DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp6v1 and Cyp6t3

DIOPT Version :9

Sequence 1:	NP_001285499.1	Gene:	Cyp6v1 / 33056	FlyBaseID:	FBgn0031126	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	NP_610745.1	Gene:	Cyp6t3 / 36318	FlyBaseID:	FBgn0033697	Length:	501	Species:	Drosophila melanogaster

Alignment Length:	515	Identity:	207/515 - (40%)
Similarity:	304/515 - (59%)	Gaps:	28/515 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 ILLAIVTILTGVFIWSRRTYVYWQRRRVKFVQPTHL--LGNLSRVLRLEESFALQLRRFYFDERF 69
            |.|.::||:|..| |.|..|.|::.|.:..:.|:..  :|||.::|.|..||....|:.|.|.|.
  Fly     4 IWLLLLTIVTLNF-WLRHKYDYFRSRGIPHLPPSSWSPMGNLGQLLFLRISFGDLFRQLYADPRN 67

  Fly    70 RNEPVVGIYLFHQPALLIRDLQLVRTVLVEDFVSFSNRFAKCDGRSDKMGALSLFLAKQPEWREI 134
            ....:||.::|..|||::||.:|:|.||:::|.:|.|||...|. .|.||||:|.|||...|:|.
  Fly    68 GQAKIVGFFIFQTPALMVRDPELIRQVLIKNFNNFLNRFESADA-GDPMGALTLPLAKYHHWKES 131

  Fly   135 RTRLAPAFAGAKLKQ-MFSLMEEIGCDLEWYLKRLTRDLRRGD-AERGAIVSIKDVCDLYNTDMI 197
            |..::..|...:::. |:|.|.::..|||.||.|     :.|| .||  ::.:..:|.||.||:.
  Fly   132 RQCMSQLFTSGRMRDVMYSQMLDVASDLEQYLNR-----KLGDRLER--VLPLGRMCQLYTTDVT 189

  Fly   198 ASIAFGLRSYSLRNTQSEIGSHCQDLFRPNVRRIIDLFVIFYLPKLVPLLRPKLFTEPHAEFLRR 262
            .::.:.|....||..:||:.:..::||..|.|:::|...:|:|||...:|:||:|||.:|.::|
  Fly   190 GNLFYSLNVGGLRRGRSELITKTKELFNTNPRKVLDFMSVFFLPKWTGVLKPKVFTEDYARYMR- 253

  Fly   263 VIQLVIEERE-RGGDLRNDLIEMLLTLKKEADLQQDKSHFTHHRDFLAAQAASFEVAGIETCSAS 326
              .||.:..| ..|||.|.|        :...|.:..:|::.|.||:|:||....:||.||.||.
  Fly   254 --HLVDDHHEPTKGDLINQL--------QHFQLSRSSNHYSQHPDFVASQAGIILLAGFETSSAL 308

  Fly   327 MSFALYELAKQPLMQSRLRREIREAFASNPNGRLTYEAVARMEFLDMVVEETLRKYPIVPLLERE 391
            |.|.||||||.|.:|.|||.|:||||.|  ...|:|:.:..:.:|.||..|.||.||....:.||
  Fly   309 MGFTLYELAKAPDIQERLRSELREAFIS--TATLSYDTLMTLPYLKMVCLEALRLYPAAAFVNRE 371

  Fly   392 CTPINKKRFYSLRPHAECYTRRGMPVFISNLAIHHDPKYWPDPDRFDPERFSAANKALQAPMSYM 456
            ||....:.| ||:||.:.....|||.:||.|.:|.|.::||:|..||||||.........||:|:
  Fly   372 CTSSASEGF-SLQPHVDFIVPPGMPAYISILGLHRDERFWPEPCVFDPERFGPERSRHIHPMTYI 435

  Fly   457 PFGAGPRNCIGMQIGLLQIKLGLVYFLHQHRVEICDRTVERIQFDAKFALLASEQRIYLK 516
            ||||||..|||.::|:||:|||:|:.|.|:.||.|:|||..|:|:.|..:|.||..|||:
  Fly   436 PFGAGPHGCIGSRLGVLQLKLGIVHILKQYWVETCERTVSEIRFNPKSFMLESENEIYLR 495

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6v1	NP_001285499.1	p450	59..517	CDD:299894	188/461 (41%)
Cyp6t3	NP_610745.1	p450	34..486	CDD:299894	190/473 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45450332
Domainoid	1	1.000	151	1.000	Domainoid score	I1386
eggNOG	1	0.900	-	-		E2759_KOG0158
Homologene	1	1.000	-	-		H59722
Inparanoid	1	1.050	161	1.000	Inparanoid score	I1621
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		otm3438
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
	11	10.900