FOG0001659
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101370
Panther	1	1.100	-	-	O	PTHR45727
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X943
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.930