DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Cyp6v1 and Cyp3a62

DIOPT Version :9

Sequence 1:	NP_001285499.1	Gene:	Cyp6v1 / 33056	FlyBaseID:	FBgn0031126	Length:	520	Species:	Drosophila melanogaster
Sequence 2:	NP_001019403.1	Gene:	Cyp3a62 / 170509	RGDID:	1595919	Length:	497	Species:	Rattus norvegicus

Alignment Length:	512	Identity:	157/512 - (30%)
Similarity:	255/512 - (49%)	Gaps:	73/512 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 TNILLAIVTILTGVFIWSRRTYVYWQRRRVKFVQPTHLLGNLSRVLRLEESFALQLRRFYFDERF 69
            |.:|||  |||..::::...|:..:::..:...:|...:||   :|.....|      :.||...
  Rat    11 TWMLLA--TILVLLYLYGTSTHGNFKKLGISGPKPLPFVGN---ILAYRHGF------WEFDRHC 64

  Fly    70 RNE--PVVGIYLFHQPALLIRDLQLVRTVLVED-FVSFSNRFAKCDGRS-DKMGAL--SLFLAKQ 128
            ..:  .:.|.|...||.|.|.|..:::||||:: :.:|:||      || ...|.|  ::.|::.
  Rat    65 HKKYGDIWGFYEGRQPILAITDPDIIKTVLVKECYSTFTNR------RSFGPAGILKKAITLSED 123

  Fly   129 PEWREIRTRLAPAFAGAKLKQMFSLMEEIGCDLEWYLKRLTRDLRRGDAERGAIVSIKDVCDLYN 193
            .||:.:||.|:|.|...|||:||.::.:       |...|.::::. :||:|..:::||:...|:
  Rat   124 EEWKRLRTLLSPTFTSGKLKEMFPIINQ-------YADLLVKNVKH-EAEKGNPITMKDIFGAYS 180

  Fly   194 TDMIASIAFGLRSYSLRNTQSEIGSHCQDLFRPNVRRIIDLFVIFYLPKLVPLLRP-------KL 251
            .|:|...:||:...||.|.|:......:.|.:.|   .:|.|.:..:  |.|.|.|       .:
  Rat   181 MDVITGTSFGVNVDSLNNPQNPFVQKVKKLLKFN---FLDPFFLSVI--LFPFLTPVFEAFDITV 240

  Fly   252 FTEPHAEFLRRVIQLVIEER-ERGGDLRNDLIEMLLTLKKEADLQQDKSHFTHHRDF----LAAQ 311
            |.:...:|.|..::.:.|.| :.....|.|.:::::..:...|.:.       |:..    :.||
  Rat   241 FPKDVMKFFRTSVERMKENRMQEKVKQRLDFLQLMINSQSSGDKES-------HQGLTDVEIVAQ 298

  Fly   312 AASFEVAGIETCSASMSFALYELAKQPLMQSRLRREIREAFASNPN-GRLTYEAVARMEFLDMVV 375
            :..|..||.||.|:::|||||.||..|.:|.:|:.||..|.   || ..:||:.:..||:||||:
  Rat   299 SIFFIFAGYETTSSALSFALYLLATHPDLQKKLQDEIDAAL---PNKAPVTYDVLVEMEYLDMVL 360

  Fly   376 EETLRKYPIVPLLEREC---TPINKKRFYSLRPHAECYTRRGMPVFISNLAIHHDPKYWPDPDRF 437
            .||||.:|:...|||.|   ..||           ..:..:|..|.:...|:|.|||.||:|:.|
  Rat   361 NETLRLFPVGGRLERVCKKDVEIN-----------GVFIPKGTVVMVPTFALHKDPKCWPEPEEF 414

  Fly   438 DPERFSAANKALQAPMSYMPFGAGPRNCIGMQIGLLQIKLGLVYFLHQHRVEICDRT 494
            .||||...|:....|..|:|||.||||||||:..|:.:|:.||..|......:|..|
  Rat   415 CPERFRKKNQDSINPYIYLPFGNGPRNCIGMRFALMNMKIALVRVLQNFSFGLCKET 471

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6v1	NP_001285499.1	p450	59..517	CDD:299894	144/458 (31%)
Cyp3a62	NP_001019403.1	p450	39..491	CDD:278495	149/482 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0158
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D264519at33208
OrthoFinder	1	1.000	-	-		FOG0000037
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X40
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.820