Protein Alignment Cyp6v1 and CYP4F11

DIOPT Version :10

• Sequence 1: NP_608403.1
• Gene: Cyp6v1 / 33056
• FlyBaseID: FBgn0031126
• Length: 520
• Species: Drosophila melanogaster
• Sequence 2: NP_067010.3
• Gene: CYP4F11 / 57834
• HGNCID: 13265
• Length: 524
• Species: Homo sapiens
• Alignment Length: 570
• Identity: 146/570 - (25%)
• Similarity: 244/570 - (42%)
• Gaps: 126/570 - (22%)

  Fly     7 ILLAIV---TILTGVFIWSRRTYVYWQ--RRRVKFVQP---THLLGNLSRVLRLEESF--ALQLR 61
            :||.:|   .:|..|..|   ||.::.  ||...|.||   ....|:...|...||..  ..||.
Human    20 LLLLLVGGSWLLARVLAW---TYTFYDNCRRLQCFPQPPKQNWFWGHQGLVTPTEEGMKTLTQLV 81

  Fly    62 RFYFDERFR--NEPVVGIYLFHQPALLIRDLQLVRTVLVEDFVSFSNRFAK---CDGRSDKMGAL 121
            ..| .:.|:  ..|...:.:...|.::.........|..:|.:.:.  |.|   .||
Human    82 TTY-PQGFKLWLGPTFPLLILCHPDIIRPITSASAAVAPKDMIFYG--FLKPWLGDG-------- 135

  Fly   122 SLFLAKQPEWREIRTRLAPAFAGAKLK---QMFSLMEEIGCDLEWYLKRLTRDLRRGDAERGAIV 183
             |.|:...:|...|..|.|||....||   ::|:....|..| :|  :||.       :|..|.:
Human   136 -LLLSGGDKWSRHRRMLTPAFHFNILKPYMKIFNKSVNIMHD-KW--QRLA-------SEGSARL 189

  Fly   184 SIKDVCDLYNTDMIASIAFGLRSYSLRNTQSEIGSHCQDLFRPNVRRIIDL--FV---------- 236
            .:.:...|...|.:....|...            |:||:.....:..|::|  ||
Human   190 DMFEHISLMTLDSLQKCVFSFE------------SNCQEKPSEYIAAILELSAFVEKRNQQILLH 242

  Fly   237 ---IFYLPKLVPLLRPKLFTEPHAEFLRRVIQL-------VIEERE-----RGGD--LRN----- 279
               ::||             .|..:..||...|       ||:||.     :|.|  |:|
Human   243 TDFLYYL-------------TPDGQRFRRACHLVHDFTDAVIQERRCTLPTQGIDDFLKNKAKSK 294

  Fly   280 --DLIEMLLTLKKEADLQQ--DKSHFTHHRDFLAAQAASFEVAGIETCSASMSFALYELAKQPLM 340
              |.|::|| |.|:.|.::  |:.        :.|:|.:|...|.:|.::.:|:.||.|||.|..
Human   295 TLDFIDVLL-LSKDEDGKELSDED--------IRAEADTFMFEGHDTTASGLSWVLYHLAKHPEY 350

  Fly   341 QSRLRREIREAFASNPNGRLTYEAVARMEFLDMVVEETLRKYPIVPLLERECTPINKKRFYSLRP 405
            |.:.|:|::|.........:.::.:|::.||.|.::|:||.:|.||::.|.||    :.|  :.|
Human   351 QEQCRQEVQELLKDREPIEIEWDDLAQLPFLTMCIKESLRLHPPVPVISRCCT----QDF--VLP 409

  Fly   406 HAECYTRRGMPVFISNLAIHHDPKYWPDPDRFDPERFSAANKALQAPMSYMPFGAGPRNCIGMQI 470
            ...... :|:...|:.:.||::|..||||:.:||.||...|...::|::::||.||||||||...
Human   410 DGRVIP-KGIVCLINIIGIHYNPTVWPDPEVYDPFRFDQENIKERSPLAFIPFSAGPRNCIGQAF 473

  Fly   471 GLLQIKLGLVYFLHQHRVEICDRTVERIQFDAKFALLASEQRIYLKVDCL 520
            .:.::|:.|...|...|: :...|..|.:.:   .:|.:|..::|:|:.|
Human   474 AMAEMKVVLALTLLHFRI-LPTHTEPRRKPE---LILRAEGGLWLRVEPL 519

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6v1	NP_608403.1	CYP6-like	70..514	CDD:410679	122/489 (25%)
CYP4F11	NP_067010.3	CYP4F	74..515	CDD:410772	126/507 (25%)