Protein Alignment HSPA2 and Hsc70-4

DIOPT Version :10

• Sequence 1: NP_068814.2
• Gene: HSPA2 / 3306
• HGNCID: 5235
• Length: 639
• Species: Homo sapiens
• Sequence 2: NP_524356.1
• Gene: Hsc70-4 / 41840
• FlyBaseID: FBgn0266599
• Length: 651
• Species: Drosophila melanogaster
• Alignment Length: 652
• Identity: 531/652 - (81%)
• Similarity: 583/652 - (89%)
• Gaps: 17/652 - (2%)

Human     3 ARGPAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVAMNPTNT 67
            ::.||:|||||||||||||||||||||||||||||||||||||||||||||||||||||||||.|
  Fly     2 SKAPAVGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVAMNPTQT 66

Human    68 IFDAKRLIGRKFEDATVQSDMKHWPFRVVSEGGKPKVQVEYKGETKTFFPEEISSMVLTKMKEIA 132
            ||||||||||||:||.||||||||||.|||..||||::|.||.|.||||||||||||||||||.|
  Fly    67 IFDAKRLIGRKFDDAAVQSDMKHWPFEVVSADGKPKIEVTYKDEKKTFFPEEISSMVLTKMKETA 131

Human   133 EAYLGGKVHSAVITVPAYFNDSQRQATKDAGTITGLNVLRIINEPTAAAIAYGLDKKGCAGGEKN 197
            |||||..|.:|||||||||||||||||||||||.|||||||||||||||||||||||  |.||:|
  Fly   132 EAYLGKTVTNAVITVPAYFNDSQRQATKDAGTIAGLNVLRIINEPTAAAIAYGLDKK--AVGERN 194

Human   198 VLIFDLGGGTFDVSILTIEDGIFEVKSTAGDTHLGGEDFDNRMVSHLAEEFKRKHKKDIGPNKRA 262
            ||||||||||||||||:|:|||||||||||||||||||||||:|:|..:|||||||||:..||||
  Fly   195 VLIFDLGGGTFDVSILSIDDGIFEVKSTAGDTHLGGEDFDNRLVTHFVQEFKRKHKKDLTTNKRA 259

Human   263 VRRLRTACERAKRTLSSSTQASIEIDSLYEGVDFYTSITRARFEELNADLFRGTLEPVEKALRDA 327
            :|||||||||||||||||||||||||||:||.||||||||||||||||||||.|::|||||||||
  Fly   260 LRRLRTACERAKRTLSSSTQASIEIDSLFEGTDFYTSITRARFEELNADLFRSTMDPVEKALRDA 324

Human   328 KLDKGQIQEIVLVGGSTRIPKIQKLLQDFFNGKELNKSINPDEAVAYGAAVQAAILIGDKSENVQ 392
            ||||..|.:||||||||||||:|:||||.|||||||||||||||||||||||||||.||||:.||
  Fly   325 KLDKSVIHDIVLVGGSTRIPKVQRLLQDLFNGKELNKSINPDEAVAYGAAVQAAILHGDKSQEVQ 389

Human   393 DLLLLDVTPLSLGIETAGGVMTPLIKRNTTIPTKQTQTFTTYSDNQSSVLVQVYEGERAMTKDNN 457
            |||||||||||||||||||||:.|||||||||||||||||||||||..||:||||||||||||||
  Fly   390 DLLLLDVTPLSLGIETAGGVMSVLIKRNTTIPTKQTQTFTTYSDNQPGVLIQVYEGERAMTKDNN 454

Human   458 LLGKFDLTGIPPAPRGVPQIEVTFDIDANGILNVTAADKSTGKENKITITNDKGRLSKDDIDRMV 522
            |||||:|:||||||||||||||||||||||||||||.::||.||||||||||||||||:||:|||
  Fly   455 LLGKFELSGIPPAPRGVPQIEVTFDIDANGILNVTALERSTNKENKITITNDKGRLSKEDIERMV 519

Human   523 QEAERYKSEDEANRDRVAAKNALESYTYNIKQTVEDEKLRGKISEQDKNKILDKCQEVINWLDRN 587
            .|||:|::|||..::.:||||.||||.:|:|.|::::.|:.|||:.|:..|||||.|.|.|||.|
  Fly   520 NEAEKYRNEDEKQKETIAAKNGLESYCFNMKATLDEDNLKTKISDSDRTTILDKCNETIKWLDAN 584

Human   588 QMAEKDEYEHKQKELERVCNPIISKLYQ----------GGPGG--GSGG--GGSGASG-GPTIEE 637
            |:|:|:||||:|||||.||||||:||||          |||||  |:.|  |.:||.| ||||||
  Fly   585 QLADKEEYEHRQKELEGVCNPIITKLYQGAGFPPGGMPGGPGGMPGAAGAAGAAGAGGAGPTIEE 649

Human   638 VD 639
            ||
  Fly   650 VD 651

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HSPA2	NP_068814.2	PTZ00009	2..615	CDD:240227	510/611 (83%)
		Nucleotide-binding domain (NBD). /evidence=ECO:0000250|UniProtKB:P11142	2..389		336/385 (87%)
		Substrate-binding domain (SBD). /evidence=ECO:0000250|UniProtKB:P11142	397..512		103/114 (90%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	613..639		20/40 (50%)
Hsc70-4	NP_524356.1	PTZ00009	1..612	CDD:240227	510/611 (83%)