DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6v1 and Cyp28c1

DIOPT Version :9

Sequence 1:	NP_001285499.1	Gene:	Cyp6v1 / 33056	FlyBaseID:	FBgn0031126	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	NP_001259464.1	Gene:	Cyp28c1 / 32138	FlyBaseID:	FBgn0030339	Length:	505	Species:	Drosophila melanogaster

Alignment Length:	507	Identity:	135/507 - (26%)
Similarity:	226/507 - (44%)	Gaps:	41/507 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 NILLAIVTILTGVFIWSRRTYVYWQRRRVKFVQPTHLLGNLSRVLRLEESFALQLRRFYFDERFR 70
            ::||.|.|:|..::.:....:.:|:||.|...:...|.|:...::...:.|.:.:|..|.  .:|
  Fly     4 SLLLGIATLLGAIYAFLVSNFGHWRRRGVTEPRALPLFGSFPNMIWPRQHFTMDMRDIYM--HYR 66

  Fly    71 N-EPVVGIYLFHQPALLIRDLQLVRTVLVEDFVSFSNRFAK--CDGRSDKMGALSLFLAKQPEWR 132
            | ...||.||...|.||:.:.:||..:.|..|..|.|..|.  .|...|::.||:.|:.:..|||
  Fly    67 NTHSYVGCYLLRAPKLLVLEPRLVYEIYVSAFSHFENNDASKMVDIAKDRLVALNPFVLEGEEWR 131

  Fly   133 EIRTRLAPAFAGAKLKQMFSLMEEIGCDLEWYLKRLTRDLRRGDAERGAIVSIKDVCDL---YNT 194
            ..|...:......:::...::|:.:..||..::           |.:.|.....|..||   :..
  Fly   132 HQRAVFSTLLTNGRIRTTHAIMQRVCLDLCQFI-----------AIKSAGGKDLDCIDLGLRFTG 185

  Fly   195 DMIASIAFGLRSYSLRNTQSEIGSHCQDLFRPNVRRIIDLFVIFYLPKLVPLLRPKLFTEPHAEF 259
            :.:.....|:::.:..:....:.....::...|....|...|....|.|...||||:|...|..|
  Fly   186 ESLFDCVLGIQARTFTDNPLPVVRQNHEMSAENRGLAIAGAVHGLFPNLPRWLRPKVFPRSHDRF 250

  Fly   260 LRRVIQLVIEERERGGDLRNDLIEMLLTLKKEADLQQDKSHFTHHRDFLAAQAASFEVAGIETCS 324
            ..::|...:..|......|||.|..||.:::|.||.::.         :|:.|.:|...|::|.|
  Fly   251 YGQMISEALRLRRSKHQERNDFINHLLEMQRELDLSEED---------MASHAMTFMFDGLDTTS 306

  Fly   325 ASMSFALYELAKQPLMQSRLRREIREAFASNPNGRL-TYEAVARMEFLDMVVEETLRKYPIVPLL 388
            .|::..|..|.:.|..|.||..|::   ..||.|.| ..:|:..:.:|.....|:||.||.....
  Fly   307 NSIAHCLLLLGRNPDCQRRLYEELQ---LVNPGGYLPDLDALIDLPYLSACFNESLRIYPAGGWA 368

  Fly   389 ERECTPINKKRFYSLR--PHAE-CYTRRGMPVFISNLAIHHDPKYWPDPDRFDPERF-SAANKAL 449
            .:.||     :.|.||  .|:| ...|.|..|.:...|:|:||..:|:||.|.|||| ....|..
  Fly   369 SKTCT-----KEYELRGSHHSEPLKLRPGDHVMVPIYALHNDPDLYPEPDVFRPERFLDGGLKNC 428

  Fly   450 QAPMSYMPFGAGPRNCIGMQIGLLQIKLGLVYFLHQHRVEICDRTVERIQFD 501
            :....::.||.|||.|:||::||...|..|...:.:..|.:..||:...:.|
  Fly   429 KQQGIFLGFGNGPRQCVGMRLGLAMAKAALAAIVQRFEVVVSPRTLNGTELD 480

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6v1	NP_001285499.1	p450	59..517	CDD:299894	123/454 (27%)
Cyp28c1	NP_001259464.1	p450	35..487	CDD:299894	126/476 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45460811
Domainoid	1	1.000	88	1.000	Domainoid score	I2119
eggNOG	1	0.900	-	-		E2759_KOG0158
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	88	1.000	Inparanoid score	I1773
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	7	6.900