DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6v1 and Cyp3a23-3a1

DIOPT Version :9

Sequence 1:	NP_001285499.1	Gene:	Cyp6v1 / 33056	FlyBaseID:	FBgn0031126	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	NP_037237.2	Gene:	Cyp3a23-3a1 / 25642	RGDID:	628626	Length:	502	Species:	Rattus norvegicus

Alignment Length:	535	Identity:	165/535 - (30%)
Similarity:	261/535 - (48%)	Gaps:	67/535 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MVYSTNILLAIVTILTGVFIWSRRTYVYWQRRRVKFVQPTHLLGNLSRVLRLEESFALQLRRFYF 65
            :...|.:|||:|.:|  ::.:..||:..::::.:...:|....|.:.       ::.:.|.:|..
  Rat     7 LTLETWVLLAVVLVL--LYGFGTRTHGLFKKQGIPGPKPLPFFGTVL-------NYYMGLWKFDV 62

  Fly    66 DERFRNEPVVGIYLFHQPALLIRDLQLVRTVLVED-FVSFSNRFAKCDGRSDKMGALSLFLAKQP 129
            :...:...:.|::....|...|.|.::::.|||:: |..|:||  :..|....||. ::.::|..
  Rat    63 ECHKKYGKIWGLFDGQMPLFAITDTEMIKNVLVKECFSVFTNR--RDFGPVGIMGK-AISVSKDE 124

  Fly   130 EWREIRTRLAPAFAGAKLKQMFSLMEEIGCDLEWYLKRLTRDLRRGDAERGAIVSIKDVCDLYNT 194
            ||:..|..|:|.|...:||:||.::|:.|..|..||::          |:|..|.:|:|...|:.
  Rat   125 EWKRYRALLSPTFTSGRLKEMFPVIEQYGDILVKYLRQ----------EKGKPVPVKEVFGAYSM 179

  Fly   195 DMIASIAFGLRSYSLRNTQSEIGSHCQDLFRPNVRRIIDLF-VIFYLPKLVPLLRPK-------L 251
            |:|.|.:||:...||.|.:.......:.|.|      ||.| .:|....|.|.|.|.       :
  Rat   180 DVITSTSFGVNVDSLNNPKDPFVEKAKKLLR------IDFFDPLFLSVVLFPFLTPVYEMLNICM 238

  Fly   252 FTEPHAEFLRRVIQLVIEER-ERGGDLRNDLIEMLLTLKKEADLQQDKSHFTHHRDF-LAAQAAS 314
            |.:...||.::.:..:.|.| :.....|.|.:::::....::   :||...|...|. :.||:..
  Rat   239 FPKDSIEFFKKFVYRMKETRLDSVQKHRVDFLQLMMNAHNDS---KDKESHTALSDMEITAQSII 300

  Fly   315 FEVAGIETCSASMSFALYELAKQPLMQSRLRREIREAFASNPN-GRLTYEAVARMEFLDMVVEET 378
            |..||.|..|:::||.|:.||..|..|.:|:.||..|.   || ...||:.|..||:||||:.||
  Rat   301 FIFAGYEPTSSTLSFVLHSLATHPDTQKKLQEEIDRAL---PNKAPPTYDTVMEMEYLDMVLNET 362

  Fly   379 LRKYPIVPLLEREC---TPINKKRFYSLRPHAECYTRRGMPVFISNLAIHHDPKYWPDPDRFDPE 440
            ||.|||...|||.|   ..||           ..:..:|..|.|.:.|:|.||::||:|:.|.||
  Rat   363 LRLYPIGNRLERVCKKDVEIN-----------GVFMPKGSVVMIPSYALHRDPQHWPEPEEFRPE 416

  Fly   441 RFSAANKALQAPMSYMPFGAGPRNCIGMQIGLLQIKLGLVYFLHQHRVEICDRTVERIQFDAKFA 505
            |||..||....|..|:|||.||||||||:..|:.:||.|...|.....:.|..|    |...|.:
  Rat   417 RFSKENKGSIDPYVYLPFGNGPRNCIGMRFALMNMKLALTKVLQNFSFQPCKET----QIPLKLS 477

  Fly   506 ---LLASEQRIYLKV 517
               ||...:.|.|||
  Rat   478 RQGLLQPTKPIILKV 492

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6v1	NP_001285499.1	p450	59..517	CDD:299894	153/475 (32%)
Cyp3a23-3a1	NP_037237.2	p450	39..492	CDD:278495	155/499 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.920