DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6v1 and cyp3c4

DIOPT Version :9

Sequence 1:	NP_001285499.1	Gene:	Cyp6v1 / 33056	FlyBaseID:	FBgn0031126	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	NP_001071016.1	Gene:	cyp3c4 / 558541	ZFINID:	ZDB-GENE-060929-96	Length:	507	Species:	Danio rerio

Alignment Length:	523	Identity:	143/523 - (27%)
Similarity:	252/523 - (48%)	Gaps:	72/523 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 ILLAIVTILTGVFIWSRRTYVYWQRRRVKFVQPTHLLGNLSRVLRLEESFALQLRRFYFDERFRN 71
            :::.::|:|....:|..|.::   :..:...:|...:|.|.       |:|..|..|..:...:.
Zfish    13 LVVLVITLLFIYGVWPHRFFI---KLGIPGPRPWPFVGTLL-------SYAKGLCNFDMECAKKY 67

  Fly    72 EPVVGIYLFHQPALLIRDLQLVRTVLVED-FVSFSNRFAKCDGRSDKMGALS--LFLAKQPEWRE 133
            ..|.|||....|.|::.||::::.|||:: :.:|.||..:..|.:   |..|  :.:.|...|:.
Zfish    68 GKVWGIYDGRLPILMVADLEVIKVVLVKECYSNFINRRKRTTGLA---GPFSDGIIMVKDERWKR 129

  Fly   134 IRTRLAPAFAGAKLKQMFSLMEEIGCDLEWYLKRLTRDLRRGDAERGAIVSIKDVCDLYNTDMIA 198
            :|:.|:|.|...:||::|.:...       :..|..:::::.|.|:.  |.||:|...|:.|:|.
Zfish   130 MRSTLSPYFTSGRLKEIFPIAMT-------HADRFIKNMQKKDPEQP--VKIKEVVAPYSLDVIT 185

  Fly   199 SIAFGLRSYSLRNTQSEIGSHCQDLFRPNVRRIID-------LFVIFYLPKL-VPL--LRPKLFT 253
            |.:|.:...|:.|.        :|.|..||::.|.       |.:|...|.| :||  :...||:
Zfish   186 SSSFSVDIDSINNP--------EDPFVINVKKFIQFNMFNPLLLLILLFPSLAIPLKKMGVTLFS 242

  Fly   254 EPHAEFLRRVIQLVIEERERGGDLRNDLIEMLLTLKKEADLQQDK-------SHFTHHRDFLAAQ 311
            :...:|...|::.:.::..:..:.|.|.::::|..:...|..||.       ...|.|.  :.:|
Zfish   243 KSAMDFFYSVLKKIKDDHNKESEGRVDFLKLMLQNQIPDDQIQDSDTSEQPAKGLTDHE--ILSQ 305

  Fly   312 AASFEVAGIETCSASMSFALYELAKQPLMQSRLRREIREAF-ASNPNGRLTYEAVARMEFLDMVV 375
            :..|.:.|.||.|.:::|.||.||..|....:|..||.:.| ...|   :||:|:.||::|:|.:
Zfish   306 SLVFILGGYETTSTTLTFLLYNLATNPDCLEKLVEEIDKNFPLDTP---ITYDALMRMDYLEMAI 367

  Fly   376 EETLRKYPIVPLLERECTPINKKRFYSLR----PHAECYTRRGMPVFISNLAIHHDPKYWPDPDR 436
            .|::|..|..|.|||     :.|:...:.    |..   |..|:|.::    :.|||..|..|..
Zfish   368 NESMRLLPTAPRLER-----SAKKTVVINGLTIPEG---TLVGIPTYV----LSHDPDIWESPGE 420

  Fly   437 FDPERFSAANKALQAPMSYMPFGAGPRNCIGMQIGLLQIKLGLVYFLHQHRVEICDRTVERIQFD 501
            |.|||||..||:.....:::|||.||||||||:..::.:||.:|..|....||.|..|...::.:
Zfish   421 FRPERFSPENKSEFLQYAFIPFGLGPRNCIGMRYAVMIMKLFVVKLLQNFSVETCKETQIPLEMN 485

  Fly   502 AKF 504
            ..|
Zfish   486 VTF 488

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6v1	NP_001285499.1	p450	59..517	CDD:299894	134/471 (28%)
cyp3c4	NP_001071016.1	p450	38..485	CDD:278495	138/490 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		mtm8426
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.820