DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Npc1b and npc1

DIOPT Version :9

Sequence 1:	NP_608417.2	Gene:	Npc1b / 33072	FlyBaseID:	FBgn0261675	Length:	1254	Species:	Drosophila melanogaster
Sequence 2:	XP_004915269.2	Gene:	npc1 / 100494646	XenbaseID:	XB-GENE-984654	Length:	1283	Species:	Xenopus tropicalis

Alignment Length:	1300	Identity:	497/1300 - (38%)
Similarity:	708/1300 - (54%)	Gaps:	111/1300 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 TIWLIAGAWSQSAEQLGCIWYGQ--SHMIGAHWVNKGDTNPARPLNSP-TSEAIFAKRCPMLYKE 68
            |:||.....||.     |:|||:  :..:....:|...:.|  |::.| ....:..:.||.||
Frog    17 TLWLPGRVSSQH-----CVWYGECGNSTLEDKRLNCRYSGP--PISLPEEGHTLLQQLCPSLY-- 72

  Fly    69 YKGESGEDELSLCCDAAQIETMESGLSQADGVFSRCPTCTRNMALTVCAMTCAKNHTLFLTAYND 133
                .|.:  ::|||..|:.|:.|.|.......||||:|..|.....|.:||:.:.:.||.....
Frog    73 ----YGNN--TVCCDVQQLNTLNSNLQLPLQFLSRCPSCFYNFMTMFCELTCSPHQSEFLNVTQT 131

  Fly   134 TNDAGV------DYVKYIDYRLTDDTVSKIYNSCIGIQHTQTGRPAMDLGCGSYNAKTCNYRRWY 192
            ....|.      :.:..::|.:.:...:.:||:|..::...:...|:.|.||. :.|.||...|.
Frog   132 EPFVGPSPQRANESIVAMEYYIGEQFANAMYNACKDVEAPSSNVKALALLCGK-DVKDCNATNWI 195

  Fly   193 EFMGDVSGDYVPFQINYKWSEDAEEGSNEIYLDLSPLKCGESYEDSYA-CACIDCEESC-PLTDA 255
            ::|.......|||.|...:|:|..  ::.:.::.:...|.|..|:..| |:|.||..|| |:...
Frog   196 QYMFSKDNGQVPFTITPIFSDDPV--TSMLPMNNATKGCDEPVEEGGASCSCQDCALSCGPVPQP 258

  Fly   256 PTGPDELWKIAGLYGVTFILALIIACALSFF--IFWGAF--------------GKTSAPSVCMPT 304
            |..|.. |.|.||..:..|:.::....|..|  :..|::              ..|.|.||....
Frog   259 PPLPPP-WLIFGLDAMAVIMWIVYVVFLLLFSAVIIGSWCYRKKNIVSEYAPIDSTLAYSVNSTP 322

  Fly   305 LFGE-------------FFYHGFRIWGTFCAKHPVIVLALCSWAIAGLSFGIRYMTITTDPVELW 356
            :.||             |...||..||:.|.:.|.||:......|....||::||.|||||||||
Frog   323 IAGEPSCCDRLGERLENFLRIGFTKWGSICVRKPWIVIFFSVLLIVICCFGLKYMRITTDPVELW 387

  Fly   357 AGEESQTRIEKDYFDQHFGPFYRTNQMFVKAVNQTYFTHE--TSNGVLNFGPAFEYNFLKEVFEL 419
            :...||.|.||:|||.|||||:||.|:.:.|.|.:...:.  .|...:.|||..::|.|.:|.||
Frog   388 SDPHSQARQEKEYFDSHFGPFFRTEQLIITAPNSSVHNYSPYPSGSDVPFGPPLDFNILAQVLEL 452

  Fly   420 QDSIMKL-GMADNEG--LDKICYAPVLMAGETPTVDRCAIQSVYGYFQHDMDRFENSYVDSNNYT 481
            |:.|..| ...:||.  |..||.||:     .|..:.|.|.||..|||:......:|..|.....
Frog   453 QNGIENLKAYYNNETVMLKDICLAPL-----APYNNNCTIFSVLNYFQNSFSVLNHSIQDDFYVY 512

  Fly   482 INYLNQLEDCLRVP--------MMEDCFGTFGGPIEPGIAVGGMPKVAVGEDPDYMLATGLVLTF 538
            .:|......|:|.|        :.:.|.|||||||.|.:.:||.      :|.:|..||.||:||
Frog   513 ADYHTHFLYCVRSPASLNDTSVLHDPCLGTFGGPIFPWLVLGGY------DDENYNNATALVITF 571

  Fly   539 LGRNY-NDESKLEPNMKWEKLFVDFLRDYKSDRLDIAYMAERSIQDAIVELSEGEVSTVVISYVV 602
            ...|: ||..||.....||..|:.|:.:|.:..|.|::.|||||:|.|...|:.:|:||||||.:
Frog   572 PVNNFRNDTEKLNRAKAWELEFIKFVENYSNPNLSISFSAERSIEDEINRESKSDVTTVVISYAL 636

  Fly   603 MFVYVAIALGHIRSCRGFLRESRIMLAIGGIVIVLASVVCSLGFWGYLDVTTTMLAIEVIPFLVL 667
            ||||:::|||.|..|...|.:|:|.|.|.||:|||:||.||||.:.|..|:.|::.|||||||||
Frog   637 MFVYISLALGQIGHCSSILVDSKISLGIAGILIVLSSVACSLGIFSYAGVSLTLIVIEVIPFLVL 701

  Fly   668 AVGVDNIFIMVHTYQRLDHSKFKTTHEAIGEAIGQVGPSILQTAGSEMACFAIGCISDMPAVKTF 732
            |||||||:|:|..|||.:....:|..:.||..:|.|.|||..:|.:|...|.:|.:|.||||:||
Frog   702 AVGVDNIYIIVQRYQRDERLHDETLDQQIGRILGDVAPSIFLSAFAETVAFFLGALSSMPAVRTF 766

  Fly   733 AMYAAIAILLDFLLQITAFVALMAIDEKRYLDGRLDMLCCVKSGGKKINDEDGDGVDRPKEVGLL 797
            :::|.:|:.||||||||.|::|:::|.:|....|||:||||.  |.|.|    .|.|:||  ..|
Frog   767 SLFAGMAVFLDFLLQITCFISLLSLDIRRQEKNRLDILCCVP--GCKRN----RGTDKPK--SWL 823

  Fly   798 ETLFKNFYSPFLLSKPVKVSVLLIFTVITCLSLMVTPSIEKGLDQEMSMPKNSHVVKYFRYMVDL 862
            ...||..|:|.|:...::..|:.:|..|...|:.|...:|.||||.:|||.:|:::.||..:...
Frog   824 FLFFKKLYAPVLMKDWIRPIVVSVFVGILSFSIAVVNKVEIGLDQSLSMPDDSYMLDYFGSLSTY 888

  Fly   863 LAMGAPVYWVLKPGLNYSEPLQQNLICGGVECNNNSLSVQLYTQAQYPEITSLARPASSWLDDYI 927
            |..|.|||:|::.|.||:....|:.:|||..||||||..::||.|.....|.:....|||:|||.
Frog   889 LHTGPPVYFVVEEGHNYTTKEGQDKVCGGAGCNNNSLVQEIYTAAGISNYTRIGYAPSSWIDDYF 953

  Fly   928 DWL-AISDCCKYNVTTGGFCSSNSKSEDCLPCERGFTENGLR-PDAETFNKYIPYFLFDLPDAEC 990
            ||: ..|.||:....|..||:::..:..||.| |.:|..|.| |..|.|..::|.||.|.|:.:|
Frog   954 DWVKPQSTCCRIYNNTDQFCNASVVNASCLSC-RSYTPEGKRKPVGEDFMHFLPMFLSDNPNPKC 1017

  Fly   991 AKAGRASYADAVIYTIDDVGMST-VQDSYFMQYSTTSTTSEEFYSQLREVRRISGEINAMFKENN 1054
            .|.|.|:|..||    |.:..:| |..:|||.|.|....|.:|...:|:.|.|:..|.     :|
Frog  1018 GKGGHAAYGSAV----DLLDSNTNVGATYFMTYHTILKNSTDFIDAMRKARTIAQNIT-----DN 1073

  Fly  1055 VDA-----EIFAYCVFYIYYEQYLTIWGDAMFSLGMSLVAIFLVTLLITGLDITSTFIVLFMVIC 1114
            :|.     ::|.|.:||::|||||||..|.:|:|.:||.|:|.||:::.|.::.|..::...:..
Frog  1074 MDIPGKKYKVFPYSIFYVFYEQYLTIVDDTIFNLCVSLAAVFFVTVILLGFELWSAVLMCITISM 1138

  Fly  1115 ILINMLGMMWAWSINLNAISLVNLVVCVGIGVEFVAHIVRSFK-RAEGTAQERARHSLNVTGSSV 1178
            ||:||.|:||.|.|:|||:||||||:..||.|||.:|:.|:|. ...|...:||..:|...||||
Frog  1139 ILVNMFGVMWLWGISLNAVSLVNLVMSCGISVEFCSHVTRAFSVSTRGNRVQRAEDALAHMGSSV 1203

  Fly  1179 LSGITLTKFAGIVVLGFSNSQIFQVFYFRMYLGIVLIGAAHGLILLPVLLSLLGPPQKLARSSGA 1243
            .||||||||.||.|||.|.||||::|||||||.:||:|||||||.||||||.|||....|:...|
Frog  1204 FSGITLTKFVGIGVLGLSKSQIFKIFYFRMYLAMVLLGAAHGLIFLPVLLSYLGPQVNKAKVQAA 1268

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Npc1b	NP_608417.2	2A060601	24..1220	CDD:273337	477/1258 (38%)
		NPC1_N	24..270	CDD:293023	68/256 (27%)
		nitrilase	<265..>331	CDD:299711	22/94 (23%)
		Sterol-sensing	623..775	CDD:289145	79/151 (52%)
npc1	XP_004915269.2	2A060601	29..1257	CDD:273337	487/1270 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D31089at33208
OrthoFinder	1	1.000	-	-		FOG0001659
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X943
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.010