DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6v1 and Cyp6a16

DIOPT Version :9

Sequence 1:	NP_001285499.1	Gene:	Cyp6v1 / 33056	FlyBaseID:	FBgn0031126	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	NP_001285631.1	Gene:	Cyp6a16 / 19836250	FlyBaseID:	FBgn0031726	Length:	500	Species:	Drosophila melanogaster

Alignment Length:	521	Identity:	174/521 - (33%)
Similarity:	276/521 - (52%)	Gaps:	42/521 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LLAIVTILTGVFIWSRRTYVYWQRRRVKFVQPTHLLGNLSRVLRLEESFALQLRRFYFDERFR-N 71
            ||.:.::|:.:..:.|..:.||:.|.:..::|..|.|:..|:..:..|..||  ..|  :.|| :
  Fly     5 LLLLTSLLSFLLGYLRYRFTYWELRGIPQLRPHFLFGHFFRLQSVHYSELLQ--ETY--DAFRGS 65

  Fly    72 EPVVGIYLFHQPALLIRDLQLVRTVLVEDFVSFSNRFAKCDGRS---DKMGALSLFLAKQPEWRE 133
            ..|.|.|:|.:|..::.||.||:.||:.||.:|.:|      ||   |.:.| :||..:..|||.
  Fly    66 AKVAGTYVFLRPMAVVLDLDLVKAVLIRDFNNFVDR------RSFHGDPLTA-NLFNLQGEEWRN 123

  Fly   134 IRTRLAPAFAGAKLKQMFSLMEEIGCDLEWYLKRLTRDLRRGDAERGAIVSIKDVCDLYNTDMIA 198
            :||:|:|.|...|:|.||..:..:...|......|.       ..:||::.:.|:...|.||:|.
  Fly   124 LRTKLSPTFTSGKMKYMFGTVSTVAQQLGGTFDELV-------GSQGAVLELHDLMARYTTDVIG 181

  Fly   199 SIAFGLRSYSLRNTQSEIGSHCQDLFRPNVRRI-IDLFVIFYLPKLVPLLRPKLFTEPH-AEFLR 261
            |.|||....|||..|:|.....:.:||.:.|.| ..:|.:.||..|..|..|.....|. .:|..
  Fly   182 SCAFGTECSSLREPQAEFRQVGRRIFRNSNRSIRWRIFKMTYLSSLAKLGLPVRILHPDITKFFN 246

  Fly   262 RVIQLVIEERERGGDLRNDLIEMLLTLKKEADLQQDKSHFTHHRDFLAAQAASFEVAGIETCSAS 326
            |:::..:|.|||....|||.:::||.|::    |::....|..:  :||||..|.|||.||.|::
  Fly   247 RIVRETVELRERENIRRNDFMDLLLDLRR----QENGKGLTMEQ--MAAQAFVFFVAGFETSSSN 305

  Fly   327 MSFALYELAKQPLMQSRLRREIREAFASNPNGRLTYEAVARMEFLDMVVEETLRKYPIVPLLERE 391
            ||:||:||||...:|.:||.||.::...  :|:|||||:..|.:||..:.|||||||.:..|.|.
  Fly   306 MSYALFELAKNQDVQQKLRMEINDSIGK--HGKLTYEAMMEMPYLDQTITETLRKYPALSSLTRL 368

  Fly   392 CTPINKKRFYSLRPHAE----CYTRRGMPVFISNLAIHHDPKYWPDPDRFDPERFSAANKALQAP 452
            .:     ..|.: |..:    ....:|..|.|..||||:||:.:|:|..|.||||:......:.|
  Fly   369 AS-----EDYEI-PSPDGGDPVVLEKGTSVHIPVLAIHYDPEVYPEPHEFRPERFAPDACRERHP 427

  Fly   453 MSYMPFGAGPRNCIGMQIGLLQIKLGLVYFLHQHRVEICDRTVERIQFDAKFALLASEQRIYLKV 517
            .:::.||.|||||||::.|.:|:|:||:..|.:.|..:...:..:::...:..:|.....:.|:|
  Fly   428 TAFLGFGDGPRNCIGLRFGRMQVKVGLITLLRRFRFSLPPGSPTQLKVTKRNLILLPSDGVRLQV 492

  Fly   518 D 518
            |
  Fly   493 D 493

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6v1	NP_001285499.1	p450	59..517	CDD:299894	159/467 (34%)
Cyp6a16	NP_001285631.1	p450	32..492	CDD:278495	165/491 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	151	1.000	Domainoid score	I1386
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	161	1.000	Inparanoid score	I1621
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	1	1.000	-	-		mtm8426
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24292
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X40
	8	8.070