Protein Alignment HSPA2 and Hsp68

DIOPT Version :10

• Sequence 1: NP_068814.2
• Gene: HSPA2 / 3306
• HGNCID: 5235
• Length: 639
• Species: Homo sapiens
• Sequence 2: NP_524474.1
• Gene: Hsp68 / 42852
• FlyBaseID: FBgn0001230
• Length: 635
• Species: Drosophila melanogaster
• Alignment Length: 638
• Identity: 456/638 - (71%)
• Similarity: 543/638 - (85%)
• Gaps: 8/638 - (1%)

Human     6 PAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVAMNPTNTIFD 70
            ||||||||||||||||||:|||||||||||||||||||||||:||||||||||||||||.|::||
  Fly     2 PAIGIDLGTTYSCVGVFQYGKVEIIANDQGNRTTPSYVAFTDSERLIGDAAKNQVAMNPKNSVFD 66

Human    71 AKRLIGRKFEDATVQSDMKHWPFRVVSEGGKPKVQVEYKGETKTFFPEEISSMVLTKMKEIAEAY 135
            |||||||:|:|:.:|.|:|||||:|:::.||||:.||:||..|.|.||||||||||||||.||||
  Fly    67 AKRLIGRRFDDSKIQEDIKHWPFKVINDNGKPKISVEFKGANKCFSPEEISSMVLTKMKETAEAY 131

Human   136 LGGKVHSAVITVPAYFNDSQRQATKDAGTITGLNVLRIINEPTAAAIAYGLDKKGCAGGEKNVLI 200
            ||..|..|||||||||||||||||||||.|.|:|||||||||||||:||||||.  ..||:||||
  Fly   132 LGTTVKDAVITVPAYFNDSQRQATKDAGAIAGINVLRIINEPTAAALAYGLDKN--LKGERNVLI 194

Human   201 FDLGGGTFDVSILTIEDG-IFEVKSTAGDTHLGGEDFDNRMVSHLAEEFKRKHKKDIGPNKRAVR 264
            |||||||||||||||::| :|||:||||||||||||||||:|:|.|||||||:|||:..|.||:|
  Fly   195 FDLGGGTFDVSILTIDEGSLFEVRSTAGDTHLGGEDFDNRLVNHFAEEFKRKYKKDLRSNPRALR 259

Human   265 RLRTACERAKRTLSSSTQASIEIDSLYEGVDFYTSITRARFEELNADLFRGTLEPVEKALRDAKL 329
            |||||.|||||||||||:||:|||:||||.|||:.::|||||||..||||.|||||||||:|||:
  Fly   260 RLRTAAERAKRTLSSSTEASLEIDALYEGHDFYSKVSRARFEELCGDLFRNTLEPVEKALKDAKM 324

Human   330 DKGQIQEIVLVGGSTRIPKIQKLLQDFFNGKELNKSINPDEAVAYGAAVQAAILIGDKSENVQDL 394
            ||.||.:||||||||||||:|.|||:||.||.||.|||||||||||||:|||||.||||..::|:
  Fly   325 DKSQIHDIVLVGGSTRIPKVQNLLQNFFGGKTLNLSINPDEAVAYGAAIQAAILSGDKSSEIKDV 389

Human   395 LLLDVTPLSLGIETAGGVMTPLIKRNTTIPTKQTQTFTTYSDNQSSVLVQVYEGERAMTKDNNLL 459
            ||:||.||||||||||||||.||:||:.||.||::|||||:|||.:|.:||:|||||:|||||:|
  Fly   390 LLVDVAPLSLGIETAGGVMTKLIERNSRIPCKQSKTFTTYADNQPAVTIQVFEGERALTKDNNVL 454

Human   460 GKFDLTGIPPAPRGVPQIEVTFDIDANGILNVTAADKSTGKENKITITNDKGRLSKDDIDRMVQE 524
            |.|||||:||||||||:|:||||:||||||||||.::.||....|||.|||||||:.|||||:.|
  Fly   455 GTFDLTGVPPAPRGVPKIDVTFDLDANGILNVTAKEQGTGNAKNITIKNDKGRLSQADIDRMLSE 519

Human   525 AERYKSEDEANRDRVAAKNALESYTYNIKQTVEDEKLRGKISEQDKNKILDKCQEVINWLDRNQM 589
            ||:|..|||.:|.|:||:|.||:|.:.:|:..|:.  ..:||..||:.|:::|.|.:.|||.|..
  Fly   520 AEKYAEEDERHRQRIAARNQLETYLFGVKEAAENG--GDRISAADKSSIVERCSEAMKWLDSNTT 582

Human   590 AEKDEYEHKQKELERVCNPIISKLYQGGPGGGSG---GGGSGASGGPTIEEVD 639
            |||:|||:|.||||:.|:||::|:::||..|...   |..:|...|||:||||
  Fly   583 AEKEEYEYKLKELEQFCSPIMTKMHKGGGDGQQAPNFGQQAGGYKGPTVEEVD 635

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HSPA2	NP_068814.2	PTZ00009	2..615	CDD:240227	444/609 (73%)
		Nucleotide-binding domain (NBD). /evidence=ECO:0000250|UniProtKB:P11142	2..389		305/383 (80%)
		Substrate-binding domain (SBD). /evidence=ECO:0000250|UniProtKB:P11142	397..512		83/114 (73%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	613..639		10/28 (36%)
Hsp68	NP_524474.1	PTZ00009	2..635	CDD:240227	454/636 (71%)