DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp6v1 and Cyp6a13

DIOPT Version :9

Sequence 1:	NP_001285499.1	Gene:	Cyp6v1 / 33056	FlyBaseID:	FBgn0031126	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	NP_610390.1	Gene:	Cyp6a13 / 35837	FlyBaseID:	FBgn0033304	Length:	493	Species:	Drosophila melanogaster

Alignment Length:	515	Identity:	179/515 - (34%)
Similarity:	282/515 - (54%)	Gaps:	29/515 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 ILLAIVTILTGVFIWSRRTYVYWQRRRVKFVQPTHLLGNLSRVLRLEESFALQLRRFYFDERFRN 71
            :|:.:.|:...:::..|..|.||.||.|...:|.:..||:|.:.|......:.||.:   .:||.
  Fly     4 LLVLVFTVGLLLYVKLRWHYSYWSRRGVAGERPVYFRGNMSGLGRDLHWTDINLRIY---RKFRG 65

  Fly    72 -EPVVGIYLFHQPALLIRDLQLVRTVLVEDFVSFSNRFAKCDGRSDKMGALSLFLAKQPEWREIR 135
             |...|.:.|...:|.|.||:|:|.:::.||.||::|....:.|.|.:....||| ..||||.:|
  Fly    66 VERYCGYFTFMTKSLFIMDLELIRDIMIRDFSSFADRGLFHNVRDDPLTGNLLFL-DGPEWRWLR 129

  Fly   136 TRLAPAFAGAKLKQMFSLMEEIGCDLEWYLKRLTRDLRRGDAERGAIVSIKDVCDLYNTDMIASI 200
            ..|...|...|:|.||..|.|:|       ::||:..|....|    :..||:|..:.||:|.|.
  Fly   130 QNLTQVFTSGKMKFMFPNMVEVG-------EKLTQACRLQVGE----IEAKDLCARFTTDVIGSC 183

  Fly   201 AFGLRSYSLRNTQSEIGSHCQDLFRPNVRRIIDLFVIFYLPKLVPLLRPKLFTEPHAEFLRRVIQ 265
            ||||...||::.:|:.....:.:.:..:..::....:|..|:|...||.:||....:||....::
  Fly   184 AFGLECNSLQDPESQFRRMGRSVTQEPLHSVLVQAFMFAQPELARKLRFRLFRPEVSEFFLDTVR 248

  Fly   266 LVIEERERGGDLRNDLIEMLLTLKKEADLQQDKSHFTHHRDFLAAQAASFEVAGIETCSASMSFA 330
            ..::.|.|....|||||::|:.|.:|.  .:|...|    :.:||||..|.:||.:|.|.:|||.
  Fly   249 QTLDYRRRENIHRNDLIQLLMELGEEG--VKDALSF----EQIAAQALVFFLAGFDTSSTTMSFC 307

  Fly   331 LYELAKQPLMQSRLRREIREAFASNPNGRLTYEAVARMEFLDMVVEETLRKYPIVPLLERECTPI 395
            |||||..|.:|.|||.|:......| |.:|||::|..|.:||.||.||||||||:|.|.|..|
  Fly   308 LYELALNPDVQERLRVEVLAVLKRN-NQKLTYDSVQEMPYLDQVVAETLRKYPILPHLLRRST-- 369

  Fly   396 NKKRFYSLRPHAECYTRRGMPVFISNLAIHHDPKYWPDPDRFDPERFSAANKALQAPMSYMPFGA 460
               :.|.: |::......|..:.|...:|||||:.:|||::|||.||.......:.|.:|:|||.
  Fly   370 ---KEYQI-PNSNLILEPGSKIIIPVHSIHHDPELYPDPEKFDPSRFEPEEIKARHPFAYLPFGE 430

  Fly   461 GPRNCIGMQIGLLQIKLGLVYFLHQHRVEICDRTVERIQFDAKFALLASEQRIYLKVDCL 520
            |||||||.:.|.||:|:||||.|...:....::|...::|.::..|:::::.::|:::.|
  Fly   431 GPRNCIGERFGKLQVKVGLVYLLRDFKFSRSEKTQIPLKFSSRNFLISTQEGVHLRMEGL 490

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6v1	NP_001285499.1	p450	59..517	CDD:299894	164/458 (36%)
Cyp6a13	NP_610390.1	p450	33..476	CDD:278495	167/470 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45461120
Domainoid	1	1.000	151	1.000	Domainoid score	I1386
eggNOG	1	0.900	-	-		E2759_KOG0158
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	161	1.000	Inparanoid score	I1621
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		mtm8426
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
	10	9.900