DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6v1 and cyp3a65

DIOPT Version :9

Sequence 1:	NP_001285499.1	Gene:	Cyp6v1 / 33056	FlyBaseID:	FBgn0031126	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	NP_001032515.1	Gene:	cyp3a65 / 553969	ZFINID:	ZDB-GENE-050604-1	Length:	517	Species:	Danio rerio

Alignment Length:	553	Identity:	162/553 - (29%)
Similarity:	269/553 - (48%)	Gaps:	90/553 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MVYS--TNILLAIVTILTGVF-IWSRRTYVYWQRRRVKFVQPTHLLGNLSRVLRLEESFALQLRR 62
            |.:|  |..|||.:..|..:: .|..|   |:::..:...:.....|.:   ||.::.|.:
Zfish     1 MFFSAETWTLLAFLAALLVIYGSWPHR---YFKKLGIPGPKAIPFFGTM---LRYKDGFHV---- 55

  Fly    63 FYFD----ERFRNEPVVGIYLFHQPALLIRDLQLVRTVLVEDFVS-FSNRFAKCDGRSDKM-GAL 121
              ||    |::..  :.|||...||.|.|.|..:::|||:::..| |:||      |:.:: |||
Zfish    56 --FDMDCFEKYGR--IWGIYDGRQPVLCIMDQTIIKTVLIKECYSLFTNR------RNFRLNGAL 110

  Fly   122 --SLFLAKQPEWREIRTRLAPAFAGAKLKQMFSLMEEIGCDLEWYLKRLTRDLRRGDAERGAIVS 184
              ::.:|:..:||.||:.|:|:|...:||:||.:|::        ...:..|.....|:||....
Zfish   111 YDAVSIAEDDDWRRIRSVLSPSFTSGRLKEMFGIMKK--------HSHILVDSMGKTAKRGESAD 167

  Fly   185 IKDVCDLYNTDMIASIAFGLRSYSLRNTQSEIGSHCQDLFRPNVRRII--DL-----FVIFYLPK 242
            ||:....|:.|::.|.||.:...||.|.        :|.|..|:::::  ||     .:|.:.|.
Zfish   168 IKEFFGAYSMDVVTSTAFSVDIDSLNNP--------KDPFVTNIKKMLKFDLLNPLFLLIAFFPF 224

  Fly   243 LVPLLRP---KLFTEPHAEFLRRVIQLVIEERER------GGDLRNDLIEMLLT----LKKEADL 294
            :.|:|..   .||.....:|....:|.:..:|:.      ....|.|.:::::.    :|.::|.
Zfish   225 MAPVLEKMDFALFPTSVTDFFYAALQKIKSDRDTKTVAKDNTKKRVDFLQLMVDSQTGVKHKSDG 289

  Fly   295 QQDKSHFTHHRDFLAAQAASFEVAGIETCSASMSFALYELAKQPLMQSRLRREIREAFASNPN-G 358
            :..:...:.|.  :.:|:..|..||.||.|:::||..|.||..|....:|:.||.|.|   || .
Zfish   290 EHTEKGLSDHE--ILSQSMIFIFAGYETSSSTLSFLFYNLATNPETMKKLQEEIDETF---PNQA 349

  Fly   359 RLTYEAVARMEFLDMVVEETLRKYPIVPLLEREC---TPINKKRFYSLRPHAECYTRRGMPVFIS 420
            .:.||.:..|::||..:.|:||.:|:...|||.|   ..||.    .|.|       :.:.|.:.
Zfish   350 PVDYETLMSMDYLDAALSESLRLFPVAARLERVCKKTVEING----LLIP-------KDLVVMVP 403

  Fly   421 NLAIHHDPKYWPDPDRFDPERFSAANKALQAPMSYMPFGAGPRNCIGMQIGLLQIKLGLVYFLHQ 485
            ..|:|.||.||.:|:.|.||||:..||....|..|||||.||||||||:...:.:||.:|..|.:
Zfish   404 TYALHRDPDYWSEPESFKPERFTKGNKESIDPYMYMPFGLGPRNCIGMRFAQVTMKLAIVEILQR 468

  Fly   486 HRVEICDRTVERIQFDAKF-ALLASEQRIYLKV 517
            ..|.:||.|  ::..:..| .||:.:..|.||:
Zfish   469 FDVSVCDET--QVPLELGFNGLLSPKDPIKLKL 499

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6v1	NP_001285499.1	p450	59..517	CDD:299894	147/490 (30%)
cyp3a65	NP_001032515.1	p450	35..499	CDD:278495	151/514 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		mtm8426
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.920