DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6v1 and Cyp3a25

DIOPT Version :9

Sequence 1:	NP_001285499.1	Gene:	Cyp6v1 / 33056	FlyBaseID:	FBgn0031126	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	NP_062766.2	Gene:	Cyp3a25 / 56388	MGIID:	1930638	Length:	503	Species:	Mus musculus

Alignment Length:	537	Identity:	164/537 - (30%)
Similarity:	259/537 - (48%)	Gaps:	88/537 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 IVTILTGVFIWSRRTYVYWQRRRVKFVQPTHLLGNLSRVLRLEESFALQLRRFYFDERFRNE--- 72
            :||.|...:|:...::..:::..:...:|..|||.:..               |:|..::.:
Mouse    15 LVTSLVLFYIYGTYSHGLFKKLGIPGPKPLPLLGTIFN---------------YYDGMWKFDEDC 64

  Fly    73 -----PVVGIYLFHQPALLIRDLQLVRTVLVEDFVS-FSNR-------FAKCDGRSDKMGALSLF 124
                 .:.|.|...||.|.|.|.::::.|||::..| |:||       |.|          .::.
Mouse    65 YKKYGKIWGFYEGPQPILAIMDPEIIKIVLVKECYSVFTNRRFFGPVGFMK----------KAIT 119

  Fly   125 LAKQPEWREIRTRLAPAFAGAKLKQMFSLMEEIGCDLEWYLKRLTRDLRRGDAERGAIVSIKDVC 189
            :::..||:.:||.|:|.|...|||:||.:|.:.| |:      |.|:||| :.|:|..:|:||:.
Mouse   120 ISEDEEWKRLRTLLSPTFTSGKLKEMFPIMRQYG-DI------LVRNLRR-EEEKGEPISMKDIF 176

  Fly   190 DLYNTDMIASIAFGLRSYSLRNTQSEIGSHCQDLFRPNVRRIIDLFV--IFYLPKLVP---LLRP 249
            ..|:.|:|...:||:...||.|.|.......:.:.:   .:|.|.|:  |...|.|.|   :|..
Mouse   177 GAYSMDVITGTSFGVNVDSLNNPQDPFVQKAKKILK---FKIFDPFLLSIILFPFLTPIYEMLNF 238

  Fly   250 KLFTEPHAEFLRRVIQLVIEERERGGDL-RNDLIEMLLTLKKEADLQQDKSHFTHHRDF-LAAQA 312
            .:|......|.::.::.:.:||...... |.|.:::::..:.....:..|:    ..|. :||||
Mouse   239 SIFPRDSMNFFKKFVKRMKKERLASNQKNRVDFLQLMMNTQNSKGQESQKA----LSDLEMAAQA 299

  Fly   313 ASFEVAGIETCSASMSFALYELAKQPLMQSRLRREIREAFASNPN-GRLTYEAVARMEFLDMVVE 376
            ..|...|.:..|.|:|..:||||..|.:|.:|:.||....   || ..:||:|:..||:|||||.
Mouse   300 VIFIFGGYDATSTSISLIMYELATHPDVQKKLQDEIDRTL---PNKAPVTYDALMDMEYLDMVVN 361

  Fly   377 ETLRKYPIVPLLERECTPINKKRFYSLRPHAE---CYTRRGMPVFISNLAIHHDPKYWPDPDRFD 438
            |:||.|||...|||    ::||       ..|   .:..:|..|.|....:|.:|:|||:|..|.
Mouse   362 ESLRLYPIAIRLER----VSKK-------DVEINGVFIPKGTVVMIPIYPLHRNPEYWPEPQEFC 415

  Fly   439 PERFSAANKALQAPMSYMPFGAGPRNCIGMQIGLLQIKLGLVYFLHQHRVEICDRTVERIQFDAK 503
            |||||..||....|..|||||.||||||||:..|:.|||.::..|....|:.|:.|    |...|
Mouse   416 PERFSKENKGNIDPYIYMPFGNGPRNCIGMRFALISIKLAVIGVLQNFTVQPCEET----QIPLK 476

  Fly   504 FA---LLASEQRIYLKV 517
            .:   :...|:.|.|||
Mouse   477 ISREPIFQPEKPIILKV 493

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6v1	NP_001285499.1	p450	59..517	CDD:299894	154/487 (32%)
Cyp3a25	NP_062766.2	p450	39..493	CDD:278495	158/511 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.820