Protein Alignment run and Runx2

DIOPT Version :9

• Sequence 1: NP_001285501.1
• Gene: run / 33059
• FlyBaseID: FBgn0003300
• Length: 510
• Species: Drosophila melanogaster
• Sequence 2: NP_001139510.1
• Gene: Runx2 / 12393
• MGIID: 99829
• Length: 528
• Species: Mus musculus
• Alignment Length: 559
• Identity: 172/559 - (30%)
• Similarity: 233/559 - (41%)
• Gaps: 175/559 - (31%)

  Fly    18 AAAAAAAAAAAAAVAQGPGPQ---QSSNATTASAIAINPAQSLANTSTHSASSTGSSTPDLSTNN 79
            |||||||||||||.|....|:   ...|.|....||.:||
Mouse    79 AAAAAAAAAAAAAAAAAAVPRLRPPHDNRTMVEIIADHPA------------------------- 118

  Fly    80 TSSSSNATTSPQNSAKMPSSMTDMFASLHEMLQEYHGELAQTGSPSILCSALPNHWRSNKSLPGA 144
                                                 ||.:|.||:.|||.||:|||.||:||.|
Mouse   119 -------------------------------------ELVRTDSPNFLCSVLPSHWRCNKTLPVA 146

  Fly   145 FKVIALDDVPDGTLVSIKCGNDENYCGELRNCTTTMKNQVAKFNDLRFVGRSGRGKSFTLTITIA 209
            |||:||.:|||||:|::..||||||..||||.:..||||||:|||||||||||||||||||||:.
Mouse   147 FKVVALGEVPDGTVVTVMAGNDENYSAELRNASAVMKNQVARFNDLRFVGRSGRGKSFTLTITVF 211

  Fly   210 TYPVQIASYSKAIKVTVDGPREPR--------SKQSY---------GYPH--------------- 242
            |.|.|:|:|.:|||||||||||||        ||.|.         ..||
Mouse   212 TNPPQVATYHRAIKVTVDGPREPRRHRQKLDDSKPSLFSDRLSDLGRIPHPSMRVGVPPQNPRPS 276

  Fly   243 ----PGAFNP-----------FMLNPAW-LDAAYMTYGYADYFRHQAAAQAAQVHHPALAKSSAS 291
                |..|||           ...:|.| .|.:|.:|                     |::.::.
Mouse   277 LNSAPSPFNPQGQSQITDPRQAQSSPPWSYDQSYPSY---------------------LSQMTSP 320

  Fly   292 SV-SPNPNPSVATSSSSAVQ--PSEYPHPAAAVAAAAGQPAAM-MPSPPGAAPATPYAIP-QFPF 351
            |: |..|..|...:...|:.  |........|.:.....|::: ..|..||:...|::.| |||
Mouse   321 SIHSTTPLSSTRGTGLPAITDVPRRISDDDTATSDFCLWPSSLSKKSQAGASELGPFSDPRQFP- 384

  Fly   352 NHVAAAAAAKAATPHAFHPYNFA----AAAGLR-ARNAALHHQSEPVHVSPASSRPSSSSPTQQH 411
             .:::...::.:.|...:|..|.    ..:|:. ..:|..|:.:......|.||: |.|.|.|
Mouse   385 -SISSLTESRFSNPRMHYPATFTYTPPVTSGMSLGMSATTHYHTYLPPPYPGSSQ-SQSGPFQ-- 445

  Fly   412 VLLKLNTSIETSSIHEQSASDGDSDDEQIDVVKSEFDLDKSLDVAPLRM--RCDL--KAPSAMKP 472
                  || .|..::..::|           ...:|.:....|.:|.||  .|..  ...:.:.|
Mouse   446 ------TS-STPYLYYGTSS-----------ASYQFPMVPGGDRSPSRMVPPCTTTSNGSTLLNP 492

  Fly   473 LYHESGPGAVAN-SRQPSPETTTKIKSAAVQQKTVWRPY 510
            .......|..|: |...||   |.:.|:....::|||||
Mouse   493 NLPNQNDGVDADGSHSSSP---TVLNSSGRMDESVWRPY 528

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
run	NP_001285501.1	Runt	114..235	CDD:279225	84/128 (66%)
Runx2	NP_001139510.1	Runt	116..237	CDD:279225	86/182 (47%)
		RunxI	437..528	CDD:285676	26/114 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832158
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3982
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	202	1.000	Inparanoid score	I3748
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000993
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11950
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3284
SonicParanoid	1	1.000	-	-		X738
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	8	7.970