Protein Alignment Cyp6v1 and Cyp3a18

DIOPT Version :10

• Sequence 1: NP_608403.1
• Gene: Cyp6v1 / 33056
• FlyBaseID: FBgn0031126
• Length: 520
• Species: Drosophila melanogaster
• Sequence 2: NP_665725.2
• Gene: Cyp3a18 / 252931
• RGDID: 628709
• Length: 497
• Species: Rattus norvegicus
• Alignment Length: 524
• Identity: 158/524 - (30%)
• Similarity: 266/524 - (50%)
• Gaps: 65/524 - (12%)

  Fly     5 TNILLAIVTILTGVFIWSRRTYVYWQRRRVKFVQPTHLLGNLSRVLRLEESFALQLRRFYFDERF 69
            |.:|||  |.|...:|:...::..:::..:...:|..|.|.:.       ::...:.:|..|...
  Rat    11 TWVLLA--TSLMLFYIYGTYSHGLFKKLGIPGPKPVPLFGTIF-------NYGDGMWKFDDDCYK 66

  Fly    70 RNEPVVGIYLFHQPALLIRDLQLVRTVLVEDFVS-FSNRFAKCDGRSDKMGAL--SLFLAKQPEW 131
            :...:.|.|...||.|.|.|.::::.|||::..| |:||  :|.|   .||.:  ::.:::..||
  Rat    67 KYGKIWGFYEGPQPFLAIMDPEIIKMVLVKECYSVFTNR--RCFG---PMGFMKKAITMSEDEEW 126

  Fly   132 REIRTRLAPAFAGAKLKQMFSLMEEIGCDLEWYLKRLTRDLRRGDAERGAIVSIKDVCDLYNTDM 196
            :.:||.|:|.|...|||:||.||.:.|       ..|.::|||.:| :|..:::||:...|:.|:
  Rat   127 KRLRTILSPTFTSGKLKEMFPLMRQYG-------DTLLKNLRREEA-KGEPINMKDIFGAYSMDV 183

  Fly   197 IASIAFGLRSYSLRNTQSEIGSHCQDLFRPNVRRIIDLF----VIF-YLPKLVPLLRPKLFTEPH 256
            |...:||:...||.|.|.......:.:.:   .:|.|.|    |:| :|..:..:|...:|....
  Rat   184 ITGTSFGVNVDSLNNPQDPFVQKAKKILK---FQIFDPFLLSVVLFPFLTPIYEMLNFSIFPRQS 245

  Fly   257 AEFLRRVIQLVIEER-ERGGDLRNDLIEMLLTLKKEADLQQDKSHFTHHRDF-LAAQAASFEVAG 319
            ..|.::.::.:.:.| :.....|.|.:::::..:.....:..|:    ..|. :||||..|...|
  Rat   246 MNFFKKFVKTMKKNRLDSNQKSRVDFLQLMMNTQNSKGQESQKA----LSDLEMAAQAIIFIFGG 306

  Fly   320 IETCSASMSFALYELAKQPLMQSRLRREIREAFASNPN-GRLTYEAVARMEFLDMVVEETLRKYP 383
            .:..|.|:||.:||||.:|.:|.:|:.||..|.   || ..:||:|:..||:|||||.|:||.||
  Rat   307 YDATSTSISFIMYELATRPNVQKKLQNEIDRAL---PNKAPVTYDALMEMEYLDMVVNESLRLYP 368

  Fly   384 IVPLLERECTPINKKRFYSLRPHAE---CYTRRGMPVFISNLAIHHDPKYWPDPDRFDPERFSAA 445
            |...|:|    ::||       ..|   .:..:|..|.|....:|.:|:||.:|:.|:|||||..
  Rat   369 IATRLDR----VSKK-------DVEINGVFIPKGTVVTIPIYPLHRNPEYWLEPEEFNPERFSKE 422

  Fly   446 NKALQAPMSYMPFGAGPRNCIGMQIGLLQIKLGLVYFLHQHRVEICDRTVERIQFDAKFALLASE 510
            ||....|..|:|||.||||||||:..|:.:||.::..|....::.|::|        :..|..|.
  Rat   423 NKGSIDPYVYLPFGNGPRNCIGMRFALISMKLAVIGVLQNFNIQPCEKT--------QIPLKISR 479

  Fly   511 QRIY 514
            |.|:
  Rat   480 QPIF 483

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6v1	NP_608403.1	CYP6-like	70..514	CDD:410679	145/457 (32%)
Cyp3a18	NP_665725.2	CYP3A	67..492	CDD:410743	146/459 (32%)