DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment run and runx2b

DIOPT Version :9

Sequence 1:	NP_001285501.1	Gene:	run / 33059	FlyBaseID:	FBgn0003300	Length:	510	Species:	Drosophila melanogaster
Sequence 2:	NP_998027.2	Gene:	runx2b / 405788	ZFINID:	ZDB-GENE-040629-4	Length:	464	Species:	Danio rerio

Alignment Length:	480	Identity:	160/480 - (33%)
Similarity:	223/480 - (46%)	Gaps:	84/480 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    72 TPDLSTNNTSSSSNA-TTSPQNSAKMPSSMTDMFASLHEMLQEYHGELAQTGSPSILCSALPNHW 135
            :|.:|......:||| ....|:.|.:|........|:.|::.::..||.:|.||:.|||.||:||
Zfish    28 SPPVSVKMNDVNSNAGPQQQQDGAVVPRLRAQENRSMAEIIADHPAELVRTDSPNFLCSVLPSHW 92

  Fly   136 RSNKSLPGAFKVIALDDVPDGTLVSIKCGNDENYCGELRNCTTTMKNQVAKFNDLRFVGRSGRGK 200
            |.||:||.||||:||.:|||||:|::..||||||..||||.:..||||||:||||||||||||||
Zfish    93 RCNKTLPVAFKVVALGEVPDGTVVTVMAGNDENYSAELRNASGVMKNQVARFNDLRFVGRSGRGK 157

  Fly   201 SFTLTITIATYPVQIASYSKAIKVTVDGPREPRSKQSY--GYPHPGAFNPFMLNPAWLDAAYMTY 263
            |||||||:.|.|.|:|:|.:|||||||||||||..:..  ..|..|.|:..:
Zfish   158 SFTLTITVFTNPPQVATYHRAIKVTVDGPREPRRHRPKLDDSPKAGLFSDRL------------- 209

  Fly   264 GYADYFRHQAAAQAAQVHHPALAKSSASSVSPN-----PNPSVATSSSSAVQPSEYP---HPAAA 320
            ...:..|............|..:.||.:|.:|.     .:|..|.||........||   .|.|:
Zfish   210 SELERIRQTTMRVTVPTQTPRPSLSSPNSYTPQGQTQITDPRQAQSSPPWSYDQTYPSYLSPMAS 274

  Fly   321 VAAAAGQP-----AAMMPS----P---PGAAPATPYAIP-----QFPFNHVAAAAAAKAATPHAF 368
            .:..:..|     |..:||    |   ||:...:|:  |     |||  ..::...::.::|...
Zfish   275 PSVHSTTPLSSSRATGLPSISDVPRRLPGSTDLSPF--PGQFERQFP--AFSSLTESRFSSPRMH 335

  Fly   369 HPYNFA-----AAAGLRARNAALHHQSEPVHVSPASSRPSSSSPTQQHVLLKLNTSIETSSIHEQ 428
            :|..|.     ...|:...:|..|....|.:  |.|:: |.|.|.|         |..|..:: .
Zfish   336 YPATFTYTPTPVTTGMSLGSAHYHTYLPPPY--PGSTQ-SQSGPFQ---------SSSTPYLY-Y 387

  Fly   429 SASDGDSDDEQIDVVKSEFDLDKSLDVAPLRMRCDLKAPSAMKPLYHES------GPGAVA--NS 485
            .||.|          ..:|.:....:.:|.||.....:.|....|.:.:      |.|.|.  .|
Zfish   388 GASSG----------SYQFSMVPGGERSPTRMMPPCTSASTGTSLVNPNLPVQADGSGGVEGDGS 442

  Fly   486 RQPSPETTTKIKSAAVQQKTVWRPY 510
            ...||   |.:..|....:.|||||
Zfish   443 HSNSP---TLLNPAGRMDEGVWRPY 464

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
run	NP_001285501.1	Runt	114..235	CDD:279225	84/120 (70%)
runx2b	NP_998027.2	Runt	71..192	CDD:279225	84/120 (70%)
runx2b	NP_998027.2	RunxI	370..464	CDD:285676	26/117 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170575057
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	191	1.000	Inparanoid score	I3856
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000993
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11950
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3284
SonicParanoid	1	1.000	-	-		X738
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	6.110