DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6v1 and Cyp3a44

DIOPT Version :9

Sequence 1:	NP_001285499.1	Gene:	Cyp6v1 / 33056	FlyBaseID:	FBgn0031126	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	NP_796354.1	Gene:	Cyp3a44 / 337924	MGIID:	2449818	Length:	504	Species:	Mus musculus

Alignment Length:	530	Identity:	171/530 - (32%)
Similarity:	265/530 - (50%)	Gaps:	63/530 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 TNILLAIVTILTGVFIWSRRTYVYWQRRRVKFVQPTHLLGNLSRVLRLEESFALQLRRFYFDERF 69
            |.:||||:.:|  ::.:..||:..::::.:...:|...||.:.       ::...:.:|..:...
Mouse    11 TLVLLAIILVL--LYRYGTRTHGLFKKQGIPGPKPLPFLGTVL-------NYYTGIWKFDMECYE 66

  Fly    70 RNEPVVGIYLFHQPALLIRDLQLVRTVLVEDFVS-FSNRFAKCDGRSDKMGALS--LFLAKQPEW 131
            :.....|::....|.|:|.|.:.::.|||:|.:| |:||     .....:|.:|  :.::|..||
Mouse    67 KYGKTWGLFDGQTPLLVITDPETIKNVLVKDCLSVFTNR-----REFGPVGIMSKAISISKDEEW 126

  Fly   132 REIRTRLAPAFAGAKLKQMFSLMEEIGCDLEWYLKRLTRDLRRGDAERGAIVSIKDVCDLYNTDM 196
            :..|..|:|.|...:||:||.::|:.|..|..||        |.:||:|..|::|||...|:.|:
Mouse   127 KRYRALLSPTFTSGRLKEMFPVIEQYGDILVKYL--------RQEAEKGMPVAMKDVLGAYSMDV 183

  Fly   197 IASIAFGLRSYSLRNTQSEIGSHCQ-----DLFRPNVRRIIDLFVIFYLPKLVP---LLRPKLFT 253
            |.|.:||:...||.|.:.......:     |.|.|.      ||.:...|.|.|   :|...:|.
Mouse   184 ITSTSFGVNVDSLNNPEDPFVEEAKKFLRVDFFDPL------LFSVVLFPLLTPVYEMLNICMFP 242

  Fly   254 EPHAEFLRRVIQLVIEER-ERGGDLRNDLIEMLLTLKKEADLQQDK-SHFTHHRDFLAAQAASFE 316
            ....||.::.:..:.|.| :.....|.|.:::::.....:   :|| ||.......:..|:..|.
Mouse   243 NDSIEFFKKFVDRMQESRLDSNQKHRVDFLQLMMNSHNNS---KDKDSHKAFSNMEITVQSIIFI 304

  Fly   317 VAGIETCSASMSFALYELAKQPLMQSRLRREIREAFASNPN-GRLTYEAVARMEFLDMVVEETLR 380
            .||.||.|:::||.||.||..|.:|.:|:.||.:|.   || ...|.:.|..||:||||:.||||
Mouse   305 SAGYETTSSTLSFTLYCLATHPDIQKKLQAEIDKAL---PNKATPTCDTVMEMEYLDMVLNETLR 366

  Fly   381 KYPIVPLLERECTPINKKRFYSLRPHAECYTRRGMPVFISNLAIHHDPKYWPDPDRFDPERFSAA 445
            .||||..|||.|     |:...|.   ..|..:|..|.|.:.|:||||::||||:.|.|||||..
Mouse   367 LYPIVTRLERVC-----KKDVELN---GVYIPKGSMVMIPSYALHHDPQHWPDPEEFQPERFSKE 423

  Fly   446 NKALQAPMSYMPFGAGPRNCIGMQIGLLQIKLGLVYFLHQHRVEICDRTVERIQFDAKFA---LL 507
            ||....|..|:|||.||||||||:..|:.:||.:...|.....:.|..|    |...|.:   :|
Mouse   424 NKGSIDPYVYLPFGIGPRNCIGMRFALMNMKLAVTKVLQNFSFQPCQET----QIPLKLSRQGIL 484

  Fly   508 ASEQRIYLKV 517
            ..|:.|.|||
Mouse   485 QPEKPIVLKV 494

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6v1	NP_001285499.1	p450	59..517	CDD:299894	158/474 (33%)
Cyp3a44	NP_796354.1	p450	39..494	CDD:278495	161/498 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.820