Protein Alignment Cyp6v1 and CYP3A5

DIOPT Version :10

• Sequence 1: NP_608403.1
• Gene: Cyp6v1 / 33056
• FlyBaseID: FBgn0031126
• Length: 520
• Species: Drosophila melanogaster
• Sequence 2: NP_000768.1
• Gene: CYP3A5 / 1577
• HGNCID: 2638
• Length: 502
• Species: Homo sapiens
• Alignment Length: 537
• Identity: 181/537 - (33%)
• Similarity: 276/537 - (51%)
• Gaps: 69/537 - (12%)

  Fly     1 MVYSTNILLAIVTILTGVFIWSRRTYVYWQRRRVKFVQPTHLLGNLSRVLRLEESFALQLRRFYF 65
            :...|.:|||:..:|  ::::..||:..::|..:....|..||||:.       |:...|.:|..
Human     7 LAVETWLLLAVSLVL--LYLYGTRTHGLFKRLGIPGPTPLPLLGNVL-------SYRQGLWKFDT 62

  Fly    66 DERFRNEPVVGIYLFHQPALLIRDLQLVRTVLVEDFVS-FSNRFAKCDGRSDKMGAL-----SLF 124
            :...:...:.|.|....|.|.|.|..::|||||::..| |:||      ||  :|.:     ::.
Human    63 ECYKKYGKMWGTYEGQLPVLAITDPDVIRTVLVKECYSVFTNR------RS--LGPVGFMKSAIS 119

  Fly   125 LAKQPEWREIRTRLAPAFAGAKLKQMFSLMEEIGCDLEWYLKRLTRDLRRGDAERGAIVSIKDVC 189
            ||:..||:.||:.|:|.|...|||:||.::.:.| |:      |.|:||| :||:|..|::||:.
Human   120 LAEDEEWKRIRSLLSPTFTSGKLKEMFPIIAQYG-DV------LVRNLRR-EAEKGKPVTLKDIF 176

  Fly   190 DLYNTDMIASIAFGLRSYSLRNTQSEIGSHCQDLFRPNVRRII------DLFV-IFYLPKLVPL- 246
            ..|:.|:|...:||:...||.|.        ||.|..:.::.:      .||: |...|.|.|:
Human   177 GAYSMDVITGTSFGVNIDSLNNP--------QDPFVESTKKFLKFGFLDPLFLSIILFPFLTPVF 233

  Fly   247 --LRPKLFTEPHAEFLRRVIQLVIEERERGGDLRNDLIEMLLTLKKEADLQQDKSHFTHHRDFLA 309
              |...||.:....||.:.:..:  ::.|..|.:...::.|..:....:.::.:||.......||
Human   234 EALNVSLFPKDTINFLSKSVNRM--KKSRLNDKQKHRLDFLQLMIDSQNSKETESHKALSDLELA 296

  Fly   310 AQAASFEVAGIETCSASMSFALYELAKQPLMQSRLRREIREAFASNPNGRLTYEAVARMEFLDMV 374
            ||:..|..||.||.|:.:||.|||||..|.:|.:|::|| :|...| ....||:||.:||:||||
Human   297 AQSIIFIFAGYETTSSVLSFTLYELATHPDVQQKLQKEI-DAVLPN-KAPPTYDAVVQMEYLDMV 359

  Fly   375 VEETLRKYPIVPLLEREC---TPINKKRFYSLRPHAECYTRRGMPVFISNLAIHHDPKYWPDPDR 436
            |.||||.:|:...|||.|   ..||           ..:..:|..|.|...|:|||||||.:|:.
Human   360 VNETLRLFPVAIRLERTCKKDVEIN-----------GVFIPKGSMVVIPTYALHHDPKYWTEPEE 413

  Fly   437 FDPERFSAANKALQAPMSYMPFGAGPRNCIGMQIGLLQIKLGLVYFLHQHRVEICDRTVERIQFD 501
            |.|||||....::. |..|.|||.||||||||:..|:.:||.|:..|.....:.|..|...::.|
Human   414 FRPERFSKKKDSID-PYIYTPFGTGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKETQIPLKLD 477

  Fly   502 AKFALLASEQRIYLKVD 518
            .: .||..|:.|.||||
Human   478 TQ-GLLQPEKPIVLKVD 493

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6v1	NP_608403.1	CYP6-like	70..514	CDD:410679	160/462 (35%)
CYP3A5	NP_000768.1	CYP3A	67..491	CDD:410743	161/464 (35%)