DRSC/TRiP Functional Genomics Resources

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Protein Alignment HSPA2 and Hsp70Bb

DIOPT Version :9

Sequence 1:NP_001374860.1 Gene:HSPA2 / 3306 HGNCID:5235 Length:639 Species:Homo sapiens
Sequence 2:NP_524927.2 Gene:Hsp70Bb / 48582 FlyBaseID:FBgn0013278 Length:641 Species:Drosophila melanogaster


Alignment Length:643 Identity:480/643 - (74%)
Similarity:549/643 - (85%) Gaps:12/643 - (1%)


- Green bases have known domain annotations that are detailed below.


Human     6 PAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVAMNPTNTIFD 70
            ||||||||||||||||:|||||||||||||||||||||||||:||||||.|||||||||.||:||
  Fly     2 PAIGIDLGTTYSCVGVYQHGKVEIIANDQGNRTTPSYVAFTDSERLIGDPAKNQVAMNPRNTVFD 66

Human    71 AKRLIGRKFEDATVQSDMKHWPFRVVSEGGKPKVQVEYKGETKTFFPEEISSMVLTKMKEIAEAY 135
            ||||||||::|..:..|||||||:|||:|||||:.||||||:|.|.||||||||||||||.||||
  Fly    67 AKRLIGRKYDDPKIAEDMKHWPFKVVSDGGKPKIGVEYKGESKRFAPEEISSMVLTKMKETAEAY 131

Human   136 LGGKVHSAVITVPAYFNDSQRQATKDAGTITGLNVLRIINEPTAAAIAYGLDKKGCAGGEKNVLI 200
            ||..:..|||||||||||||||||||||.|.|||||||||||||||:||||||.  ..||:||||
  Fly   132 LGESITDAVITVPAYFNDSQRQATKDAGHIAGLNVLRIINEPTAAALAYGLDKN--LKGERNVLI 194

Human   201 FDLGGGTFDVSILTIEDG-IFEVKSTAGDTHLGGEDFDNRMVSHLAEEFKRKHKKDIGPNKRAVR 264
            |||||||||||||||::| :|||:||||||||||||||||:|:|||||||||:|||:..|.||:|
  Fly   195 FDLGGGTFDVSILTIDEGSLFEVRSTAGDTHLGGEDFDNRLVTHLAEEFKRKYKKDLRSNPRALR 259

Human   265 RLRTACERAKRTLSSSTQASIEIDSLYEGVDFYTSITRARFEELNADLFRGTLEPVEKALRDAKL 329
            |||||.|||||||||||:|:||||:|:||.||||.::|||||||.|||||.||:||||||.|||:
  Fly   260 RLRTAAERAKRTLSSSTEATIEIDALFEGQDFYTKVSRARFEELCADLFRNTLQPVEKALNDAKM 324

Human   330 DKGQIQEIVLVGGSTRIPKIQKLLQDFFNGKELNKSINPDEAVAYGAAVQAAILIGDKSENVQDL 394
            |||||.:||||||||||||:|.|||:||:||.||.|||||||||||||||||||.||:|..:||:
  Fly   325 DKGQIHDIVLVGGSTRIPKVQSLLQEFFHGKNLNLSINPDEAVAYGAAVQAAILSGDQSGKIQDV 389

Human   395 LLLDVTPLSLGIETAGGVMTPLIKRNTTIPTKQTQTFTTYSDNQSSVLVQVYEGERAMTKDNNLL 459
            ||:||.||||||||||||||.||:||..||.|||:||:||||||..|.:||||||||||||||.|
  Fly   390 LLVDVAPLSLGIETAGGVMTKLIERNCRIPCKQTKTFSTYSDNQPGVSIQVYEGERAMTKDNNAL 454

Human   460 GKFDLTGIPPAPRGVPQIEVTFDIDANGILNVTAADKSTGKENKITITNDKGRLSKDDIDRMVQE 524
            |.|||:|||||||||||||||||:||||||||:|.:.||||...|||.|||||||:.:|||||.|
  Fly   455 GTFDLSGIPPAPRGVPQIEVTFDLDANGILNVSAKEMSTGKAKNITIKNDKGRLSQAEIDRMVNE 519

Human   525 AERYKSEDEANRDRVAAKNALESYTYNIKQTVEDEKLRGKISEQDKNKILDKCQEVINWLDRNQM 589
            ||:|..|||.:|.|:.::||||||.:|:||:|| :...||:.|.|||.:||||.|.|.|||.|..
  Fly   520 AEKYADEDEKHRQRITSRNALESYVFNVKQSVE-QAPAGKLDEADKNSVLDKCNETIRWLDSNTT 583

Human   590 AEKDEYEHKQKELERVCNPIISKLYQ------GGPGGGSG--GGGSGASGGPTIEEVD 639
            |||:|::||.:||.|.|:||::|::|      ||||...|  .||.|...|||:||||
  Fly   584 AEKEEFDHKMEELTRHCSPIMTKMHQQGAGAAGGPGANCGQQAGGFGGYSGPTVEEVD 641

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
HSPA2NP_001374860.1 PTZ00009 2..615 CDD:240227 464/609 (76%)
Nucleotide-binding domain (NBD). /evidence=ECO:0000250|UniProtKB:P11142 2..389 312/383 (81%)
Substrate-binding domain (SBD). /evidence=ECO:0000250|UniProtKB:P11142 397..512 89/114 (78%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 613..639 14/33 (42%)
Hsp70BbNP_524927.2 PTZ00009 2..641 CDD:240227 478/641 (75%)
HSPA1-2_6-8-like_NBD 3..379 CDD:212675 308/377 (82%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0443
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG53894
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000049
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100083
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
54.720

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