Protein Alignment Cyp6v1 and CYP3A4

DIOPT Version :10

• Sequence 1: NP_608403.1
• Gene: Cyp6v1 / 33056
• FlyBaseID: FBgn0031126
• Length: 520
• Species: Drosophila melanogaster
• Sequence 2: NP_059488.2
• Gene: CYP3A4 / 1576
• HGNCID: 2637
• Length: 503
• Species: Homo sapiens
• Alignment Length: 548
• Identity: 183/548 - (33%)
• Similarity: 275/548 - (50%)
• Gaps: 90/548 - (16%)

  Fly     1 MVYSTNILLAIVTILTGVFIWSRRTYVYWQRRRVKFVQPTHLLGNLSRVLRLEESFALQLRRFYF 65
            :...|.:|||:..:|  ::::...::..:::..:....|...|||   :|...:.|.:      |
Human     7 LAMETWLLLAVSLVL--LYLYGTHSHGLFKKLGIPGPTPLPFLGN---ILSYHKGFCM------F 60

  Fly    66 DERFRNE--PVVGIYLFHQPALLIRDLQLVRTVLVEDFVS-FSNR-------FAKCDGRSDKMGA 120
            |.....:  .|.|.|...||.|.|.|..:::||||::..| |:||       |.|        .|
Human    61 DMECHKKYGKVWGFYDGQQPVLAITDPDMIKTVLVKECYSVFTNRRPFGPVGFMK--------SA 117

  Fly   121 LSLFLAKQPEWREIRTRLAPAFAGAKLKQMFSLMEEIGCDLEWYLKRLTRDLRRGDAERGAIVSI 185
            :|  :|:..||:.:|:.|:|.|...|||:|..::.:.| |:      |.|:||| :||.|..|::
Human   118 IS--IAEDEEWKRLRSLLSPTFTSGKLKEMVPIIAQYG-DV------LVRNLRR-EAETGKPVTL 172

  Fly   186 KDVCDLYNTDMIASIAFGLRSYSLRNTQSEIGSHCQDLFRPNVRRII--DLFVIFYL-----PKL 243
            |||...|:.|:|.|.:||:...||.|.        ||.|..|.::::  |....|:|     |.|
Human   173 KDVFGAYSMDVITSTSFGVNIDSLNNP--------QDPFVENTKKLLRFDFLDPFFLSITVFPFL 229

  Fly   244 VPLLRPK---LFTEPHAEFLRRVIQLVIEER-ERGGDLRNDLIEMLLTLKKEADLQQDKSHFTHH 304
            :|:|...   :|......|||:.::.:.|.| |.....|.|.:::::      |.|..|...:|.
Human   230 IPILEVLNICVFPREVTNFLRKSVKRMKESRLEDTQKHRVDFLQLMI------DSQNSKETESHK 288

  Fly   305 --RDF-LAAQAASFEVAGIETCSASMSFALYELAKQPLMQSRLRREIREAFASNPNGRLTYEAVA 366
              .|. |.||:..|..||.||.|:.:||.:||||..|.:|.:|:.|| :|...| ....||:.|.
Human   289 ALSDLELVAQSIIFIFAGYETTSSVLSFIMYELATHPDVQQKLQEEI-DAVLPN-KAPPTYDTVL 351

  Fly   367 RMEFLDMVVEETLRKYPIVPLLEREC---TPINKKRFYSLRPHAECYTRRGMPVFISNLAIHHDP 428
            :||:|||||.||||.:||...|||.|   ..||           ..:..:|:.|.|.:.|:|.||
Human   352 QMEYLDMVVNETLRLFPIAMRLERVCKKDVEIN-----------GMFIPKGVVVMIPSYALHRDP 405

  Fly   429 KYWPDPDRFDPERFSAANKALQAPMSYMPFGAGPRNCIGMQIGLLQIKLGLVYFLHQHRVEICDR 493
            |||.:|::|.|||||..||....|..|.|||:||||||||:..|:.:||.|:..|.....:.|..
Human   406 KYWTEPEKFLPERFSKKNKDNIDPYIYTPFGSGPRNCIGMRFALMNMKLALIRVLQNFSFKPCKE 470

  Fly   494 TVERIQFDAKFA---LLASEQRIYLKVD 518
            |    |...|.:   ||..|:.:.|||:
Human   471 T----QIPLKLSLGGLLQPEKPVVLKVE 494

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cyp6v1	NP_608403.1	CYP6-like	70..514	CDD:410679	167/473 (35%)
CYP3A4	NP_059488.2	CYP3A	67..492	CDD:410743	167/473 (35%)