DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6v1 and Cyp6a14

DIOPT Version :9

Sequence 1:	NP_001285499.1	Gene:	Cyp6v1 / 33056	FlyBaseID:	FBgn0031126	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	NP_001286199.1	Gene:	Cyp6a14 / 35835	FlyBaseID:	FBgn0033302	Length:	509	Species:	Drosophila melanogaster

Alignment Length:	529	Identity:	184/529 - (34%)
Similarity:	290/529 - (54%)	Gaps:	45/529 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LAIVTILTGV-FIWSRRTYVYWQRRRVKFVQPTHLLGNLSRVLRLEESFALQLRRFYFDERFRNE 72
            :|:|.::.|: :....:.:.||:|:.|....|..::||:..::: :..|....:|.|  ::|:.:
  Fly     5 IALVGVVLGLAYSLHIKIFSYWKRKGVPHETPLPIVGNMRGIVK-KYHFRDINQRIY--KKFKGQ 66

  Fly    73 -PVVGIYLFHQPALLIRDLQLVRTVLVEDFVSFSNRFAKCDGRSDKMGALSLFLAKQPEWREIRT 136
             |:.|:|:|.:...||.||..::.|:::||..|.:|.|..:.|.|.:.. .||..:..|||.:|.
  Fly    67 GPIAGMYMFFKRTALITDLDFIKQVMIKDFSYFQDRGAFTNPRDDPLTG-HLFALEGEEWRAMRH 130

  Fly   137 RLAPAFAGAKLKQMFSLMEEIGCDLEWYLKRLTRDLRRGDAERGAI---------VSIKDVCDLY 192
            :|.|.|...|:|||..::.::|             ||.|||...|:         |.|||:|..:
  Fly   131 KLTPVFTSGKIKQMSKVIVDVG-------------LRLGDAMDKAVKEAKVEEGNVEIKDLCARF 182

  Fly   193 NTDMIASIAFGLRSYSLRNTQSEIGSHCQDLF-RPNVRRIIDLFVIFYLPKLVPLLRPKLFTEPH 256
            .||:|.|.||||...||::..:|.....:::| |.....::..| ||...:|...||.|:..:..
  Fly   183 TTDVIGSCAFGLECNSLQDPSAEFRQKGREIFTRRRHSTLVQSF-IFTNARLARKLRIKVLPDDL 246

  Fly   257 AEFLRRVIQLVIEERERGGDLRNDLIEMLLTLKKE----ADLQQ--DKSH-FTHHRDFLAAQAAS 314
            .:|....::..::.|.:.|..|||.||.::.|:.|    |...|  |.|| .|..:  :||||..
  Fly   247 TQFFMSTVKNTVDYRLKNGIKRNDFIEQMIELRAEDQEAAKKGQGIDLSHGLTLEQ--MAAQAFV 309

  Fly   315 FEVAGIETCSASMSFALYELAKQPLMQSRLRREIREAFASNPNGRLTYEAVARMEFLDMVVEETL 379
            |.|||.||.|::||..|||||.||.:|.|||.||....|:...|.|.|:.:|:|.:||.|:.|||
  Fly   310 FFVAGFETSSSTMSLCLYELALQPDIQQRLREEIESVLANVDGGELNYDVLAQMTYLDQVLSETL 374

  Fly   380 RKYPIVPLLERECTPINKKRFYSLRPHAECYTRRGMPVFISNLAIHHDPKYWPDPDRFDPERFSA 444
            ||:|::|.|.||.|     :.|.: |:::....:|:...|....|||||:.:|:|::|||.||..
  Fly   375 RKHPLLPHLIRETT-----KDYQI-PNSDIVLDKGILALIPVHNIHHDPEIYPEPEKFDPSRFDP 433

  Fly   445 ANKALQAPMSYMPFGAGPRNCIGMQIGLLQIKLGLVYFLHQHRVEICDRTVERIQFDAKFALLAS 509
            .....:.||:|:|||.|||||||::.|.:|.|:|||..|.:.:..:.:||...:.|..|..||.:
  Fly   434 EEVKNRHPMAYLPFGDGPRNCIGLRFGKIQAKIGLVSLLRRFKFSVSNRTDVPLIFSKKSFLLTT 498

  Fly   510 EQRIYLKVD 518
            ...|||||:
  Fly   499 NDGIYLKVE 507

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6v1	NP_001285499.1	p450	59..517	CDD:299894	171/475 (36%)
Cyp6a14	NP_001286199.1	p450	32..506	CDD:306555	175/499 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	151	1.000	Domainoid score	I1386
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	161	1.000	Inparanoid score	I1621
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		mtm8426
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
	8	8.070