DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Cyp6v1 and Cyp3a2

DIOPT Version :9

Sequence 1:	NP_001285499.1	Gene:	Cyp6v1 / 33056	FlyBaseID:	FBgn0031126	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	NP_695224.3	Gene:	Cyp3a2 / 266682	RGDID:	708379	Length:	504	Species:	Rattus norvegicus

Alignment Length:	537	Identity:	167/537 - (31%)
Similarity:	261/537 - (48%)	Gaps:	69/537 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MVYSTNILLAIVTILT--------GVFIWSRRTYVYWQRRRVKFVQPTHLLGNLSRVLRLEESFA 57
            :...|.:|||::.:|.        |:|          :::.:...:|...||.:.       ::.
  Rat     7 LTLETWVLLAVILVLLYRLGTHRHGIF----------KKQGIPGPKPLPFLGTVL-------NYY 54

  Fly    58 LQLRRFYFDERFRNEPVVGIYLFHQPALLIRDLQLVRTVLVED-FVSFSNRFAKCDGRSDKMGAL 121
            ..|.||..:...:...:.|::....|...|.|.::::.|||:: |..|:||  :..|....||.
  Rat    55 KGLGRFDMECYKKYGKIWGLFDGQTPVFAIMDTEMIKNVLVKECFSVFTNR--RDFGPVGIMGK- 116

  Fly   122 SLFLAKQPEWREIRTRLAPAFAGAKLKQMFSLMEEIGCDLEWYLKRLTRDLRRGDAERGAIVSIK 186
            ::.:||..||:..|..|:|.|...:||:||.::|:.|..|..|||:        :||.|..|::|
  Rat   117 AVSVAKDEEWKRYRALLSPTFTSGRLKEMFPIIEQYGDILVKYLKQ--------EAETGKPVTMK 173

  Fly   187 DVCDLYNTDMIASIAFGLRSYSLRNTQSEIGSHCQDLFRPNVRRIIDLF-------VIF-YLPKL 243
            .|...|:.|:|.|.:||:...||.|.:.......:.|.|      .|.|       |:| :|..:
  Rat   174 KVFGAYSMDVITSTSFGVNVDSLNNPKDPFVEKTKKLLR------FDFFDPLFLSVVLFPFLTPI 232

  Fly   244 VPLLRPKLFTEPHAEFLRRVIQLVIEER-ERGGDLRNDLIEMLLTLKKEADLQQDKSHFTHHRDF 307
            ..:|...:|.:....|.::.:..:.|.| :.....|.|.::::|.....:  :.:.||.......
  Rat   233 YEMLNICMFPKDSIAFFQKFVHRIKETRLDSKHKHRVDFLQLMLNAHNNS--KDEVSHKALSDVE 295

  Fly   308 LAAQAASFEVAGIETCSASMSFALYELAKQPLMQSRLRREIREAFASN--PNGRLTYEAVARMEF 370
            :.||:..|..||.||.|:::||.||.||..|.:|.:|:.||..|..|.  |    ||:.|..||:
  Rat   296 IIAQSVIFIFAGYETTSSTLSFVLYFLATHPDIQKKLQEEIDGALPSKAPP----TYDIVMEMEY 356

  Fly   371 LDMVVEETLRKYPIVPLLERECTPINKKRFYSLRPHAECYTRRGMPVFISNLAIHHDPKYWPDPD 435
            ||||:.||||.|||...|||.|     |:...|   ...:..:|..|.|...|:||||::||.|:
  Rat   357 LDMVLNETLRLYPIGNRLERVC-----KKDIEL---DGLFIPKGSVVTIPTYALHHDPQHWPKPE 413

  Fly   436 RFDPERFSAANKALQAPMSYMPFGAGPRNCIGMQIGLLQIKLGLVYFLHQHRVEICDRTVERIQF 500
            .|.|||||..||....|..|:|||.||||||||:..|:.:||.|...|.....:.|..|...::.
  Rat   414 EFHPERFSKENKGSIDPYVYLPFGNGPRNCIGMRFALMNMKLALTKVLQNFSFQPCKETQIPLKL 478

  Fly   501 DAKFALLASEQRIYLKV 517
             ::.|:|..|:.|.|||
  Rat   479 -SRQAILEPEKPIVLKV 494

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6v1	NP_001285499.1	p450	59..517	CDD:299894	155/469 (33%)
Cyp3a2	NP_695224.3	CYP3A	67..493	CDD:410743	151/457 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.920