DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6v1 and Tbxas1

DIOPT Version :9

Sequence 1:	NP_001285499.1	Gene:	Cyp6v1 / 33056	FlyBaseID:	FBgn0031126	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	NP_035669.3	Gene:	Tbxas1 / 21391	MGIID:	98497	Length:	533	Species:	Mus musculus

Alignment Length:	555	Identity:	154/555 - (27%)
Similarity:	266/555 - (47%)	Gaps:	78/555 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 VYSTNILLAIVTILTGVFIW-SRRTYVYWQRRRVKFVQPTHLLGNLSRVLRLEESF---ALQLRR 62
            :.:..:|:|::.:|.    | |...:...::..::..:|:..:|||   :...:.|   .|:||.
Mouse    15 IVTVTLLVALLALLK----WYSMSAFSRLEKLGIRHPKPSPFVGNL---MFFRQGFWESQLELRE 72

  Fly    63 FYFDERFRNEPVVGIYLFHQPALLIRDLQLVRTVLVEDFVSFSNRFAKCDGRSDKMGALSLFLAK 127
            .|       .|:.|.||..:..::|.:..:::.||||:|.:||||.|  .|...||.|.|:.|.:
Mouse    73 RY-------GPLCGYYLGRRMHVVISEPDMIKQVLVENFSNFSNRMA--SGLEPKMVADSVLLLR 128

  Fly   128 QPEWREIRTRLAPAFAGAKLKQMFSLMEEIGCDLEWYLKRLTRDLRRGDAERGAIVSIKDVCDLY 192
            ...|.|:|..|..:|:..||.:|..|:.: .|:|      |...|:|..|.|.|....:..| .|
Mouse   129 DRRWEEVRGALMSSFSPEKLDEMTPLISQ-ACEL------LVAHLKRYAASRDAFNIQRCYC-CY 185

  Fly   193 NTDMIASIAFGLRSYSLRNTQSEIGSHCQDLFRPNVRRIIDLFVIFYLPKLVPLLR--PKLFTEP 255
            ..|::||:|||.:..|..:.:.....||:......:.|.:.:.::.:...:|||.|  |....:.
Mouse   186 TIDVVASVAFGTQVDSQNSPEDPFVQHCRRASTFCIPRPLLVLILSFPSIMVPLARILPNKNRDE 250

  Fly   256 HAEFLRRVIQLVI--EERERGGDLRNDLIEMLLTLK------------------KEADLQQDKSH 300
            ...|...:|:.||  .:::...:.|.|.::|:|..:                  ..::..::...
Mouse   251 LNGFFNTLIRNVIALRDQQAAEERRRDFLQMVLDAQHSMNSVGVEGFDMVPESLSSSECTKEPPQ 315

  Fly   301 FTHHR--------DFLAAQAASFEVAGIETCSASMSFALYELAKQPLMQSRLRREIREAFASNPN 357
            ..|..        |.:..||..|.:||.|..:.::||..|.||..|..|.||.:|:......:|.
Mouse   316 RCHPTSTSKPFTVDEIVGQAFLFLIAGHEVITNTLSFITYLLATHPDCQERLLKEVDLFMGKHPA 380

  Fly   358 GRLTYEAVAR-MEFLDMVVEETLRKYPIVPLLERE----CTPINKKRFYSLRPHAECYTRRGMPV 417
            ..  |.::.. :.:||||:.||||.||......||    |..:.::            ...|..:
Mouse   381 PE--YHSLQEGLPYLDMVISETLRMYPPAFRFTREAAQDCEVLGQR------------IPAGTVL 431

  Fly   418 FISNLAIHHDPKYWPDPDRFDPERFSAANKALQAPMSYMPFGAGPRNCIGMQIGLLQIKLGLVYF 482
            .|:..|:||||::||:|:.||||||:|..:..:.|.:|:|||||||:|:|:::|||.:||.::..
Mouse   432 EIAVGALHHDPEHWPNPETFDPERFTAEARLQRRPFTYLPFGAGPRSCLGVRLGLLVVKLTILQV 496

  Fly   483 LHQHRVEICDRTVERIQFDAKFALLASEQRIYLKV 517
            ||:.|.|....|...:|.::|.| |..:..:|:|:
Mouse   497 LHKFRFEASPETQVPLQLESKSA-LGPKNGVYIKI 530

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6v1	NP_001285499.1	p450	59..517	CDD:299894	142/492 (29%)
Tbxas1	NP_035669.3	p450	47..528	CDD:365848	147/515 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.820