Protein Alignment RunxB and RUNX3

DIOPT Version :9

• Sequence 1: NP_001259745.1
• Gene: RunxB / 33051
• FlyBaseID: FBgn0259162
• Length: 663
• Species: Drosophila melanogaster
• Sequence 2: NP_001026850.1
• Gene: RUNX3 / 864
• HGNCID: 10473
• Length: 429
• Species: Homo sapiens
• Alignment Length: 400
• Identity: 150/400 - (37%)
• Similarity: 192/400 - (48%)
• Gaps: 72/400 - (18%)

  Fly   103 PENLIERTVDVLLAEHPGELVKTGSPHVVCTTLPTHWRSNKTLPIAFKVLALGEVMDGTIVTIRA 167
            ||  :...||| ||:|.||||:|.||:.:|:.||:|||.|||||:||||:|||:|.|||:||:.|
Human    64 PE--VRSMVDV-LADHAGELVRTDSPNFLCSVLPSHWRCNKTLPVAFKVVALGDVPDGTVVTVMA 125

  Fly   168 GNDENFCGELRNCTAVMKNQVAKFNDLRFVGRSGRGKSFTLTIVISTNPIQIATYTKAIKVTVDG 232
            |||||:..||||.:||||||||:||||||||||||||||||||.:.|||.|:|||.:||||||||
Human   126 GNDENYSAELRNASAVMKNQVARFNDLRFVGRSGRGKSFTLTITVFTNPTQVATYHRAIKVTVDG 190

  Fly   233 PREPRSKVRHQ-----GFHPFAFGPQRFGPDPLMAGLPFKLPGFAHHLVGMHSHLHAPDWRAHMA 292
            |||||   ||:     ...||   |.|||.               ...:.|......|..|..::
Human   191 PREPR---RHRQKLEDQTKPF---PDRFGD---------------LERLRMRVTPSTPSPRGSLS 234

  Fly   293 LGGRPAAFTAAPFFG-----------HHAAAFPTASGLRGLSGDSQQHQQQQQQHQLATVGAAHS 346
            .....::....|..|           ....:|||...|      ::......:.|....:.||.
Human   235 TTSHFSSQPQTPIQGTSELNPFSDPRQFDRSFPTLPTL------TESRFPDPRMHYPGAMSAAF- 292

  Fly   347 TTSPEGSPTTTTTSGTQLSAF--VQPPMTSS------PPPVTSLQHDNNNNNSNNNNSSSHIDAG 403
                   |.:.|.|||.:|:.  ...|.||.      |||..... .|.:.....|.|..|:..|
Human   293 -------PYSATPSGTSISSLSVAGMPATSRFHHTYLPPPYPGAP-QNQSGPFQANPSPYHLYYG 349

  Fly   404 FESDSISVTGSPRKSLGSPLTHDEEEAEAEAEAEAEAEAEAEEAEVGGLSRNGGGIQGPLHSESS 468
            ..|.|...:.....|.|...:.....|...:.|.:.|........:||.|   .|::......:|
Human   350 TSSGSYQFSMVAGSSSGGDRSPTRMLASCTSSAASVAAGNLMNPSLGGQS---DGVEADGSHSNS 411

  Fly   469 PGSGGAFTAL 478
            |      |||
Human   412 P------TAL 415

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RunxB	NP_001259745.1	Runt	118..239	CDD:279225	90/120 (75%)
RUNX3	NP_001026850.1	Runt	76..197	CDD:307137	90/123 (73%)
		Atrophin-1	<191..325	CDD:331285	35/168 (21%)
		RunxI	330..429	CDD:312115	20/95 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	212	1.000	Domainoid score	I2778
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	212	1.000	Inparanoid score	I3652
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000993
OrthoInspector	1	1.000	-	-		mtm8468
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11950
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X738
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	7.060