Protein Alignment run and Runx2

DIOPT Version :10

• Sequence 1: NP_523424.2
• Gene: run / 33059
• FlyBaseID: FBgn0003300
• Length: 510
• Species: Drosophila melanogaster
• Sequence 2: NP_033950.2
• Gene: Runx2 / 12393
• MGIID: 99829
• Length: 528
• Species: Mus musculus
• Alignment Length: 559
• Identity: 172/559 - (30%)
• Similarity: 233/559 - (41%)
• Gaps: 175/559 - (31%)

  Fly    18 AAAAAAAAAAAAAVAQGPGPQ---QSSNATTASAIAINPAQSLANTSTHSASSTGSSTPDLSTNN 79
            |||||||||||||.|....|:   ...|.|....||.:||
Mouse    79 AAAAAAAAAAAAAAAAAAVPRLRPPHDNRTMVEIIADHPA------------------------- 118

  Fly    80 TSSSSNATTSPQNSAKMPSSMTDMFASLHEMLQEYHGELAQTGSPSILCSALPNHWRSNKSLPGA 144
                                                 ||.:|.||:.|||.||:|||.||:||.|
Mouse   119 -------------------------------------ELVRTDSPNFLCSVLPSHWRCNKTLPVA 146

  Fly   145 FKVIALDDVPDGTLVSIKCGNDENYCGELRNCTTTMKNQVAKFNDLRFVGRSGRGKSFTLTITIA 209
            |||:||.:|||||:|::..||||||..||||.:..||||||:|||||||||||||||||||||:.
Mouse   147 FKVVALGEVPDGTVVTVMAGNDENYSAELRNASAVMKNQVARFNDLRFVGRSGRGKSFTLTITVF 211

  Fly   210 TYPVQIASYSKAIKVTVDGPREPR--------SKQSY---------GYPH--------------- 242
            |.|.|:|:|.:|||||||||||||        ||.|.         ..||
Mouse   212 TNPPQVATYHRAIKVTVDGPREPRRHRQKLDDSKPSLFSDRLSDLGRIPHPSMRVGVPPQNPRPS 276

  Fly   243 ----PGAFNP-----------FMLNPAW-LDAAYMTYGYADYFRHQAAAQAAQVHHPALAKSSAS 291
                |..|||           ...:|.| .|.:|.:|                     |::.::.
Mouse   277 LNSAPSPFNPQGQSQITDPRQAQSSPPWSYDQSYPSY---------------------LSQMTSP 320

  Fly   292 SV-SPNPNPSVATSSSSAVQ--PSEYPHPAAAVAAAAGQPAAM-MPSPPGAAPATPYAIP-QFPF 351
            |: |..|..|...:...|:.  |........|.:.....|::: ..|..||:...|::.| |||
Mouse   321 SIHSTTPLSSTRGTGLPAITDVPRRISDDDTATSDFCLWPSSLSKKSQAGASELGPFSDPRQFP- 384

  Fly   352 NHVAAAAAAKAATPHAFHPYNFA----AAAGLR-ARNAALHHQSEPVHVSPASSRPSSSSPTQQH 411
             .:::...::.:.|...:|..|.    ..:|:. ..:|..|:.:......|.||: |.|.|.|
Mouse   385 -SISSLTESRFSNPRMHYPATFTYTPPVTSGMSLGMSATTHYHTYLPPPYPGSSQ-SQSGPFQ-- 445

  Fly   412 VLLKLNTSIETSSIHEQSASDGDSDDEQIDVVKSEFDLDKSLDVAPLRM--RCDL--KAPSAMKP 472
                  || .|..::..::|           ...:|.:....|.:|.||  .|..  ...:.:.|
Mouse   446 ------TS-STPYLYYGTSS-----------ASYQFPMVPGGDRSPSRMVPPCTTTSNGSTLLNP 492

  Fly   473 LYHESGPGAVAN-SRQPSPETTTKIKSAAVQQKTVWRPY 510
            .......|..|: |...||   |.:.|:....::|||||
Mouse   493 NLPNQNDGVDADGSHSSSP---TVLNSSGRMDESVWRPY 528

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
run	NP_523424.2	Runt	107..235	CDD:459963	84/135 (62%)
Runx2	NP_033950.2	Runt	109..237	CDD:459963	88/189 (47%)
		Herpes_BLLF1	<273..488	CDD:282904	49/258 (19%)
		RunxI	437..528	CDD:430037	26/114 (23%)