DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6v1 and cyp3c3

DIOPT Version :9

Sequence 1:	NP_001285499.1	Gene:	Cyp6v1 / 33056	FlyBaseID:	FBgn0031126	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	NP_001007401.2	Gene:	cyp3c3 / 492759	ZFINID:	ZDB-GENE-041114-102	Length:	503	Species:	Danio rerio

Alignment Length:	515	Identity:	137/515 - (26%)
Similarity:	242/515 - (46%)	Gaps:	78/515 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 ILLAIVTILTGVFIWSRRTYVYWQRRRVKFVQPTHLLGNLSRVLRLEESFALQLRRFYFDERFRN 71
            ::..::|:|....:|   .:.::::..:...:|....|..   |...:.|      |.||.....
Zfish    13 LVFLVITLLYMYGVW---PHGFFKKLGIPGPRPWPFFGTF---LSYTKGF------FNFDMECAK 65

  Fly    72 E--PVVGIYLFHQPALLIRDLQLVRTVLVED-FVSFSNRFAKCDGRSDKMGALS--LFLAKQPEW 131
            :  .|.|||....|.|::.||::::|::|:: :.:|:||   .:...|..|.|:  :...|...|
Zfish    66 KYGKVWGIYDGRLPILMVTDLEMIKTIMVKECYSTFTNR---REVNVDLAGPLADGISAVKDERW 127

  Fly   132 REIRTRLAPAFAGAKLKQMFSLMEEIGCDLEWYLKRLTRDLRRGDAERGAIVSIKDVCDLYNTDM 196
            :.||..|:|.|...:||::|.:...       :..|..:::::.|.|:.  |.||:|...|:.|:
Zfish   128 KRIRGTLSPYFTSGRLKEIFPIAMT-------HADRFIKNMQKRDHEQP--VKIKEVVAPYSLDV 183

  Fly   197 IASIAFGLRSYSLRNTQSEIGSHCQDLFRPNVRRII--DLF--VIFYL---PKLVPLLRP---KL 251
            :.|.:|.:...|:.|.        .|.|..|::..:  .||  :|.:|   |.:..||..   .:
Zfish   184 VTSSSFSVDIDSINNP--------DDPFVTNIKNFLKFSLFSPLILFLTLFPSIANLLGKMGISV 240

  Fly   252 FTEPHAEFLRRVIQLVIEE-RERGGDLRNDLIEMLLTLK------KEADLQQDKSHFTHHRDFLA 309
            |:.....|....::.:.:| ::..|  |.|.:.:::..:      |:...:|.....|.|.  :.
Zfish   241 FSRSIMNFFYTALRKIKDEHKDSNG--RVDFLRLMIQNQIPDDQAKDTTSEQPVKGLTDHE--IL 301

  Fly   310 AQAASFEVAGIETCSASMSFALYELAKQPLMQSRLRREIREAF-ASNPNGRLTYEAVARMEFLDM 373
            :|:..|.:.|.||.|.::||.|:.||..|....:|..||.:.| ...|   ::|:|:.:|::|:|
Zfish   302 SQSFIFILGGYETTSTTLSFLLHNLATNPDCLEKLVEEIDKNFPLDTP---ISYDALMKMDYLEM 363

  Fly   374 VVEETLRKYPIVPLLERECTPINKKRFYSLR----PHAECYTRRGMPVFISNLAIHHDPKYWPDP 434
            .:.|::|..|..|.|||.|     |:...|.    |..   |...:|.::.|    .||:.|..|
Zfish   364 SINESMRLLPTAPRLERVC-----KKTVELNGITIPKD---TLVAIPTYVLN----RDPQLWDSP 416

  Fly   435 DRFDPERFSAANKALQAPMSYMPFGAGPRNCIGMQIGLLQIKLGLVYFLHQHRVEICDRT 494
            ..|.|||||..||:.....::||||.||||||||:..|:.:||.:|..|....:|.|..|
Zfish   417 QEFRPERFSPENKSEFLQYAFMPFGLGPRNCIGMRFALMIVKLLVVKLLQNFSLETCKET 476

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6v1	NP_001285499.1	p450	59..517	CDD:299894	130/463 (28%)
cyp3c3	NP_001007401.2	p450	38..496	CDD:278495	134/487 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		mtm8426
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.820