DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6v1 and Cyp6a2

DIOPT Version :9

Sequence 1:	NP_001285499.1	Gene:	Cyp6v1 / 33056	FlyBaseID:	FBgn0031126	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	NP_523628.1	Gene:	Cyp6a2 / 35587	FlyBaseID:	FBgn0000473	Length:	506	Species:	Drosophila melanogaster

Alignment Length:	531	Identity:	180/531 - (33%)
Similarity:	287/531 - (54%)	Gaps:	43/531 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MVYSTNILLAIVTILTGVFIWSRRTYVYWQRRRVKFVQPTHLLGNL-----SRVLRLEESFALQL 60
            ::|   :|:||.::|..::   .|.:.||.||.|....|..|.||:     :||          :
  Fly     4 LIY---LLIAISSLLAYLY---HRNFNYWNRRGVPHDAPHPLYGNMVGFRKNRV----------M 52

  Fly    61 RRFYFD--ERFRNE--PVVGIYLFHQPALLIRDLQLVRTVLVEDFVSFSNRFAKCDGRSDKMGAL 121
            ..|::|  .::|..  |.||.|..|:||..|.|.||.:.:|::||.:|::|....:||.|.: ..
  Fly    53 HDFFYDYYNKYRKSGFPFVGFYFLHKPAAFIVDTQLAKNILIKDFSNFADRGQFHNGRDDPL-TQ 116

  Fly   122 SLFLAKQPEWREIRTRLAPAFAGAKLKQMFSLMEEIGCDLEWYLKRLTRDLRRGDAERGAIVSIK 186
            .||.....:|:::|.||.|.|...|:|.||..:.::.   |.::|.:|..:..  |:.||::.||
  Fly   117 HLFNLDGKKWKDMRQRLTPTFTSGKMKFMFPTVIKVS---EEFVKVITEQVPA--AQNGAVLEIK 176

  Fly   187 DVCDLYNTDMIASIAFGLRSYSLRNTQSEIGSHCQDLFRPNVR--RIIDLFVIFYLPKLVPLLRP 249
            ::...:.||:|.:.|||:...:||...|:..:..|.:| .::|  :::.:|| |..|||...||.
  Fly   177 ELMARFTTDVIGTCAFGIECNTLRTPVSDFRTMGQKVF-TDMRHGKLLTMFV-FSFPKLASRLRM 239

  Fly   250 KLFTEPHAEFLRRVIQLVIEERERGGDLRNDLIEMLLTLKKEADLQQDKSHFTHHRDF--LAAQA 312
            ::..|...:|..|::...|..|||....|||.:.:|:.||::..:..|........|.  ||||.
  Fly   240 RMMPEDVHQFFMRLVNDTIALRERENFKRNDFMNLLIELKQKGRVTLDNGEVIEGMDIGELAAQV 304

  Fly   313 ASFEVAGIETCSASMSFALYELAKQPLMQSRLRREIREAFASNPNGRLTYEAVARMEFLDMVVEE 377
            ..|.|||.||.|::||:.|||||:...:|.|||.|| :.......|:||||::..|.:|:.|:.|
  Fly   305 FVFYVAGFETSSSTMSYCLYELAQNQDIQDRLRNEI-QTVLEEQEGQLTYESIKAMTYLNQVISE 368

  Fly   378 TLRKYPIVPLLERECTPINKKRFYSLRPHAECYTRRGMPVFISNLAIHHDPKYWPDPDRFDPERF 442
            |||.|.:||.|||:.  :|.   |.:..|.:....:|..|.|...|.|.|...:|:|:.||||||
  Fly   369 TLRLYTLVPHLERKA--LND---YVVPGHEKLVIEKGTQVIIPACAYHRDEDLYPNPETFDPERF 428

  Fly   443 SAANKALQAPMSYMPFGAGPRNCIGMQIGLLQIKLGLVYFLHQHRVEICDRTVERIQFDAKFALL 507
            |....|.:..:.::|||.||||||||:.|.:|.::||...:.:.||.:||.|...:::.....:|
  Fly   429 SPEKVAARESVEWLPFGDGPRNCIGMRFGQMQARIGLAQIISRFRVSVCDTTEIPLKYSPMSIVL 493

  Fly   508 ASEQRIYLKVD 518
            .:...|||:|:
  Fly   494 GTVGGIYLRVE 504

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6v1	NP_001285499.1	p450	59..517	CDD:299894	162/465 (35%)
Cyp6a2	NP_523628.1	p450	36..502	CDD:278495	167/489 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45461113
Domainoid	1	1.000	151	1.000	Domainoid score	I1386
eggNOG	1	0.900	-	-		E2759_KOG0158
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	161	1.000	Inparanoid score	I1621
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		otm3438
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
	10	9.900