DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp6v1 and Cyp6a17

DIOPT Version :9

Sequence 1:	NP_001285499.1	Gene:	Cyp6v1 / 33056	FlyBaseID:	FBgn0031126	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	NP_001286433.1	Gene:	Cyp6a17 / 45556	FlyBaseID:	FBgn0015714	Length:	501	Species:	Drosophila melanogaster

Alignment Length:	525	Identity:	167/525 - (31%)
Similarity:	279/525 - (53%)	Gaps:	38/525 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 ILLAIVTILTGVFIW-SRRTYVYWQRRRVKFVQPTHLLGNLS---RVLRLEESFALQLRRFYFDE 67
            :|||::.::..:.:: :||.:.|||||.:...:...|.||:.   ....:.|.|    |.:||..
  Fly     2 LLLALIVVILSLLVFAARRRHGYWQRRGIPHDEVHPLFGNIKDWPNKRHIAEIF----RDYYFKY 62

  Fly    68 RFRNEPVVGIYLFHQPALLIRDLQLVRTVLVEDFVSFSNRFAKCDGRSDKMGALSLFLAKQPEWR 132
            :..:.|..|.:.|.....::.|::|::.||::||..|.||....:...|.:.| :||..:..:||
  Fly    63 KNSDYPFAGFFFFFTRTAVVTDMELLKRVLIKDFNHFENRGVFYNEIDDPLSA-TLFSIEGQKWR 126

  Fly   133 EIRTRLAPAFAGAKLKQMFSLMEEIGCDLEWYLKRLTRDLRRGDAERGAIVSIKDVCDLYNTDMI 197
            .:|.:|.|.|...|:|.||.::.::|.:::...:..|.      |:||.::.:.|:...|..|:|
  Fly   127 HLRHKLTPTFTSGKMKNMFPIVVKVGEEMDKVFRSKTA------ADRGQVLEVVDLVARYTADVI 185

  Fly   198 ASIAFGLRSYSLRNTQSE---IGSHCQDLFRPNVRRIIDLFVIFYLPKLVPLLRPKLFTEPHAEF 259
            .:.||||...||.:.::|   ||...  :.......::|:| :|..|||...||.||..:...:|
  Fly   186 GNCAFGLNCNSLYDPKAEFVSIGKRA--ITEHRYGNMLDIF-LFGFPKLSRRLRLKLNIQEAEDF 247

  Fly   260 LRRVIQLVIEERERGGDLRNDLIEMLLTLKKEADLQQDKSHFTHHRDFLAAQAASFEVAGIETCS 324
            ..::::..|:.|.|..:.|||.::.|:.:.|.......:...|.:.  |.|||..|.|||.||.|
  Fly   248 YTKIVRETIDYRLRTKEKRNDFMDSLIEMYKNEQSGNSEDGLTFNE--LLAQAFIFFVAGFETSS 310

  Fly   325 ASMSFALYELAKQPLMQSRLRREIREAFASNPNGRLTYEAVARMEFLDMVVEETLRKYPIVPLLE 389
            .:|.|||||||:...:|.:||.||...|..: |...|||.:..|::|:.||.|||||||::..|.
  Fly   311 TTMGFALYELARNQDVQDKLREEIGNVFGKH-NKEFTYEGIKEMKYLEQVVMETLRKYPVLAHLT 374

  Fly   390 R----ECTPINKKRFYSLRPHAECYTRRGMPVFISNLAIHHDPKYWPDPDRFDPERFSAANKALQ 450
            |    :.:|.:.|.|.:          :|..|.|..|.||:||..:|:|:.|.||||:....|.:
  Fly   375 RMTDTDFSPEDPKYFIA----------KGTIVVIPALGIHYDPDIYPEPEIFKPERFTDEEIAAR 429

  Fly   451 APMSYMPFGAGPRNCIGMQIGLLQIKLGLVYFLHQHRVEICDRTVERIQFDAKFALLASEQRIYL 515
            ...:::|||.|||||||::.|::|..:||.|.:..::..:...|...::...|..|:::|..|:|
  Fly   430 PSCTWLPFGEGPRNCIGLRFGMMQTCVGLAYLIRGYKFSVSPETQIPMKIVVKNILISAENGIHL 494

  Fly   516 KVDCL 520
            ||:.|
  Fly   495 KVEKL 499

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6v1	NP_001285499.1	p450	59..517	CDD:299894	149/464 (32%)
Cyp6a17	NP_001286433.1	p450	36..478	CDD:278495	149/468 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45461117
Domainoid	1	1.000	151	1.000	Domainoid score	I1386
eggNOG	1	0.900	-	-		E2759_KOG0158
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	161	1.000	Inparanoid score	I1621
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		otm3438
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
	10	9.900