Protein Alignment run and Runx1

DIOPT Version :10

• Sequence 1: NP_523424.2
• Gene: run / 33059
• FlyBaseID: FBgn0003300
• Length: 510
• Species: Drosophila melanogaster
• Sequence 2: NP_001104491.1
• Gene: Runx1 / 12394
• MGIID: 99852
• Length: 465
• Species: Mus musculus
• Alignment Length: 535
• Identity: 162/535 - (30%)
• Similarity: 222/535 - (41%)
• Gaps: 179/535 - (33%)

  Fly    65 ASSTGSSTPDLSTNNTSSSSNATT--SPQNSAKMPSSMTDMFASLHEMLQEYHGELAQTGSPSIL 127
            ||::...||..:..:....|.|..  :|...|.:.|.:.....|:.|:|.::.|||.:|.||:.|
Mouse    21 ASTSRRFTPPSTALSPGKMSEALPLGAPDGGAALASKLRSGDRSMVEVLADHPGELVRTDSPNFL 85

  Fly   128 CSALPNHWRSNKSLPGAFKVIALDDVPDGTLVSIKCGNDENYCGELRNCTTTMKNQVAKFNDLRF 192
            ||.||.|||.||:||.||||:||.||||||||::..||||||..||||.|..||||||:||||||
Mouse    86 CSVLPTHWRCNKTLPIAFKVVALGDVPDGTLVTVMAGNDENYSAELRNATAAMKNQVARFNDLRF 150

  Fly   193 VGRSGRGKSFTLTITIATYPVQIASYSKAIKVTVDGPREPRSKQSY--GYPHPGAFNPFMLNPAW 255
            |||||||||||||||:.|.|.|:|:|.:|||:|||||||||..:..  ....||:.: |....:.
Mouse   151 VGRSGRGKSFTLTITVFTNPPQVATYHRAIKITVDGPREPRRHRQKLDDQTKPGSLS-FSERLSE 214

  Fly   256 LDAAYMTYGYADYFRHQAAAQAAQVHHPALAKSSASSVSPNPNPSVATSSSSA------------ 308
            |:....|            |.....||||          |.|||..:.:.|:|
Mouse   215 LEQLRRT------------AMRVSPHHPA----------PTPNPRASLNHSTAFNPQPQSQMQDA 257

  Fly   309 --VQPS---------EY--------PHPAAAVA------------------------AAAGQPAA 330
              :|||         :|        .|||..::                        .|.|.|..
Mouse   258 RQIQPSPPWSYDQSYQYLGSITSSSVHPATPISPGRASGMTSLSAELSSRLSTAPDLTAFGDPRQ 322

  Fly   331 MMPSP---------PGAAPATP---------------------YAIPQFPFNHVAAAAAAKAATP 365
            ....|         |||...:|                     |..|.:|.:..|.|...:..:|
Mouse   323 FPTLPSISDPRMHYPGAFTYSPPVTSGIGIGMSAMSSASRYHTYLPPPYPGSSQAQAGPFQTGSP 387

  Fly   366 HAFHPYNFAAAAGLRARNAALHHQSEPVHVSPASSRPSSSSPTQQHVLLKLNTSIETSSIHEQSA 430
             ::|.| :.|:||....:.....:|.|..:.|.::..:.::        .||.|:.:.|
Mouse   388 -SYHLY-YGASAGSYQFSMVGGERSPPRILPPCTNASTGAA--------LLNPSLPSQS------ 436

  Fly   431 SDGDSDDEQIDVVKSEFDLDKSLDVAPLRMRCDLKAPSAMKPLYHESGPGAVANSRQPSPETTTK 495
                      |||::|                                 |:.:||....|
Mouse   437 ----------DVVETE---------------------------------GSHSNSPTNMP----- 453

  Fly   496 IKSAAVQQKTVWRPY 510
               .|..::.|||||
Mouse   454 ---PARLEEAVWRPY 465

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
run	NP_523424.2	Runt	107..235	CDD:459963	89/127 (70%)
Runx1	NP_001104491.1	Runt	65..193	CDD:459963	89/127 (70%)
		RunxI	375..465	CDD:430037	27/156 (17%)