DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment run and Runx3

DIOPT Version :9

Sequence 1:	NP_001285501.1	Gene:	run / 33059	FlyBaseID:	FBgn0003300	Length:	510	Species:	Drosophila melanogaster
Sequence 2:	NP_569109.1	Gene:	Runx3 / 156726	RGDID:	620082	Length:	409	Species:	Rattus norvegicus

Alignment Length:	497	Identity:	155/497 - (31%)
Similarity:	218/497 - (43%)	Gaps:	125/497 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 IAINPAQSLANTSTHSA-SSTGSSTPDLSTNNTSSSSNATTSPQNSAKMPS--SMTDMFASLHEM 110
            |.::|:.|...|...:| ...|.....:..|:.:.|:.|...|....: |.  ||.|:.|
  Rat     3 IPVDPSTSRRFTPPSTAFPCGGGGGGKMGENSGALSAQAAAGPGGRTR-PEVRSMVDVLA----- 61

  Fly   111 LQEYHGELAQTGSPSILCSALPNHWRSNKSLPGAFKVIALDDVPDGTLVSIKCGNDENYCGELRN 175
              ::.|||.:|.||:.|||.||:|||.||:||.||||:||.||||||:|::..||||||..||||
  Rat    62 --DHAGELVRTDSPNFLCSVLPSHWRCNKTLPVAFKVVALGDVPDGTVVTVMAGNDENYSAELRN 124

  Fly   176 CTTTMKNQVAKFNDLRFVGRSGRGKSFTLTITIATYPVQIASYSKAIKVTVDGPREPRSKQSYGY 240
            .:..||||||:|||||||||||||||||||||:.|.|.|:|:|.:|||||||||||||..:.
  Rat   125 ASAVMKNQVARFNDLRFVGRSGRGKSFTLTITVFTNPTQVATYHRAIKVTVDGPREPRRHRQ--- 186

  Fly   241 PHPGAFNPFMLNPAWLDAAYMTYGYADYFRHQAAAQAAQVHHPALAKSSASSVSPNPNPSVATS- 304
                            .....|..:.|.|..              .:...:..:|:|..|::|:
  Rat   187 ----------------KIEDQTKAFPDRFGD--------------LRMRVTPSTPSPRGSLSTTS 221

  Fly   305 --SSSAVQPSEYPHPAAAVAAAAGQPAAMMPSPPGAAPATPYAIP----------------QFPF 351
              ||.|..|.:                       |::...|::.|                :||.
  Rat   222 HFSSQAQTPIQ-----------------------GSSDLNPFSDPRQFDRSFPTLQSLTESRFPE 263

  Fly   352 NHVAAAAAAKAATPHAFHPYNFA----AAAGLRARNAALHHQ--SEPVHVSPAS-SRPSSSSPTQ 409
            ..:....|..||.|::..|...:    :.||:.| ::..||.  ..|...:|.| |.|..::|..
  Rat   264 GRMHYPGAMSAAFPYSATPSGTSLGGLSVAGMPA-SSRFHHTYLPPPYPGAPQSQSGPFQANPAP 327

  Fly   410 QHVLLKLNTSIETSSIHEQSASDGDSDDEQIDVVKSEFDLDKSLDVAPLRM--RC----DLKAPS 468
            .|  |...||..:......:|..|:.                    :|.||  .|    .:.|.:
  Rat   328 YH--LFYGTSSGSYQFSMAAAGGGER--------------------SPTRMLTSCPTGASVSAGN 370

  Fly   469 AMKPLYHESGPGAVANSRQPSPETTTKIKSAAVQQKTVWRPY 510
            .|.|...::.......|...||   |.:.:.....:.|||||
  Rat   371 LMNPSLGQADGVEADGSHSNSP---TALSTPGRMDEAVWRPY 409

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
run	NP_001285501.1	Runt	114..235	CDD:279225	86/120 (72%)
Runx3	NP_569109.1	Runt	63..184	CDD:279225	86/120 (72%)
Runx3	NP_569109.1	RunxI	314..409	CDD:285676	25/119 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166335822
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000993
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11950
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X738
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	5.030