DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6v1 and cyp3c1

DIOPT Version :9

Sequence 1:	NP_001285499.1	Gene:	Cyp6v1 / 33056	FlyBaseID:	FBgn0031126	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	NP_997838.1	Gene:	cyp3c1 / 324340	ZFINID:	ZDB-GENE-030131-3060	Length:	505	Species:	Danio rerio

Alignment Length:	523	Identity:	140/523 - (26%)
Similarity:	251/523 - (47%)	Gaps:	74/523 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 ILLAIVTILTGVFIWSRRTYVYWQRRRVKFVQPTHLLGNLSRVLRLEESFALQLRRFYFDERFRN 71
            :::.::|:|....:|   .:.::::..:...:|...:|...       |::..:..|..:...:.
Zfish    13 LVVLVITLLLIYGVW---PHGFFKKLGIPGPRPLPFVGTAL-------SYSKGICNFDIECSKKY 67

  Fly    72 EPVVGIYLFHQPALLIRDLQLVRTVLVED-FVSFSNRFAKCDGRSDKMG--ALSLFLAKQPEWRE 133
            ..|.|||....|.||:.||::::|:||:| :.:|:||   .:...|.:|  |..:.|.|...||.
Zfish    68 GKVWGIYDGRLPLLLVTDLEMIKTILVKDCYSTFTNR---RNMNPDLVGPFADGITLVKDERWRR 129

  Fly   134 IRTRLAPAFAGAKLKQMFSLMEEIGCDLEWYLKRLTRDLRRGDAERGAIVSIKDVCDLYNTDMIA 198
            ||:.|:|.|...:||::|.:...       :..|..:::.:.|.  ...:.||||...|:.|::|
Zfish   130 IRSSLSPYFTSGRLKEIFPIAMT-------HADRFIKNMEKKDP--NLPLKIKDVVAPYSLDVVA 185

  Fly   199 SIAFGLRSYSLRNTQSEIGSHCQDLFRPNVRRIIDLFVIF-YLPKLVPLLRP---KLFTEPHAEF 259
            |.:|.:...|:.|......:..:..|  |:..:..||::. :.|....||..   .:|:....:|
Zfish   186 SSSFSVDFDSINNPDDPFVTSIKSFF--NINPLSPLFLLLAFCPSAANLLAKMGISVFSRSTTDF 248

  Fly   260 LRRVIQLVIEE-RERGGDLRNDLIEMLLTLK------KEADLQQDKSHFTHHRDFLAAQAASFEV 317
            ..:.::.:.:| .|..|  |.|.:::::..:      |:...:|.....|.|.  :.:|:..|.:
Zfish   249 YYKALRKIKDEHNESNG--RVDFLKLMIQNQIPDDQVKDTASEQPVKGLTDHE--ILSQSFIFIL 309

  Fly   318 AGIETCSASMSFALYELAKQPLMQSRLRREIREAFASN-PNGRLTYEAVARMEFLDMVVEETLRK 381
            .|.||.|.::|:.||.||..|....:|..||.:.|..: |   :||:|:.||::|:|.:.|::|.
Zfish   310 GGYETTSTTLSYLLYNLATNPDCLEKLVEEIDKNFPLDIP---ITYDALMRMDYLEMAIHESMRV 371

  Fly   382 YPIVPLLEREC----------TPINKKRFYSLRPHAECYTRRGMPVFISNLAIHHDPKYWPDPDR 436
            :|..|.|||.|          .|.|              |..|:|:::    :..||..|..|:.
Zfish   372 FPAGPRLERVCKKTVEINGITIPKN--------------TLVGIPLYV----LSRDPDLWESPNE 418

  Fly   437 FDPERFSAANKALQAPMSYMPFGAGPRNCIGMQIGLLQIKLGLVYFLHQHRVEICDRTVERIQFD 501
            |.|||||..:|......::||||.||||||||:..|:.:||.:|..|.::.||.|..|...:|.:
Zfish   419 FKPERFSPESKTEINQCAFMPFGLGPRNCIGMRFALMMMKLLVVKLLQKYTVETCKETQIPVQLN 483

  Fly   502 AKF 504
            ..|
Zfish   484 FFF 486

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6v1	NP_001285499.1	p450	59..517	CDD:299894	134/471 (28%)
cyp3c1	NP_997838.1	p450	38..496	CDD:278495	137/495 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		mtm8426
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.820