Protein Alignment HSPA2 and Hsc70-3

DIOPT Version :10

• Sequence 1: NP_068814.2
• Gene: HSPA2 / 3306
• HGNCID: 5235
• Length: 639
• Species: Homo sapiens
• Sequence 2: NP_511132.2
• Gene: Hsc70-3 / 32133
• FlyBaseID: FBgn0001218
• Length: 656
• Species: Drosophila melanogaster
• Alignment Length: 627
• Identity: 393/627 - (62%)
• Similarity: 493/627 - (78%)
• Gaps: 7/627 - (1%)

Human     5 GPAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFT-DTERLIGDAAKNQVAMNPTNTI 68
            |..||||||||||||||:::|:|||||||||||.|||||||| |.|||||||||||:..||.||:
  Fly    29 GTVIGIDLGTTYSCVGVYKNGRVEIIANDQGNRITPSYVAFTADGERLIGDAAKNQLTTNPENTV 93

Human    69 FDAKRLIGRKFEDATVQSDMKHWPFRVVSEGGKPKVQVEYKGETKTFFPEEISSMVLTKMKEIAE 133
            |||||||||::.|..||.|:|.:||:||.:..||.:.|:.....|.|.|||||:|||.||||.||
  Fly    94 FDAKRLIGREWSDTNVQHDIKFFPFKVVEKNSKPHISVDTSQGAKVFAPEEISAMVLGKMKETAE 158

Human   134 AYLGGKVHSAVITVPAYFNDSQRQATKDAGTITGLNVLRIINEPTAAAIAYGLDKKGCAGGEKNV 198
            ||||.||..||:||||||||:|||||||||.|.||.|:||||||||||||||||||   .|||||
  Fly   159 AYLGKKVTHAVVTVPAYFNDAQRQATKDAGVIAGLQVMRIINEPTAAAIAYGLDKK---EGEKNV 220

Human   199 LIFDLGGGTFDVSILTIEDGIFEVKSTAGDTHLGGEDFDNRMVSHLAEEFKRKHKKDIGPNKRAV 263
            |:|||||||||||:|||::|:|||.:|.|||||||||||.|::.|..:.:|:|..|||..:.|||
  Fly   221 LVFDLGGGTFDVSLLTIDNGVFEVVATNGDTHLGGEDFDQRVMDHFIKLYKKKKGKDIRKDNRAV 285

Human   264 RRLRTACERAKRTLSSSTQASIEIDSLYEGVDFYTSITRARFEELNADLFRGTLEPVEKALRDAK 328
            ::||...|:|||.||.|.|..|||:|.:||.||..::|||:|||||.||||.||:||:|.|.||.
  Fly   286 QKLRREVEKAKRALSGSHQVRIEIESFFEGDDFSETLTRAKFEELNLDLFRSTLKPVQKVLEDAD 350

Human   329 LDKGQIQEIVLVGGSTRIPKIQKLLQDFFNGKELNKSINPDEAVAYGAAVQAAILIGDKSENVQD 393
            ::|..:.|||||||||||||:|:|::|||.|||.::.|||||||||||||||.:|.|:  ::...
  Fly   351 MNKKDVHEIVLVGGSTRIPKVQQLVKDFFGGKEPSRGINPDEAVAYGAAVQAGVLSGE--QDTDA 413

Human   394 LLLLDVTPLSLGIETAGGVMTPLIKRNTTIPTKQTQTFTTYSDNQSSVLVQVYEGERAMTKDNNL 458
            ::||||.||::||||.|||||.||.|||.||||::|.|:|.||||.:|.:|||||||.|||||:|
  Fly   414 IVLLDVNPLTMGIETVGGVMTKLIPRNTVIPTKKSQVFSTASDNQHTVTIQVYEGERPMTKDNHL 478

Human   459 LGKFDLTGIPPAPRGVPQIEVTFDIDANGILNVTAADKSTGKENKITITNDKGRLSKDDIDRMVQ 523
            |||||||||||||||:|||||:|:|||||||.|:|.||.||.:.||.||||:.||:.:|||||::
  Fly   479 LGKFDLTGIPPAPRGIPQIEVSFEIDANGILQVSAEDKGTGNKEKIVITNDQNRLTPEDIDRMIR 543

Human   524 EAERYKSEDEANRDRVAAKNALESYTYNIKQTVED-EKLRGKISEQDKNKILDKCQEVINWLDRN 587
            :||::..||:..::||.::|.||||.|::|..:.| :||..|:|:.:|||:.....|.|.||::|
  Fly   544 DAEKFADEDKKLKERVESRNELESYAYSLKNQIGDKDKLGAKLSDDEKNKLESAIDESIKWLEQN 608

Human   588 QMAEKDEYEHKQKELERVCNPIISKLYQGGPGGGSGGGGSGA 629
            ..|:.:||:.::|:||.:..|:|:|||||..|.....||..|
  Fly   609 PDADPEEYKKQKKDLEAIVQPVIAKLYQGAGGAPPPEGGDDA 650

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HSPA2	NP_068814.2	PTZ00009	2..615	CDD:240227	386/611 (63%)
		Nucleotide-binding domain (NBD). /evidence=ECO:0000250|UniProtKB:P11142	2..389		258/384 (67%)
		Substrate-binding domain (SBD). /evidence=ECO:0000250|UniProtKB:P11142	397..512		84/114 (74%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	613..639		8/17 (47%)
Hsc70-3	NP_511132.2	PTZ00009	32..643	CDD:240227	389/615 (63%)