Protein Alignment Cyp6v1 and CYP4F3

DIOPT Version :10

• Sequence 1: NP_608403.1
• Gene: Cyp6v1 / 33056
• FlyBaseID: FBgn0031126
• Length: 520
• Species: Drosophila melanogaster
• Sequence 2: NP_000887.2
• Gene: CYP4F3 / 4051
• HGNCID: 2646
• Length: 520
• Species: Homo sapiens
• Alignment Length: 581
• Identity: 145/581 - (24%)
• Similarity: 236/581 - (40%)
• Gaps: 136/581 - (23%)

  Fly     1 MVYSTNILLAIV---TILTGVFIWSRRTYVYWQR--RRVKFVQP---THLLGNLSRVLRLEES-- 55
            |..|..:||.:|   .:|..:..|   ||.::..  |...|.||   ...||:|..:...||.
Human    14 MAASPWLLLLLVGASWLLARILAW---TYTFYDNCCRLRCFPQPPKRNWFLGHLGLIHSSEEGLL 75

  Fly    56 FALQLRRFYFD------------ERFRNEPVVGIYLFHQPALLIRDLQLVRTVLVEDFVSFSNRF 108
            :...|...:.|            .|..:...:...||...|::.:|         :.|.||...:
Human    76 YTQSLACTFGDMCCWWVGPWHAIVRIFHPTYIKPVLFAPAAIVPKD---------KVFYSFLKPW 131

  Fly   109 AKCDGRSDKMGALSLFLAKQPEWREIRTRLAPAFAGAKLKQMFSLMEEIG--CDLEWYLKRLTRD 171
            .. ||         |.|:...:|...|..|.|||....||....:..|..  ...:|.|..
Human   132 LG-DG---------LLLSAGEKWSRHRRMLTPAFHFNILKPYMKIFNESVNIMHAKWQLLA---- 182

  Fly   172 LRRGDAERGAIVSIKDVCDLYNTDMIASIAFGLRSYSLRNTQSEIGSHCQDLFRPNVRRIIDLF- 235
                 :|..|.:.:.:...|...|.:....|            ...||||:.....:..|::|.
Human   183 -----SEGSARLDMFEHISLMTLDSLQKCVF------------SFDSHCQEKPSEYIAAILELSA 230

  Fly   236 --------VIFYLPKLVPLLRPKLFTEPHAEFLRRVIQL-------VIEERER-----GGD---- 276
                    ::.|:..|       .:..|..:..||..:|       ||:||.|     |.|
Human   231 LVTKRHQQILLYIDFL-------YYLTPDGQRFRRACRLVHDFTDAVIQERRRTLPSQGVDDFLQ 288

  Fly   277 -----LRNDLIEMLLTLKKEADLQQ--DKSHFTHHRDFLAAQAASFEVAGIETCSASMSFALYEL 334
                 ...|.|::|| |.|:.|.::  |:.        :.|:|.:|...|.:|.::.:|:.||.|
Human   289 AKAKSKTLDFIDVLL-LSKDEDGKKLSDED--------IRAEADTFMFEGHDTTASGLSWVLYHL 344

  Fly   335 AKQPLMQSRLRREIREAFASNPNGRLTYEAVARMEFLDMVVEETLRKYPIVPLLERECT-----P 394
            ||.|..|.|.|:|::|.........:.::.:|::.||.|.::|:||.:|.||.:.|.||     |
Human   345 AKHPEYQERCRQEVQELLKDREPKEIEWDDLAQLPFLTMCIKESLRLHPPVPAVSRCCTQDIVLP 409

  Fly   395 INKKRFYSLRPHAECYTRRGMPVFISNLAIHHDPKYWPDPDRFDPERFSAANKALQAPMSYMPFG 459
            ..:            ...:|:...||....||:|..||||:.:||.||...|...::|::::||.
Human   410 DGR------------VIPKGIICLISVFGTHHNPAVWPDPEVYDPFRFDPKNIKERSPLAFIPFS 462

  Fly   460 AGPRNCIGMQIGLLQIKLGLVYFLHQHRVEICDRTVERIQFDAKFALLASEQRIYLKVDCL 520
            ||||||||....:.::|:.|...|.:.|| :.|.|..|.:.:   .:|.:|..::|:|:.|
Human   463 AGPRNCIGQAFAMAEMKVVLGLTLLRFRV-LPDHTEPRRKPE---LVLRAEGGLWLRVEPL 519

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6v1	NP_608403.1	CYP6-like	70..514	CDD:410679	121/482 (25%)
CYP4F3	NP_000887.2	CYP4F	74..515	CDD:410772	124/512 (24%)