Protein Alignment Cyp6v1 and CYP4F2

DIOPT Version :10

• Sequence 1: NP_608403.1
• Gene: Cyp6v1 / 33056
• FlyBaseID: FBgn0031126
• Length: 520
• Species: Drosophila melanogaster
• Sequence 2: NP_001073.3
• Gene: CYP4F2 / 8529
• HGNCID: 2645
• Length: 520
• Species: Homo sapiens
• Alignment Length: 569
• Identity: 143/569 - (25%)
• Similarity: 240/569 - (42%)
• Gaps: 127/569 - (22%)

  Fly     7 ILLAIVTILTGVFIWSRRTYVYWQR-RRVK-FVQPTH---LLGNLSRVLRLEESFAL--QLRRFY 64
            :|:....:|..|..|   ||.::.. ||:: |.||..   ..|:...|...||...:  ||...|
Human    23 LLVGASWLLAHVLAW---TYAFYDNCRRLRCFPQPPRRNWFWGHQGMVNPTEEGMRVLTQLVATY 84

  Fly    65 FDERFR--NEPVVGIYLFHQPALLIRDLQLVRTVLVED---------FVSFSNRFAKCDGRSDKM 118
             .:.|:  ..|:       .|.|.:....::|:|:...         |.||...:.. ||
Human    85 -PQGFKVWMGPI-------SPLLSLCHPDIIRSVINASAAIAPKDKFFYSFLEPWLG-DG----- 135

  Fly   119 GALSLFLAKQPEWREIRTRLAPAFAGAKLKQMFSLMEEIGCDLEWYLKRLTRDLRRGDAERGAIV 183
                |.|:...:|...|..|.|||       .|::::.       |:|.....:....|:...:.
Human   136 ----LLLSAGDKWSRHRRMLTPAF-------HFNILKP-------YMKIFNESVNIMHAKWQLLA 182

  Fly   184 SIKDVCDLYNTDMIASIAFGLRSYSLRNTQSEIGSHCQDLFRPNVRRIIDLF---------VIFY 239
            |....|    .||...|:. :...||:.......||||:.....:..|::|.         ::.:
Human   183 SEGSAC----LDMFEHISL-MTLDSLQKCVFSFDSHCQEKPSEYIAAILELSALVSKRHHEILLH 242

  Fly   240 LPKLVPLLRPKLFTEPHAEFLRRVIQL-------VIEERER-----GGD---------LRNDLIE 283
            :..|       .:..|..:..||..:|       ||:||.|     |.|         ...|.|:
Human   243 IDFL-------YYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQAKAKSKTLDFID 300

  Fly   284 MLLTLKKEADLQQ--DKSHFTHHRDFLAAQAASFEVAGIETCSASMSFALYELAKQPLMQSRLRR 346
            :|| |.|:.|.::  |:.        :.|:|.:|...|.:|.::.:|:.||.|||.|..|.|.|:
Human   301 VLL-LSKDEDGKKLSDED--------IRAEADTFMFEGHDTTASGLSWVLYHLAKHPEYQERCRQ 356

  Fly   347 EIREAFASNPNGRLTYEAVARMEFLDMVVEETLRKYPIVPLLERECT-----PINKKRFYSLRPH 406
            |::|.........:.::.:|.:.||.|.::|:||.:|.||::.|..|     |..:
Human   357 EVQELLKDREPKEIEWDDLAHLPFLTMCMKESLRLHPPVPVISRHVTQDIVLPDGR--------- 412

  Fly   407 AECYTRRGMPVFISNLAIHHDPKYWPDPDRFDPERFSAANKALQAPMSYMPFGAGPRNCIGMQIG 471
               ...:|:...||....||:|..||||:.:||.||...|...::|::::||.||||||||....
Human   413 ---VIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPENIKERSPLAFIPFSAGPRNCIGQTFA 474

  Fly   472 LLQIKLGLVYFLHQHRVEICDRTVERIQFDAKFALLASEQRIYLKVDCL 520
            :.::|:.|...|.:.|| :.|.|..|.:.:   .:|.:|..::|:|:.|
Human   475 MAEMKVVLALTLLRFRV-LPDHTEPRRKPE---LVLRAEGGLWLRVEPL 519

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6v1	NP_608403.1	CYP6-like	70..514	CDD:410679	121/491 (25%)
CYP4F2	NP_001073.3	CYP4F	74..515	CDD:410772	125/509 (25%)