DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6v1 and Cyp6a9

DIOPT Version :9

Sequence 1:	NP_001285499.1	Gene:	Cyp6v1 / 33056	FlyBaseID:	FBgn0031126	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	NP_523748.2	Gene:	Cyp6a9 / 36663	FlyBaseID:	FBgn0013771	Length:	504	Species:	Drosophila melanogaster

Alignment Length:	531	Identity:	171/531 - (32%)
Similarity:	279/531 - (52%)	Gaps:	45/531 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 VYSTNILLAIVTILTGVFI--WSRRTYVYWQRRRVKFVQPTHLLGNLSRVLRLEESFALQLRRFY 64
            |||  :|||||.:|.|..:  | ||...|||...:...:|..|:|:|:.| :...||:.....:|
  Fly     3 VYS--VLLAIVVVLVGYLLLKW-RRALHYWQNLDIPCEEPHILMGSLTGV-QTSRSFSAIWMDYY 63

  Fly    65 FDERFRNE-PVVGIYLFHQPALLIRDLQLVRTVLVEDFVSFSNRFAKCDGRSDKMGALSLFLAKQ 128
              .:||.. |..|.|.|.:|.:|:.|:.|.:.:|:::|..|::|....:...|.:.. .|||...
  Fly    64 --NKFRGTGPFAGFYWFQRPGILVLDISLAKLILIKEFNKFTDRGFYHNTEDDPLSG-QLFLLDG 125

  Fly   129 PEWREIRTRLAPAFAGAKLKQMFSLMEEIGCD-LEWYLKRLTRDLRRGDA-ERGAIVSIKDVCDL 191
            .:|:.:|::|:..|...|:|.||..:.::|.: :|.:          |.| |:..||.::|:...
  Fly   126 QKWKSMRSKLSYTFTSGKMKYMFPTVVKVGHEFIEVF----------GQAMEKSPIVEVRDILAR 180

  Fly   192 YNTDMIASIAFGLRSYSLRNTQSEIGSHCQDLFRPNVRRI--------IDLFVIFYLPKLVPLLR 248
            :.||:|.:.|||:...||::.::|        ||...||.        |.:..|.....|...|.
  Fly   181 FTTDVIGTCAFGIECSSLKDPEAE--------FRVMGRRAIFEQRHGPIGIAFINSFQNLARRLH 237

  Fly   249 PKLFTEPHAEFLRRVIQLVIEERERGGDLRNDLIEMLLTLKKEADLQQDKSHFTHHR-DFLAAQA 312
            .|:..|....|..|:::..:..||:....|||.::.|:.||.....:.:.....:.. :.:||||
  Fly   238 MKITLEEAEHFFLRIVRETVAFREKNNIRRNDFMDQLIDLKNSPLTKSESGESVNLTIEEMAAQA 302

  Fly   313 ASFEVAGIETCSASMSFALYELAKQPLMQSRLRREIREAFASNPNGRLTYEAVARMEFLDMVVEE 377
            ..|..||.||.|.:|.|||||||:...:|.|:|:|.:|..... ||.:|||::..|.:||.|:.|
  Fly   303 FVFFGAGFETSSTTMGFALYELAQHQDIQDRVRKECQEVIGKY-NGEITYESMKDMVYLDQVISE 366

  Fly   378 TLRKYPIVPLLERECTPINKKRFYSLRPHAECYTRRGMPVFISNLAIHHDPKYWPDPDRFDPERF 442
            |||.|.::|:|.|||.     ..|.:..|.:...::||||.|...|:|.|.|.:.:|:.|:|:.|
  Fly   367 TLRLYTVLPVLNRECL-----EDYEVPGHPKYVIKKGMPVLIPCGAMHRDEKLYANPNTFNPDNF 426

  Fly   443 SAANKALQAPMSYMPFGAGPRNCIGMQIGLLQIKLGLVYFLHQHRVEICDRTVERIQFDAKFALL 507
            |......:..:.::|||.||||||||:.|.:|.:.||...:::.:..:|::|...|.:..|..|:
  Fly   427 SPERVKERDSVEWLPFGDGPRNCIGMRFGQMQARSGLALLINRFKFSVCEQTTIPIVYSKKTFLI 491

  Fly   508 ASEQRIYLKVD 518
            :||..|:|||:
  Fly   492 SSETGIFLKVE 502

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6v1	NP_001285499.1	p450	59..517	CDD:299894	146/469 (31%)
Cyp6a9	NP_523748.2	p450	35..499	CDD:278495	152/491 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45461112
Domainoid	1	1.000	151	1.000	Domainoid score	I1386
eggNOG	1	0.900	-	-		E2759_KOG0158
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	161	1.000	Inparanoid score	I1621
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		otm3438
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
	10	9.900