DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment HSPA2 and Hsc70-2

DIOPT Version :9

Sequence 1:	NP_001374860.1	Gene:	HSPA2 / 3306	HGNCID:	5235	Length:	639	Species:	Homo sapiens
Sequence 2:	NP_524339.1	Gene:	Hsc70-2 / 41609	FlyBaseID:	FBgn0001217	Length:	633	Species:	Drosophila melanogaster

Alignment Length:	635	Identity:	459/635 - (72%)
Similarity:	537/635 - (84%)	Gaps:	8/635 - (1%)

- Green bases have known domain annotations that are detailed below.

Human     6 PAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVAMNPTNTIFD 70
            ||||||||||||||||:|:.||||||||||||||||||||.:|||||||.||||||||..||:||
  Fly     5 PAIGIDLGTTYSCVGVWQNSKVEIIANDQGNRTTPSYVAFNETERLIGDPAKNQVAMNAKNTVFD 69

Human    71 AKRLIGRKFEDATVQSDMKHWPFRVVSEGGKPKVQVEYKGETKTFFPEEISSMVLTKMKEIAEAY 135
            |||||||||:|..:|.|:|.|||:|::|.||||::||:|||.|.|.||||||||||||:||||.|
  Fly    70 AKRLIGRKFDDKKIQEDLKLWPFKVINEKGKPKIEVEFKGERKRFAPEEISSMVLTKMREIAEVY 134

Human   136 LGGKVHSAVITVPAYFNDSQRQATKDAGTITGLNVLRIINEPTAAAIAYGLDKKGCAGGEKNVLI 200
            |||||..||:||||||||||||||||||:|.|||||||||||||||:||||||.  ..||:||||
  Fly   135 LGGKVKDAVVTVPAYFNDSQRQATKDAGSIAGLNVLRIINEPTAAALAYGLDKN--LKGERNVLI 197

Human   201 FDLGGGTFDVSILTIEDG-IFEVKSTAGDTHLGGEDFDNRMVSHLAEEFKRKHKKDIGPNKRAVR 264
            |||||||||||:|:|::| :||||:|||||||||||||||:|:|.|||||||||.||..|.||:|
  Fly   198 FDLGGGTFDVSVLSIDEGSLFEVKATAGDTHLGGEDFDNRLVNHFAEEFKRKHKSDIKGNARALR 262

Human   265 RLRTACERAKRTLSSSTQASIEIDSLYEGVDFYTSITRARFEELNADLFRGTLEPVEKALRDAKL 329
            |||||||||||||||||:||:|||:|:||:|||:.|:||||||||.||||.|::|||:||.|||:
  Fly   263 RLRTACERAKRTLSSSTEASLEIDALHEGIDFYSKISRARFEELNMDLFRSTMQPVERALSDAKM 327

Human   330 DKGQIQEIVLVGGSTRIPKIQKLLQDFFNGKELNKSINPDEAVAYGAAVQAAILIGDKSENVQDL 394
            ||..|.::||||||||||||||||||.|.||:||.|||||||||||||||||||.|..|..:|||
  Fly   328 DKKAIHDVVLVGGSTRIPKIQKLLQDLFGGKQLNLSINPDEAVAYGAAVQAAILTGVGSSQIQDL 392

Human   395 LLLDVTPLSLGIETAGGVMTPLIKRNTTIPTKQTQTFTTYSDNQSSVLVQVYEGERAMTKDNNLL 459
            ||:||.||||||||||||||.|::||..||.||.|.||||||||::|.:||||||||||||||||
  Fly   393 LLVDVAPLSLGIETAGGVMTNLVERNARIPCKQQQIFTTYSDNQNAVTIQVYEGERAMTKDNNLL 457

Human   460 GKFDLTGIPPAPRGVPQIEVTFDIDANGILNVTAADKSTGKENKITITNDKGRLSKDDIDRMVQE 524
            |.|:||||||||||||||||.||::|:|||||.|.|.||||..||||:||||||||.:||||:.|
  Fly   458 GTFNLTGIPPAPRGVPQIEVAFDLNADGILNVNAKDNSTGKSEKITISNDKGRLSKAEIDRMLSE 522

Human   525 AERYKSEDEANRDRVAAKNALESYTYNIKQTVEDEKLRGKISEQDKNKILDKCQEVINWLDRNQM 589
            ||:||.||:..|:||.:||.||:|.|..:|.|:|.. .|.:||.:::|:.|||....:|||:|.:
  Fly   523 AEKYKVEDDRQRERVQSKNNLEAYIYACRQAVDDAP-SGVLSETERSKVRDKCSSEASWLDKNSL 586

Human   590 AEKDEYEHKQKELERVCNPIISKLYQGGPGGGSGGGGSGASGGPTIEEVD 639
            |||:|:|...||.:|:|.||:||::.|..|..|.|.||    .||:||||
  Fly   587 AEKEEFESHLKECQRICTPIMSKIHGGKKGKSSMGKGS----HPTVEEVD 632

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HSPA2	NP_001374860.1	PTZ00009	2..615	CDD:240227	447/609 (73%)
		Nucleotide-binding domain (NBD). /evidence=ECO:0000250\|UniProtKB:P11142	2..389		301/383 (79%)
		Substrate-binding domain (SBD). /evidence=ECO:0000250\|UniProtKB:P11142	397..512		88/114 (77%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	613..639		10/25 (40%)
Hsc70-2	NP_524339.1	PTZ00009	1..632	CDD:240227	457/633 (72%)
Hsc70-2	NP_524339.1	HSPA1-2_6-8-like_NBD	6..382	CDD:212675	298/377 (79%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0443
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53894
OrthoDB	1	1.010	-	-		D180577at33208
OrthoFinder	1	1.000	-	-		FOG0000049
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100083
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.730