DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6v1 and Cyp309a1

DIOPT Version :9

Sequence 1:	NP_001285499.1	Gene:	Cyp6v1 / 33056	FlyBaseID:	FBgn0031126	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	NP_001259943.1	Gene:	Cyp309a1 / 33438	FlyBaseID:	FBgn0031432	Length:	506	Species:	Drosophila melanogaster

Alignment Length:	511	Identity:	134/511 - (26%)
Similarity:	227/511 - (44%)	Gaps:	69/511 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 ILLAIVTILTGV----FIWSRRTYVYWQRRRVKFVQPTHLLGNLSRVL-RLEESFALQLRRFY-- 64
            :.|.||.:...|    ..|..:   ||.:|.|...:|..:||:...:| ....|..|.::..|
  Fly     7 LCLTIVHVAFAVVYFYLTWYHK---YWDKRGVVTAEPLTILGSYPGILINKSRSLILDVQDVYNK 68

  Fly    65 FDERFRNEPVVGIYLFHQPALLIRDLQLVRTVLVEDFVSFSNRFAKC---DGRSDKMGALSLFLA 126
            :.:::|   .||.::..||.||:.|..|...:||:.|..|.:.....   ....||..|.|.|.:
  Fly    69 YKDKYR---TVGTFITRQPQLLVLDPALAHEILVDKFSHFRDTITSSFVGHNPDDKYVAGSPFFS 130

  Fly   127 KQPEWREIRTRLAPAFAGAKLKQMFSLMEEIGCDLEWYLKRLTRDLRRGDAERGAIVSIKDVCDL 191
            ...:|:.:|:........::||..:|:.|:.|..|..|::|..|       |:|.|:..:|:...
  Fly   131 AGDKWKRLRSENVGGLTPSRLKMAYSIWEQSGRKLVEYIERARR-------EQGDIIETRDLAYR 188

  Fly   192 YNTDMIASIAFGLRSYSLRNTQSEIG----------SHC-QDLFRPNVRRIIDLFVIFYLPKLVP 245
            :..:.:|...:|:.:.||.....|||          :|. ..:.|.| :.::.:||    .||..
  Fly   189 FTANAMADFIWGIDAGSLSGKVGEIGDFQKTSTDWSAHAFSSMIRFN-KTLVAIFV----RKLFS 248

  Fly   246 LLRPKLFTEPHAEFLRRVIQLVIEERERG-GDLRNDLIEMLLTLKKEADLQQDKSHFTHHRDFLA 309
            :   :.||:...||..|:.|..:..|:.| |:.|.|.:..|:.|::..:...|.          .
  Fly   249 M---RFFTKATDEFFLRLTQDAVNLRQGGSGEGRTDYLSHLIQLQQRGNSIHDS----------V 300

  Fly   310 AQAASFEVAGIETCSASMSFALYELAKQPLMQSRLRREIREAFASNPNGRLTYEAVARMEFLDMV 374
            ..|.:..:.|.||..|.:...||.|::....|.:||.||.||.||  .|:::|:.:..:.:||..
  Fly   301 GHALTVHLDGFETSGAVLYHMLYSLSEHHEEQEKLRSEILEALAS--EGQISYDQINNLPYLDQC 363

  Fly   375 VEETLRKYPIVPLLERECTP-----INKKRFYSLRPHAECYTRRGMPVFISNLAIHHDPKYWPDP 434
            ..|:||....:....|.||.     :...:...|.|        |:.|.:.....|||...:|:.
  Fly   364 FNESLRLTTPIGFFMRICTKPTQINLGDDKTLDLEP--------GVTVMVPAYQYHHDNDIYPEA 420

  Fly   435 DRFDPERF-SAANKALQAPMSYMPFGAGPRNCIGMQIGLLQIKLGLVYFLHQHRVE 489
            ..|.|:|| :.|...|.....::|||.|||.|:||::|.|.:|..:|:.|..::||
  Fly   421 SEFRPDRFENGAASVLTKRGCFLPFGDGPRICLGMRVGQLSVKTAIVHILSNYQVE 476

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6v1	NP_001285499.1	p450	59..517	CDD:299894	119/454 (26%)
Cyp309a1	NP_001259943.1	p450	49..481	CDD:299894	122/466 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45460841
Domainoid	1	1.000	88	1.000	Domainoid score	I2119
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	88	1.000	Inparanoid score	I1773
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	6.000